[Source: PLoS Neglected Tropical Diseases, full page: (LINK). Abstract, edited.]
OPEN ACCESS / PEER-REVIEWED / RESEARCH ARTICLE
The characteristics of current natural foci of hemorrhagic fever with renal syndrome in Shandong Province, China, 2012-2015
Zhaolei Zheng, Peizhu Wang, Zhiqiang Wang, Dandan Zhang, Xu Wang, Shuqing Zuo, Xiujun Li
Published: May 20, 2019 / DOI: https://doi.org/10.1371/journal.pntd.0007148 / This is an uncorrected proof.
Hemorrhagic fever with renal syndrome (HFRS), an infectious disease caused by hantaviruses, is endemic in China and remains a serious public health problem. Historically, Shandong Province has had the largest HFRS burden in China. However, we do not have a comprehensive and clear understanding of the current epidemic foci of HFRS in Shandong Province.
The incidence and mortality rates were calculated, and a phylogenetic analysis was performed after laboratory testing of the virus in rodents. Spatial epidemiology analysis was applied to investigate the epidemic foci, including their sources. A total of 6,206 HFRS cases and 59 related deaths were reported in Shandong Province. The virus carriage rates of the rodents Rattus norvegicus, Apodemus agrarius and Mus musculus were 10.24%, 6.31% and 0.27%, respectively. The phylogenetic analysis indicated that two novel viruses obtained from R. norvegicus in Anqiu City and Qingzhou City were dissimilar to the other strains, but closely related to strains previously isolated in northeastern China. Three epidemic foci were defined, two of which were derived from the Jining and Linyi epidemic foci, respectively, while the other was the residue of the Jining epidemic focus.
The southeastern and central Shandong Province are current key HFRS epidemic foci dominated by A. agrarius and R. norvegicus, respectively. Our study could help local departments to strengthen prevention and control measures in key areas to reduce the hazards of HFRS.
Hemorrhagic fever with renal syndrome (HFRS) is a global infectious disease, which is still a serious public health threat in China today. The reported HFRS cases in Shandong Province accounted for approximate one third of total cases in the whole country. HFRS is a zoonosis mainly caused by Hantaan virus (HTNV) and Seoul virus (SEOV), which natural rodent hosts are A. agrarius and R. norvegicus, respectively. To explore the current HFRS epidemic foci based on patients, rodents and molecular epidemiology characteristics in Shandong Province, we collected the records of HFRS cases from whole province and the rodents captured in 14 surveillance sites. We found that the epidemic situation of HFRS is quiet different in temporal and spatial distribution. Three epidemic foci were defined based on patients, rodents and molecular epidemiology characteristics. The situation of HFRS epidemic foci in Shandong Province was clear. Our study provides a reference for relevant departments to develop key prevention strategies.
Citation: Zheng Z, Wang P, Wang Z, Zhang D, Wang X, Zuo S, et al. (2019) The characteristics of current natural foci of hemorrhagic fever with renal syndrome in Shandong Province, China, 2012-2015. PLoS Negl Trop Dis 13(5): e0007148. https://doi.org/10.1371/journal.pntd.0007148
Editor: David Joseph Diemert, George Washington University School of Medicine and Health Sciences, UNITED STATES
Received: January 3, 2019; Accepted: May 2, 2019; Published: May 20, 2019
Copyright: © 2019 Zheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: Some relevant data are within the manuscript and its Supporting Information files. The data of HFRS incidence and death underlying the results presented in the study are available from Shandong Provincial Center for Disease Control and Prevention (http://www.sdcdc.cn/col/col9776/index.html?uid=51587&pageNum=1).
Funding: This research was supported by the Natural Science Foundation of China (no. 81673238, 81473025), the Natural Science Foundation of Shandong Province (no. ZR2016HM75) and State Key Research Development Program of China (2016YFC1201902). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Keywords: Hantavirus; HFRS; Shandong; China.