[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
Zhonghua Bing Li Xue Za Zhi, 40 (0), E006 2020 Mar 16 [Online ahead of print]
[Comparison of Pathological Changes and Pathogenic Mechanisms Caused by H1N1 Influenza Virus, Highly Pathogenic H5N1 Avian Influenza Virus, SARS-CoV, MERS-CoV and 2019-nCoV Coronavirus]
[Article in Chinese]
M Liu 1, R E Feng 2, Q Li 3, H K Zhang 1, Y G Wang 1
Affiliations: 1 Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China. 2 Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. 3 Shunyi Hospital of Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 101300, China.
PMID: 32174094 DOI: 10.3760/cma.j.cn112151-20200301-00155
The rapid development of the new coronavirus pneumonia epidemic in Wuhan, China, has caused severe impact on the country, but so far, little is known about the pathological changes and pathogenesis of the new coronavirus pneumonia. This article summarizes the pathological changes of severe influenza virus H1N1, highly pathogenic avian influenza virus H5N1, SARS-CoV, MERS-CoV, and 2019-nCoV coronavirus that cause major outbreaks of viral infectious diseases. The autopsy lung tissues are diffuse. Alveolar damage (DAD), but pathological manifestations caused by different viruses are different. Severe influenza virus 2009 H1N1 virus binds to receptors α-2,6-SA and α-2,3-SA, except for DAD lesions It is often accompanied by inflammatory lesions of the upper respiratory tract, trachea, bronchi and bronchioles, and is more likely to be complicated by bacterial infection. The highly pathogenic avian influenza virus H5N1 mainly binds α-2,3-SA receptors, mainly involving alveolar epithelium and bronchioles. Rarely, upper respiratory tract and trachea and bronchial lesions are often associated with focal pulmonary hemorrhage and lung tissue necrosis. Mechanization and fibrosis are rare. SARS-CoV enters cells by binding to angiotensin-converting enzyme 2 (ACE2), and the lesions are related to the course of disease. The DAD exudation period is generally seen in patients who die within 10 to 14 days. Patients with a disease course of more than 10 days showed mechanized DAD, often accompanied by occlusive bronchiolitis with organic pneumonia-like changes and significant multinucleated giant cells in the alveolar cavity. In patients with SARS-CoV and H5N1 infection, lymphocyte depletion in the spleen and lymph nodes, acute tubular necrosis, and hemophagocytic cells in the bone marrow were seen in the extrapulmonary organs.
Keywords: SARS-CoV-2; SARS-CoV; H1N1pdm09; H5N1.