#Prevalence of #mcr1 in commensal #Escherichia coli from #French #livestock, 2007 to 2014 (@eurosurveillanc, abstract)

[Source: Eurosurveillance, full page: (LINK). Abstract, edited.]

Eurosurveillance, Volume 21, Issue 6, 11 February 2016  / Rapid communication

Prevalence of mcr-1 in commensal Escherichia coli from French livestock, 2007 to 2014 [      ]

A Perrin-Guyomard 1, M Bruneau 1, P Houée 1, K Deleurme 1, P Legrandois 1, C Poirier 1, C Soumet 1, P Sanders 1

Author affiliations: 1. ANSES, Laboratoire de Fougères, Fougères, France

Correspondence: Agnès Perrin-Guyomard ( agnes.perrin-guyomard@anses.fr)

Citation style for this article: Perrin-Guyomard A, Bruneau M, Houée P, Deleurme K, Legrandois P, Poirier C, Soumet C, Sanders P. Prevalence of mcr-1 in commensal Escherichia coli from French livestock, 2007 to 2014. Euro Surveill. 2016;21(6):pii=30135. DOI: http://dx.doi.org/10.2807/1560-7917.ES.2016.21.6.30135

Received:04 February 2016; Accepted:11 February 2016

 

Abstract

Colistin resistance was investigated in 1,696 isolates collected from 2007 to 2014 within the frame of the French livestock antimicrobial resistance surveillance programme. The mcr-1 gene was detected in all commensal Escherichia coli isolates with a minimum inhibitory concentration to colistin above the 2 mg/L cut-off value (n=23). In poultry, mcr-1 prevalence was 5.9% in turkeys and 1.8% in broilers in 2014. In pigs, investigated in 2013, this prevalence did not exceed 0.5%. These findings support that mcr-1 has spread in French livestock.

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Keywords: Research; Abstracts; Antibiotics; Drugs Resistance; E. Coli; Colistins.

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#Zika virus #infections in three #travellers returning from South #America and the #Caribbean respectively, to #France, Dec. ‘15–Jan. ‘16 (@eurosurveillanc, abstract)

[Source: Eurosurveillance, full page: (LINK). Abstract, edited.]

Rapid communication

Zika virus infections in three travellers returning from South America and the Caribbean respectively, to Montpellier, France, December 2015 to January 2016 [      ]

AT Maria 1,2, M Maquart 3, A Makinson 1,2, O Flusin 3, M Segondy 2,4,5, I Leparc-Goffart 3, V Le Moing 1,2, V Foulongne 2,4,5

Author affiliations: 1. Department of Infectious Diseases and Tropical Medicine, Montpellier University Hospital, Montpellier, France; 2. University of Montpellier, Montpellier, France; 3. Centre national de référence des Arbovirus, Institut de Recherche Biomédicale des Armées, Marseille, France; 4. Laboratory of Virology, Montpellier University Hospital, Montpellier, France; 5. INSERM U1058, Pathogenesis and Control of Chronic Infections, Montpellier, France

Correspondence: Vincent Foulongne ( v-foulongne@chu-montpellier.fr)

Citation style for this article: Maria A, Maquart M, Makinson A, Flusin O, Segondy M, Leparc-Goffart I, Le Moing V, Foulongne V. Zika virus infections in three travellers returning from South America and the Caribbean respectively, to Montpellier, France, December 2015 to January 2016. Euro Surveill. 2016;21(6):pii=30131. DOI: http://dx.doi.org/10.2807/1560-7917.ES.2016.21.6.30131

Received:28 January 2016; Accepted:10 February 2016

 

Abstract

We report three unrelated cases of Zika virus infection in patients returning from Martinique, Brazil and Colombia respectively, to Montpellier, France. They developed symptoms compatible with a mosquito-borne disease, and serological and molecular investigations indicated a recent Zika virus infection. Considering the recent warning for the likely teratogenicity of Zika virus and the presence of competent mosquito vectors in southern France, these cases highlight the need for awareness of physicians and laboratories in Europe. Since early 2015 there has been a rapid spread of Zika virus infections in South America with a subsequent threat for importation of that emerging disease in other regions of the world. Here we describe three cases in travellers returning to France from affected areas.

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Keywords: Research; Abstracts; Zika Virus; France.

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#Susceptibility of enterohaemorrhagic #Escherichia coli to #azithromycin in #France and analysis of resistance mechanisms (J Antimicrob Chemother., abstract)

[Source: Journal of Antimicrobial Chemotherapy, full page: (LINK). Abstract, edited.]

Susceptibility of enterohaemorrhagic Escherichia coli to azithromycin in France and analysis of resistance mechanisms [      ]

Christelle Jost 1,2,3, Philippe Bidet 1,2,3, Thibault Carrère 1, Patricia Mariani-Kurkdjian 1 and Stéphane Bonacorsi 1,2,3,*

Author Affiliations: ¹Service de Microbiologie, Centre National de Référence associé, AP-HP, Hôpital Robert Debré, Paris, France ²Univ Paris Diderot, Sorbonne Paris Cité, Paris, France ³INSERM, IAME, UMR 1137, F-75018 Paris, France

*Corresponding author. Service de Microbiologie, Hôpital Robert-Debré, 48 Boulevard Sérurier, 75019 Paris, France. Tel: +33140032340; Fax: +33140032450; E-mail: stephane.bonacorsi@aphp.fr

Received October 28, 2015. Revision requested November 27, 2015. Revision received December 11, 2015. Accepted December 14, 2015.

 

Abstract

Objectives

Antibiotic therapy is not recommended during enterohaemorrhagic Escherichia coli (EHEC) infection. However, the potential benefit of azithromycin has recently been described. This study was conducted to evaluate the macrolide susceptibility of EHEC isolates from France and to analyse the mechanisms of resistance to azithromycin in EHEC.

Methods

Strains from patients with EHEC infections were collected by the associated French National Reference Laboratory for E. coli from 2004 to 2014. Antimicrobial susceptibility testing was performed by disc diffusion and Etest methods. For strains presenting macrolide resistance, antibiotic resistance genes were searched for by PCR. Genetic transfer was performed by conjugation and plasmid analysis was done by Southern-blot hybridization after PFGE.

Results

We tested 508 isolates of EHEC. Azithromycin MICs ranged between 0.25 and 16 mg/L (median = 3 mg/L), except for two atypical strains, 34396 and 36493, for which MICs were >256 mg/L. Plasmid transferability of macrolide resistance was demonstrated. Strain 34396, of serotype O106:H18, harboured two macrolide resistance genes [mph(A) and erm(B)] and two other antimicrobial resistance genes (bla_DHA-1 for β-lactam resistance and qnrB4 for quinolone resistance). mph(A), bla_DHA-1 and qnrB4 were localized on the same plasmid. Strain 36493 belonging to the highly virulent O26:H11 EHEC clonal group harboured a plasmid containing mph(A).

Conclusions

For the first time we describe plasmid-borne macrolide resistance genes in EHEC strains. Dissemination of such plasmids may threaten the potential benefit of azithromycin during the management of patients infected or colonized with EHEC. Determination of azithromycin MICs should be considered prior to its therapeutic use and 16 mg/L may be used as the epidemiological cut-off value.

© The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

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Keywords: Research; Abstracts; Antibiotics; Drugs Resistance; France; E. Coli; Azithromycin.

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#France, Cas de #peste [#grippe] #aviaire au #zoo Val d’Hérault de St Thibéry près de #Béziers (France TV, Dec. 22 ‘15)

[Source: France TV, full page: (LINK).]

Cas de peste aviaire au zoo Val d’Hérault de St Thibéry près de Béziers [      ]

L.C. et S.B. / Publié le 22/12/2015 | 11:34, mis à jour le 22/12/2015 | 17:12

Des cas de peste aviaire ont été détectés au zoo de Val d’Hérault à Saint Thibéry . Les vétérinaires de la L.P.O. devaient euthanasier une quinzaine d’oiseaux du Sénégal pour éviter toute contamination. Finalement les oiseaux seront isolés puis transférés vers d’autres zoos.

(…)

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Keywords: Avian Influenza; Poultry; France.

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#France, #Grippe #aviaire: onze nouveaux cas dans le Sud-Ouest (Le Parisien, Dec. 21 ‘15)

[Source: Le Parisien, full page: (LINK).]

Grippe aviaire: onze nouveaux cas dans le Sud-Ouest [      ]

Onze nouveaux foyers de grippe aviaire ont été identifiés dans le sud-ouest en fin de semaine dernière, portant le total à 53 foyers, a annoncé le ministère de l’Agriculture lundi après-midi.Onze cas supplémentaires…

(…)

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Keywords: France; Avian Influenza; Poultry.

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#France, #Méningite C: #vaccination recommandée après des décès en Creuse, Allier et #Rhône (ARS) (Le Parisien, Dec. 18 ‘15)

[Source: Le Parisien, full page: (LINK).]

Méningite C: vaccination recommandée après des décès en Creuse, Allier et Rhône (ARS) [      ]

Quatre cas, dont trois mortels, de méningite C liés à une souche “très virulente” ont été recensés en Allier et en Creuse, a-t-on appris vendredi auprès des Agences régionales de santé (ARS)…

(…)

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Keywords: France; Meningitis.

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#Rhône. Un #collégien décède d’une #méningite foudroyante (Ouest #France, Dec. 18 ‘15)

[Source: Ouest France, full page: (LINK). Edited.]

Rhône. Un collégien décède d’une méningite foudroyante [      ]

by Ouest-France avec agences 

L’Agence régionale de santé (ARS) Rhône-Alpes a recommandé la vaccination contre la méningite pour l’ensemble de la population âgée de 12 mois à 24 ans dans plusieurs communes du Rhône.

(…)

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Keywords: France; Meningitis.

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#Dissemination of the #mcr1 #colistin #resistance #gene [#2] (The Lancet Infect Dis., extract)

[Source: The Lancet Infectious Diseases, full page: (LINK). Extract.]

Correspondence

Dissemination of the mcr-1 colistin resistance gene [      ]

Hattie E Webb, Sophie A Granier, Muriel Marault, Yves Millemann, Henk C den Bakker, Kendra K Nightingale, Marie Bugarel, Sarah A Ison, H Morgan Scott, Guy H Loneragan

Published Online: 17 December 2015 / Publication stage: In Press Corrected Proof / DOI: http://dx.doi.org/10.1016/S1473-3099(15)00538-1

© 2015 Elsevier Ltd. All rights reserved.

 

Summary

In response to the Yi-Yun Liu and colleagues’ finding of a mobile genetic element responsible for colistin resistance, mcr-1,¹ and the accompanying Comment asking “is plasmid-mediated colistin resistance a purely Chinese phenomenon?”², we, and others,^{3, 4} can now reply no. As part of routine surveillance, we screened 8684 salmonella isolates collected during 2012–13 from the French agricultural food sector for colistin resistance using disk diffusion.⁵ Between October and December, 2013, 27 isolates that showed a reduced susceptibility to colistin (ie, zone of inhibition <15 mm) were further assessed using a colistin concentration gradient assay. Five isolates (0·06%) had a distinctly different minimum inhibitory concentration (≥4 mg/mL) and were defined as colistin-resistant. In 2014, whole-genome sequencing of the five isolates was done and resultant sequences were assembled and interrogated for mutations and genetic elements associated with colistin resistance.

(…)

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Keywords: Research; Abstracts; Antibiotics; Drugs Resistance; Colistin; France; Enterobacteriaceae.

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#Tula #hantavirus #infection in a hospitalised patient, #France, June 2015 (@eurosurveillanc, abstract)

[Source: Eurosurveillance, full page: (LINK). Abstract, edited.]

Eurosurveillance, Volume 20, Issue 50, 17 December 2015  / Rapid communication

Tula hantavirus infection in a hospitalised patient, France, June 2015 [      ]

J Reynes ¹, D Carli ¹, N Boukezia ², M Debruyne ³, S Herti ⁴

Author affiliations: 1. Centre National de Référence des Hantavirus, Unité de Biologie des Infections Virales Emergentes, Institut Pasteur, Centre International de Recherche en Infectiologie, Lyon, France 2. Laboratoire, Centre Hospitalier de Coulommiers, Coulommiers, France 3. Laboratoire Cerba, Cergy Pontoise, France 4. Service de Médecine Interne, Centre Hospitalier de Coulommiers, Coulommiers France

Correspondence: Jean-Marc Reynes ( jean-marc.reynes@pasteur.fr)

Citation style for this article: Reynes J, Carli D, Boukezia N, Debruyne M, Herti S. Tula hantavirus infection in a hospitalised patient, France, June 2015. Euro Surveill. 2015;20(50):pii=30095. DOI: http://dx.doi.org/10.2807/1560-7917.ES.2015.20.50.30095

Received:30 November 2015; Accepted:17 December 2015

 

Abstract

We report an infection with Tula virus in June 2015, leading to hospitalisation, in a patient living approximately 60 km east of Paris with no previous remarkable medical history. Clinical symptoms were limited to a fever syndrome with severe headache. The main laboratory findings included thrombocytopenia and elevated transaminase levels. Based on S (small) gene sequence analysis, the strain affecting the patient was closely related to strains detected in Central Europe, especially to a south-east German strain.

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Keywords: Research; Abstracts; France; Hantavirus.

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#France, 15 nouveaux #foyers de #grippe #aviaire découverts dans le sud-ouest (Le Parisien, Dec. 16 ‘15)

[Source: Le Parisien, full page: (LINK).]

15 nouveaux foyers de grippe aviaire découverts dans le sud-ouest [      ]

Quinze nouveaux foyers de grippe aviaire ont été détectés depuis le début de la semaine dans quatre départements du sud-ouest de la France, portant le nombre total de cas confirmés à 30, a indiqué mercredi…

(…)

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Keywords: France; Avian Influenza; Poultry; H5N1; H5N2; H5N3; H5N9.

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