[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
Influenza Other Respir Viruses. 2015 Sep;9(5):271-6. doi: 10.1111/irv.12324.
Nomenclature updates resulting from the evolution of avian influenza A(H5) virus clades 188.8.131.52a, 2.2.1, and 2.3.4 during 2013-2014. [ ][ ]
Author information: 1Program of Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore city, Singapore. 2Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA.
The A/goose/Guangdong/1/96-like hemagglutinin (HA) genes of highly pathogenic avian influenza (HPAI) A(H5) viruses have continued to rapidly evolve since the most recent update to the H5 clade nomenclature by the WHO/OIE/FAO H5N1 Evolution Working Group. New clades diverging beyond established boundaries need to be identified and designated accordingly.
Hemagglutinin sequences deposited in publicly accessible databases up to December 31, 2014, were analyzed by phylogenetic and average pairwise distance methods to identify new clades that merit nomenclature changes.
Three new clade designations were recommended based on division of clade 2·1·3·2a (Indonesia), 2·2·1 (Egypt), and 2·3·4 (widespread detection in Asia, Europe, and North America) that includes newly emergent HPAI virus subtypes H5N2, H5N3, H5N5, H5N6, and H5N8.
Continued global surveillance for HPAI A(H5) viruses in all host species and timely reporting of sequence data will be critical to quickly identify new clades and assess their potential impact on human and animal health.
© 2015 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
KEYWORDS: H5 subtype; clade nomenclature; hemagglutinin; highly pathogenic avian influenza; molecular epidemiology; phylogenetics; viral evolution
PMID: 25966311 [PubMed – indexed for MEDLINE]
PMCID: PMC4548997 Free PMC Article
Keywords: Research; Abstracts; Avian Influenza; H5N1; H5N2; H5N3; H5N8.