[Source: Journal of Medical Virology, full page: (LINK). Abstract, edited.]
High prevalence of SARS‐CoV‐2 and influenza A virus (H1N1) co‐infection in dead patients in Northeastern Iran
Seyed Ahmad Hashemi MD, Saghar Safamanesh MSc, Hamed Ghasem Zadeh‐moghaddam, Majid Ghafouri MD, Azimian Amir PhD
First published: 28 July 2020 | DOI: https://doi.org/10.1002/jmv.26364
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/jmv.26364
In the last months of 2019, an outbreak of fatal respiratory disease started in Wuhan, China, and quickly spread to other parts of the world. It named COVID‐19, and to date, thousands of cases of infection and death reported worldwide. The disease is associated with a wide range of symptoms that make it difficult to diagnose it accurately. The previous SARS pandemic in 2003, researchers found that the patients with fever, cough, or sore throat had a 5% influenza virus‐positive rate. This finding sparked in our minds that the wide range of symptoms and also relatively high prevalence of death in our patients may be due to the co‐infection with other viruses. Thus, we evaluate the co‐infection of SARS‐CoV‐2 with other respiratory viruses in dead patients in North Khorasan. We evaluated the presence of influenza A/B virus, Human metapneumovirus, bocavirus, adenovirus, respiratory syncytial virus, and parainfluenza viruses in 105 SARS‐CoV‐2 positive dead patients, using PCR and RT‐PCR tests. We found co‐infection with influenza virus in 22.3%, respiratory syncytial virus, and bocavirus in 9.7%, parainfluenza viruses in 3.9%, Human metapneumovirus in 2.9% and finally adenovirus in 1.9% of SARS‐CoV‐2 positive dead cases.
The highlights of our findings are a high prevalence of co‐infection with influenza A virus and the monopoly of co‐infection with Human metapneumovirus in children.
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Keywords: SARS-CoV-2; COVID-19; Seasonal Influenza; H1N1pdm09; Metapneumovirus; Iran.