[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
Glob Health Action. 2019;12(1):1666566. doi: 10.1080/16549716.2019.1666566.
ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas.
Wilder-Smith A1, Preet R1, Brickley EB2, Ximenes RAA3,4, Miranda-Filho DB4, Turchi Martelli CM5, Araújo TVB6, Montarroyos UR7, Moreira ME8, Turchi MD9, Solomon T10, Jacobs BC11, Villamizar CP12,13, Osorio L13, de Filipps AMB14, Neyts J15, Kaptein S15, Huits R16, Ariën KK16, Willison HJ17, Edgar JM17, Barnett SC17, Peeling R2, Boeras D2, Guzman MG18, de Silva AM19, Falconar AK2,20, Romero-Vivas C20, Gaunt MW2, Sette A21,22, Weiskopf D21, Lambrechts L23, Dolk H24, Morris JK25, Orioli IM26, O’Reilly KM2, Yakob L2, Rocklöv J1, Soares C27, Ferreira MLB28, Franca RFO29, Precioso AR30,31, Logan J2, Lang T32, Jamieson N32, Massad E33,34.
Author information: 1 Department of Epidemiology and Global Health, Umeå University , Umeå , Sweden. 2 London School of Hygiene & Tropical Medicine , London , UK. 3 Departamento de Medicina Tropical, Universidade Federal de Pernambuco , Recife , Brasil. 4 Departamento de Medicina Interna, Universidade de Pernambuco , Recife , Brasil. 5 Instituto Aggeu Magalhães, Fundação Oswaldo Cruz , Recife , Brasil. 6 Departamento de Medicina Social, Universidade Federal de Pernambuco , Recife , Brasil. 7 Instituto de Ciências Biológicas, Universidade de Pernambuco , Recife , Brasil. 8 Instituto Fernandes Figueira – Fundação Oswaldo Cruz , Rio de Janeiro , Brasil. 9 Instituto de Patologia Tropical e Saúde Publica, Universidade Federal de Goiás , Goiânia , Brasil. 10 Institute of Infection and Global Health, The University of Liverpool , Liverpool , UK. 11 Departments of Neurology and Immunology, Erasmus Universitair Medisch Centrum Rotterdam , The Netherlands. 12 Johns Hopkins University , Baltimore , MD , USA. 13 Universidad del Valle , Colombia. 14 Laboratório de Flavivírus, Instituto Oswaldo Cruz , Brazil. 15 Department of Microbiology, Immunology and Transplantation, KU Leuven, Rega Institute of Medical Research , Leuven , Belgium. 16 Institute of Tropical Medicine , Antwerp , Belgium. 17 Institute of Infection, Immunity & Inflammation, University of Glasgow , Glasgow , UK. 18 Insitituto Medicina Tropical , Pedro Kouri , Cuba. 19 Department of Microbiology and Immunology, University of North Carolina at Chapel Hill , NC , USA. 20 Departmento del Medicina, Fundacion Universidad del Norte , Barranquilla , Colombia. 21 Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology , La Jolla , CA , USA. 22 Department of Medicine, University of California San Diego , La Jolla , CA , USA. 23 Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS , Paris , France. 24 Maternal Fetal and Infant Research Centre, Institute of Nursing and Health Research, Ulster University , Newtownabbey , UK. 25 Population Health Research Institute, St George’s, University of London , London , UK. 26 Associação Técnico-Científica Estudo Colaborativo Latino Americano de Malformações Congênitas (ECLAMC) no Departmento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil. 27 Hospital Federal dos Servidores do Estado , Rio de Janeiro , Brazil. 28 Hospital da Restauração , Recife , Brazil. 29 Oswaldo Cruz Foundation , Recife , Brazil. 30 Instituto Butantan , Brazil. 31 Pediatrics Department, Medical School of University of Sao Paulo , Sao Paulo , Brazil. 32 The Global Health Network, Masters and Scholars of the University of Oxford , Oxford , UK. 33 Fundacao de Apoio a Universidade de Sao Paulo , Sao Paulo , Brazil. 34 School of Applied Mathematics, Fundacao Getulio Vargas , Rio de Janeiro , Brazil.
Zika Preparedness Latin American Network (ZikaPLAN) is a research consortium funded by the European Commission to address the research gaps in combating Zika and to establish a sustainable network with research capacity building in the Americas. Here we present a report on ZikaPLAN`s mid-term achievements since its initiation in October 2016 to June 2019, illustrating the research objectives of the 15 work packages ranging from virology, diagnostics, entomology and vector control, modelling to clinical cohort studies in pregnant women and neonates, as well as studies on the neurological complications of Zika infections in adolescents and adults. For example, the Neuroviruses Emerging in the Americas Study (NEAS) has set up more than 10 clinical sites in Colombia. Through the Butantan Phase 3 dengue vaccine trial, we have access to samples of 17,000 subjects in 14 different geographic locations in Brazil. To address the lack of access to clinical samples for diagnostic evaluation, ZikaPLAN set up a network of quality sites with access to well-characterized clinical specimens and capacity for independent evaluations. The International Committee for Congenital Anomaly Surveillance Tools was formed with global representation from regional networks conducting birth defects surveillance. We have collated a comprehensive inventory of resources and tools for birth defects surveillance, and developed an App for low resource regions facilitating the coding and description of all major externally visible congenital anomalies including congenital Zika syndrome. Research Capacity Network (REDe) is a shared and open resource centre where researchers and health workers can access tools, resources and support, enabling better and more research in the region. Addressing the gap in research capacity in LMICs is pivotal in ensuring broad-based systems to be prepared for the next outbreak. Our shared and open research space through REDe will be used to maximize the transfer of research into practice by summarizing the research output and by hosting the tools, resources, guidance and recommendations generated by these studies. Leveraging on the research from this consortium, we are working towards a research preparedness network.
KEYWORDS: European Commission; Guillain-Barré syndrome; Zika; birth defect; congenital Zika syndrome; encephalitis; epidemic preparedness; microcephaly; research capacity building; sustainability
PMID: 31640505 DOI: 10.1080/16549716.2019.1666566
Keywords: Zika Virus; Pandemic Preparedness; American Region.