#WNV #infection in individuals with pre-existing #Usutu virus #immunity, northern #Italy, 2018 (Euro Surveill., abstract)

[Source: Eurosurveillance, full page: (LINK). Abstract, edited.]

West Nile virus infection in individuals with pre-existing Usutu virus immunity, northern Italy, 2018

Alessandro Sinigaglia1, Monia Pacenti2, Thomas Martello1, Silvana Pagni1,2, Elisa Franchin1,2, Luisa Barzon1,2

Affiliations: 1 Department of Molecular Medicine, University of Padova, Padova, Italy; 2 Microbiology and Virology Unit, Padova University Hospital, Padova, Italy

Correspondence:  Luisa Barzon

Citation style for this article: Sinigaglia Alessandro, Pacenti Monia, Martello Thomas, Pagni Silvana, Franchin Elisa, Barzon Luisa. West Nile virus infection in individuals with pre-existing Usutu virus immunity, northern Italy, 2018. Euro Surveill. 2019;24(21):pii=1900261. https://doi.org/10.2807/1560-7917.ES.2019.24.21.1900261

Received: 27 Apr 2019;   Accepted: 22 May 2019

 

Abstract

In 2018, there was a large West Nile virus (WNV) outbreak in northern Italy. We observed five atypical cases of WNV infection that were characterised by the presence of WNV RNA and WNV IgG at the time of diagnosis, but no IgM response during follow-up. Neutralisation assays demonstrated pre-existing Usutu virus immunity in all patients. Besides challenging diagnosis, the immunological crosstalk between the two viruses warrants further investigation on possible cross-protection or infection enhancement effects.

©  This work is licensed under a Creative Commons Attribution 4.0 International License.

Keywords: WNV; Usutu virus; ADE; Italy.

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#Immigration in #Italy: the #medical #community’s role in #human #rights (Lancet, summary)

[Source: The Lancet, full page: (LINK). Summary, edited.]

Immigration in Italy: the medical community’s role in human rights

Raffaella Casolino

Published: May 20, 2019 / DOI: https://doi.org/10.1016/S0140-6736(19)30216-8

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Italy has been witnessing a rapid escalation towards racism and xenophobia since the new government came into power in June, 2018. On Nov 27, 2018, the lower house of the Italian Parliament approved the Decree-Law on Immigration and Security, which includes measures that would abolish humanitarian protection status for migrants, block asylum seekers from accessing reception centres focusing on social inclusion, and extend the duration of detention in return centres and hotspots. These measures fundamentally undermine international human rights principles. The day after approval, the Deputy Prime Minister and Minister of the Interior declared that Italy would not sign the UN Global Compact for Safe, Orderly and Regular Migration or take part in an intergovernmental conference in Marrakech, Morocco, on Dec 10, 2018.

(…)

I declare no competing interests.

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Reference

UN Human Rights, Office of the high commissioner. Legal changes and climate of hatred threaten migrants’ rights in Italy, say UN experts. URL: https://www.ohchr.org/en/NewsEvents/Pages/DisplayNews.aspx?NewsID=23908&LangID=E | Date: Nov 21, 2018 | Date accessed: November 28, 2018

 

Article Info

Published: May 20, 2019

Identification: DOI: https://doi.org/10.1016/S0140-6736(19)30216-8

Copyright © 2019 Elsevier Ltd. All rights reserved.

Keywords: Public Health; Society; Politics; Italy; Migrants; Racism.

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#Trends and correlates of #antimicrobial use in #broiler and turkey #farms: a #poultry company registry-based study in #Italy (J Antimicrob Chemother., abstract)

[Source: Journal of Antimicrobial Chemotherapy, full page: (LINK). Abstract, edited.]

Trends and correlates of antimicrobial use in broiler and turkey farms: a poultry company registry-based study in Italy

Claudia Caucci, Guido Di Martino, Alessandro Dalla Costa, Manuel Santagiuliana, Monica Lorenzetto, Katia Capello, Lapo Mughini-Gras, Luigi Gavazzi, Lebana Bonfanti

Journal of Antimicrobial Chemotherapy, dkz212, https://doi.org/10.1093/jac/dkz212

Published: 18 May 2019

 

Abstract

Background

Antimicrobial usage (AMU) in livestock plays a key role in the emergence and spread of antimicrobial resistance. Analysis of AMU data in livestock is therefore relevant for both animal and public health.

Objectives

To assess AMU in 470 broiler and 252 turkey farms of one of Italy’s largest poultry companies, accounting for around 30% of national poultry production, to identify trends and risk factors for AMU.

Methods

Antimicrobial treatments administered to 5827 broiler and 1264 turkey grow-out cycles in 2015–17 were expressed as DDDs for animals per population correction unit (DDDvet/PCU). A retrospective analysis was conducted to examine the effect of geographical area, season and prescribing veterinarian on AMU. Management and structural interventions implemented by the company were also assessed.

Results

AMU showed a 71% reduction in broilers (from 14 to 4 DDDvet/PCU) and a 56% reduction in turkeys (from 41 to 18 DDDvet/PCU) during the study period. Quinolones, macrolides and polymyxins decreased from 33% to 6% of total AMU in broilers, and from 56% to 32% in turkeys. Broiler cycles during spring and winter showed significantly higher AMU, as well as those in densely populated poultry areas. Different antimicrobial prescribing behaviour was identified among veterinarians.

Conclusions

This study evidenced a decreasing trend in AMU and identified several correlates of AMU in broilers and turkeys. These factors will inform the design of interventions to further reduce AMU and therefore counteract antimicrobial resistance in these poultry sectors.

Issue Section: ORIGINAL RESEARCH

© The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

Keywords: Antibiotics; Drugs Resistance; Poultry; Food Safety; Italy.

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High #incidence of #MDR and #XDR #Pseudomonas aeruginosa isolates obtained from #patients with #ventilator-associated #pneumonia in #Greece, #Italy and #Spain as part of the MagicBullet clinical trial (J Antimicrob Chemother., abstract)

[Source: Journal of Antimicrobial Chemotherapy, full page: (LINK). Abstract, edited.]

High incidence of MDR and XDR Pseudomonas aeruginosa isolates obtained from patients with ventilator-associated pneumonia in Greece, Italy and Spain as part of the MagicBullet clinical trial

Astrid Pérez, Eva Gato, José Pérez-Llarena, Felipe Fernández-Cuenca, María José Gude, Marina Oviaño, María Eugenia Pachón, José Garnacho, Verónica González, Álvaro Pascual, José Miguel Cisneros, Germán Bou

Journal of Antimicrobial Chemotherapy, dkz030, https://doi.org/10.1093/jac/dkz030

Published: 08 February 2019

 

Abstract

Objectives

To characterize the antimicrobial susceptibility, molecular epidemiology and carbapenem resistance mechanisms in Pseudomonas aeruginosa isolates recovered from respiratory tract samples from patients with ventilator-associated pneumonia enrolled in the MagicBullet clinical trial.

Methods

Isolates were collected from 53 patients from 12 hospitals in Spain, Italy and Greece. Susceptibility was determined using broth microdilution and Etest. MALDI-TOF MS was used to detect carbapenemase activity and carbapenemases were identified by PCR and sequencing. Molecular epidemiology was investigated using PFGE and MLST.

Results

Of the 53 isolates, 2 (3.8%) were considered pandrug resistant (PDR), 19 (35.8%) were XDR and 16 (30.2%) were MDR. Most (88.9%) of the isolates from Greece were MDR, XDR or PDR, whereas fewer of the isolates from Spain (33.3%) and Italy (43.5%) showed antibiotic resistance. Three Greek isolates were resistant to colistin. Overall, the rates of resistance of P. aeruginosa isolates to imipenem, ciprofloxacin, ceftolozane/tazobactam and ceftazidime/avibactam were 64.1%, 54.7%, 22.6% and 24.5%, respectively. All isolates resistant to ceftolozane/tazobactam and ceftazidime/avibactam (Greece, n = 10; and Italy, n = 2) carried blaVIM-2. Spanish isolates were susceptible to the new drug combinations. Forty-eight restriction patterns and 27 STs were documented. Sixty percent of isolates belonged to six STs, including the high-risk clones ST-111, ST-175 and ST-235.

Conclusions

MDR/XDR isolates were highly prevalent, particularly in Greece. The most effective antibiotic against P. aeruginosa was colistin, followed by ceftolozane/tazobactam and ceftazidime/avibactam. blaVIM-2 is associated with resistance to ceftolozane/tazobactam and ceftazidime/avibactam, and related to highly resistant phenotypes. ST-111 was the most frequent and disseminated clone and the clonal diversity was lower in XDR and PDR strains.

Topic: antibiotics – phenotype – polymerase chain reaction – pseudomonas aeruginosa – antibiotic resistance, bacterial – colistin – ciprofloxacin – ceftazidime – clone cells – drug combinations – electrophoresis, gel, pulsed-field – epidemiology, molecular – greece – ichthyosis, x-linked – imipenem – italy – respiratory system – sequence tagged sites – spain – spectrometry, mass, matrix-assisted laser desorption-ionization – sodium thiosulfate – antimicrobial susceptibility – tazobactam – ventilator-associated pneumonia – ceftolozane – avibactam – carbapenem resistance

Issue Section:

ORIGINAL RESEARCH

© The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

Keywords: Antibiotics; Drugs Resistance; Pseudomonas aeruginosa; Pneumonia; Italy; Spain; Greece; Colistin; Ciprofloxacin; Ceftazidime; Iminpenem; Tazobactam; Ceftolozane; Avibactam.

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Cocirculation of #Hajj and non-Hajj #strains among serogroup W #meningococci in #Italy, 2000 to 2016 (Euro Surveill., abstract)

[Source: Eurosurveillance, full page: (LINK). Abstract, edited.]

Cocirculation of Hajj and non-Hajj strains among serogroup W meningococci in Italy, 2000 to 2016

Cecilia Fazio1, Arianna Neri1, Paola Vacca1, Andrea Ciammaruconi2, Milena Arghittu3, Anna Maria Barbui4,Caterina Vocale5, Paola Bernaschi6, Patrizia Isola7, Irene Alessandra Galanti8, Antonella Mencacci9, Rosella De Nittis10, Maria Chironna11,Anna Giammanco12, Elisabetta Pagani13, Alessandro Bisbano14, Paola Stefanelli1

Affiliations: 1 Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy; 2 Molecular Biology Section, Army Medical and Veterinary Research Center, Rome, Italy; 3 Microbiology Unit, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy; 4 Microbiology and Virology Laboratory, Molinette Hospital, Turin, Italy; 5 Unit of Clinical Microbiology, Regional Reference Centre for Microbiological Emergencies, St. Orsola Malpighi University Hospital, Bologna, Italy; 6 Microbiology Laboratory, Bambino Gesù Hospital, Rome, Italy; 7 Clinical Pathology Department, Azienda USL 6, Livorno, Italy; 8 Microbiology Laboratory, Azienda USL Toscana sud est, Arezzo, Italy; 9 Medical Microbiology Section, Dept. of Medicine, University of Perugia, Perugia, Italy; 10 Clinical Pathology Department, University Hospital, Foggia, Italy; 11 Biomedical Sciences and Human Oncology Department – Hygiene Section, University Hospital, Bari, Italy; 12 Department of Sciences for Health Promotion and Mother and Child Care “G. D’Alessandro”, University of Palermo, Palermo, Italy; 13 Microbiology and Virology Laboratory, Azienda Sanitaria dell’Alto Adige, Bolzano, Italy; 14 Epidemiology Unit ASP Crotone, Italy

Correspondence:  Paola Stefanelli

Citation style for this article: Fazio Cecilia, Neri Arianna, Vacca Paola, Ciammaruconi Andrea, Arghittu Milena, Barbui Anna Maria, Vocale Caterina, Bernaschi Paola,Isola Patrizia, Galanti Irene Alessandra, Mencacci Antonella, De Nittis Rosella, Chironna Maria, Giammanco Anna, Pagani Elisabetta, Bisbano Alessandro, Stefanelli Paola. Cocirculation of Hajj and non-Hajj strains among serogroup W meningococci in Italy, 2000 to 2016. Euro Surveill. 2019;24(4):pii=1800183. https://doi.org/10.2807/1560-7917.ES.2019.24.4.1800183

Received: 11 Apr 2018;   Accepted: 23 Oct 2018

 

Abstract

In Italy, B and C are the predominant serogroups among meningococci causing invasive diseases. Nevertheless, in the period from 2013 to 2016, an increase in serogroup W Neisseria meningitidis (MenW) was observed. This study intends to define the main characteristics of 63 MenW isolates responsible of invasive meningococcal disease (IMD) in Italy from 2000 to 2016. We performed whole genome sequencing on bacterial isolates or single gene sequencing on culture-negative samples to evaluate molecular heterogeneity. Our main finding was the cocirculation of the Hajj and the South American sublineages belonging to MenW/clonal complex (cc)11, which gradually surpassed the MenW/cc22 in Italy. All MenW/cc11 isolates were fully susceptible to cefotaxime, ceftriaxone, ciprofloxacin, penicillin G and rifampicin. We identified the full-length NadA protein variant 2/3, present in all the MenW/cc11. We also identified the fHbp variant 1, which we found exclusively in the MenW/cc11/Hajj sublineage. Concern about the epidemic potential of MenW/cc11 has increased worldwide since the year 2000. Continued surveillance, supported by genomic characterisation, allows high-resolution tracking of pathogen dissemination and the detection of epidemic-associated strains.

©  This work is licensed under a Creative Commons Attribution 4.0 International License.

Keywords: Neisseria meningitidis sg W; Italy.

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#Incidence study of #GBS in the province of #Ferrara, Northern #Italy, between 2003 and 2017. A 40-year follow-up (Neurol Sci., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Neurol Sci. 2019 Jan 7. doi: 10.1007/s10072-018-3688-4. [Epub ahead of print]

Incidence study of Guillain-Barré syndrome in the province of Ferrara, Northern Italy, between 2003 and 2017. A 40-year follow-up.

Granieri E1, Andreasi NG2, De Martin P2, Govoni V2, Castellazzi M2, Cesnik E2, Pugliatti M2, Casetta I2.

Author information: 1 Department of Biomedical and Specialty-Surgical Sciences, Section of Neurology, Psychology and Psychiatry, University of Ferrara, Via Aldo Moro 8, 44124, Cona, Ferrara, Italy. enrico.granieri@unife.it. 2 Department of Biomedical and Specialty-Surgical Sciences, Section of Neurology, Psychology and Psychiatry, University of Ferrara, Via Aldo Moro 8, 44124, Cona, Ferrara, Italy.

 

Abstract

BACKGROUND:

Guillain-Barré syndrome (GBS) is an acute/subacute autoimmune inflammatory polyradiculoneuropathy. Previous epidemiological studies carried out in the province of Ferrara, Italy, from 1981 to 2002 indicated that GBS incidence had tendency of increase in the period considered.

OBJECTIVES:

We aimed at updating the epidemiology of GBS in the years 2003-2017 and carrying on the work started in the 1980s.

METHODS:

We conducted an incidence study, by adopting a complete enumeration approach. Cases were identified from administrative, medical records, and database of the Ferrara Hospital and other provincial structures of the study area. Case ascertainment and definition are analogous to those adopted in previous surveys.

RESULTS:

In the period 1 January 2003 to 31 December 2017, 73 patients living in the province of Ferrara (mean population 353,142) were found to be new cases of GBS fulfilling the NINCDS criteria. Male/female ratio 1.15. The mean incidence rate was 1.38 per 100,000 (95% CI 1.08-1.74), 1.54 per 100,000 for men and 1.23 per 100,000 for women, a nonsignificant difference. During the period considered, the rates had slow increase or mild decrease, without nonsignificant difference. The highest rates were observed for the age groups 70-79 years for both sexes. A half of patients reported infectious events in the weeks before the onset of symptoms.

CONCLUSION:

In line with many epidemiological data, in the whole period 2003-2017, we observed a trend towards increase or decrease in incidence and periods of relative stability. Similar temporal heterogeneity with the comparison to our previous works was found.

KEYWORDS: Epidemiology; Ferrara; Guillain-Barré syndrome; Incidence; Italy

PMID: 30617450 DOI: 10.1007/s10072-018-3688-4

Keywords: GBS; Neurology; Italy.

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Expanding #Usutu virus #circulation in #Italy: detection in the Lazio region, central Italy, 2017 to 2018 (Euro Surveill., abstract)

[Source: Eurosurveillance, full page: (LINK). Abstract, edited.]

Expanding Usutu virus circulation in Italy: detection in the Lazio region, central Italy, 2017 to 2018

Fabrizio Carletti1, Francesca Colavita1, Francesca Rovida2, Elena Percivalle2, Fausto Baldanti2,3, Ida Ricci4, Claudio De Liberato4, Francesca Rosone4, Francesco Messina1, Eleonora Lalle1, Licia Bordi1, Francesco Vairo5, Maria Rosaria Capobianchi1, Giuseppe Ippolito6, Giuseppina Cappiello7, Alberto Spanò7, Silvia Meschi1, Concetta Castilletti1

Affiliations: 1 Laboratory of Virology, National Institute for Infectious Diseases ‘Lazzaro Spallanzani’ IRCCS, Rome, Italy; 2 Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 3 Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Italy; 4 Istituto Zooprofilattico Sperimentale delle regioni Lazio e Toscana, Rome, Italy; 5 Regional Service for Surveillance and Control of Infectious Diseases (SERESMI)-Lazio Region, National Institute for Infectious Diseases ‘Lazzaro Spallanzani’ IRCCS, Rome, Italy; 6 Scientific Direction, National Institute for Infectious Diseases ‘Lazzaro Spallanzani’ IRCCS, Rome, Italy; 7 Unit of Microbiology, Sandro Pertini Hospital, Rome, Italy

Correspondence: Silvia Meschisilvia.meschiinmi.it

Citation style for this article: Carletti Fabrizio, Colavita Francesca, Rovida Francesca, Percivalle Elena, Baldanti Fausto, Ricci Ida, De Liberato Claudio, Rosone Francesca, Messina Francesco, Lalle Eleonora, Bordi Licia, Vairo Francesco, Capobianchi Maria Rosaria, Ippolito Giuseppe, Cappiello Giuseppina, Spanò Alberto, Meschi Silvia, Castilletti Concetta. Expanding Usutu virus circulation in Italy: detection in the Lazio region, central Italy, 2017 to 2018. Euro Surveill. 2019;24(3):pii=1800649. https://doi.org/10.2807/1560-7917.ES.2019.24.3.1800649

Received: 03 Dec 2018;   Accepted: 16 Jan 2019

 

Abstract

Blood donation screening for West Nile virus (WNV) was mandatory in the Lazio region in 2017 and 2018 (June-November) according to the national surveillance plan. In these years, all five donations reactive in WNV nucleic acid amplification tests harboured instead Usutu virus (USUV). Clade ‘Europe 2’ was identified in four blood donations and a 2018 mosquito pool. The cocirculation of WNV and USUV in Lazio warrants increased laboratory support and awareness of possible virus misidentification.

©  This work is licensed under a Creative Commons Attribution 4.0 International License.

Keywords: Arbovirus; Usutu Virus; WNV; Italy.

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