[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
Am J Case Rep. 2019 May 21;20:723-725. doi: 10.12659/AJCR.915726.
Development of Secondary Microcephaly After Delivery: Possible Consequence of Mother-Baby Transmission of Zika Virus in Breast Milk.
Siqueira Mello A1, Pascalicchio Bertozzi APA2, Rodrigues MMD2, Gazeta RE2, Moron AF3, Soriano-Arandes A4, Sarmento SGP3, Vedovello D1, Silva ACB1, Grillo Fajardo TC1, Witkin SS5, Passos SD2,1.
Author information: 1 Laboratory of Pediatric Infectology, Department of Pediatrics, Jundiaí School of Medicine, São Paulo, SP, Brazil. 2 Department of Pediatrics, Jundiaí School of Medicine, São Paulo, SP, Brazil. 3 Department of Obstetrics, Federal University of São Paulo (UNIFESP) – Paulista School of Medicine and Paulista Center for Fetal Medicine, São Paulo, SP, Brazil. 4 Paediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d’Hebron, Barcelona, Spain. 5 Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York City, NY, USA.
The Zika virus is an arbovirus that has as main source of transmission the bite of infected insects of the genus Aedes and has been associated with cases of congenital malformation and microcephaly in neonates. However, other sources of transmission have been identified since the emergence of this virus in the world population, such as vertical transmission by semen and possibly other body fluids such as vaginal secretion and breast milk.
An infant, born to a mother whose previous delivery was a baby with severe microcephaly, was normal and was negative for Zika virus at birth but developed secondary microcephaly 1 month later, that persisted. The baby was exclusively breast-fed and Zika virus was present in the mother’s milk.
We report the detection of Zika virus exclusively in the breast milk of a woman after her second delivery of an infant, who later developed microcephaly. This case is consistent with possible vertical transmission.
PMID: 31110169 DOI: 10.12659/AJCR.915726
Keywords: Zika Virus; Pregnancy; Microcephaly.