#GBS and its correlation with #dengue, #Zika and #chikungunya viruses #infection based on a literature review of reported cases in #Brazil (Acta Trop., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Acta Trop. 2019 Jun 17:105064. doi: 10.1016/j.actatropica.2019.105064. [Epub ahead of print]

Guillain-Barre Syndrome and its correlation with dengue, Zika and chikungunya viruses infection based on a literature review of reported cases in Brazil.

de Sousa Lima ME1, Rodrigues Bachur TP2, Frota Aragão G3.

Author information: 1 Curso de Medicina, Universidade Estadual do Ceará, Campus Itaperi, Av. Dr. Silas Munguba, 1700 – Itaperi, Fortaleza, CE, CEP 60.714-903, Brazil. Electronic address: matheus.eugenio@aluno.uece.br. 2 Curso de Medicina, Universidade Estadual do Ceará, Campus Itaperi, Av. Dr. Silas Munguba, 1700 – Itaperi, Fortaleza, CE, CEP 60.714-903, Brazil. Electronic address: tatiana.bachur@uece.br. 3 Curso de Medicina, Universidade Estadual do Ceará, Campus Itaperi, Av. Dr. Silas Munguba, 1700 – Itaperi, Fortaleza, CE, CEP 60.714-903, Brazil; Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Faculdade de Medicina, Universidade Federal do Ceará, Campus do Porangabuçu, Rua Cel. Nunes de Melo, 1000 – Rodolfo Teófilo, Fortaleza, CE, CEP 60.430-275, Brazil. Electronic address: gislei.frota@uece.br.



Guillain-Barre syndrome (GBS) is one of the main neurologic manifestations of arboviruses, especially Zika virus infection. As known, the prevalence of these diseases is high, so the risk of having an increase on GBS is relevant. The study purposes making a comparative survey between the involvement of dengue, Zika and chikungunya infections in the development of the GBS in Brazil, as well as search in literature resemblances and distinctions between beforehand reported cases. It was performed an electronic search in online databases, with articles published between the years of 2004 to 2018. A total of 729 articles about the proposed search were found, and 10 were selected according to inclusion and exclusion criteria. The medium age found in Brazilian studies was 42,9. The time lapse for the neurological symptoms manifest was 6,5 to 11 days. Facial palsy, paresthesia and member weakness were the main symptoms related. Pediatric cases are rare. There are many studies that implicated the association of GBS and arboviruses and point it to one of the main neurological manifestation of these infections. More research and consistent data are needed to clarify unanswered questions and guide public health measures.

Copyright © 2019. Published by Elsevier B.V.

KEYWORDS: Guillain-Barre syndrome; Zika virus; chikungunya; dengue fever

PMID: 31220435 DOI: 10.1016/j.actatropica.2019.105064

Keywords: Arbovirus; GBS; Chikungunya fever, Zika Virus, Dengue fever, Brazil.



#Phylogeography and #invasion history of #Aedes aegypti, the #Dengue and #Zika mosquito #vector in #CapeVerde islands (West Africa) (Evol Appl., abstract)

[Source: Evolutionary Applications, full page: (LINK). Abstract, edited.]


Phylogeography and invasion history of Aedes aegypti, the Dengue and Zika mosquito vector in Cape Verde islands (West Africa)

Patrícia Salgueiro,  Célia Serrano,  Bruno Gomes,  Joana Alves,  Carla A. Sousa,  Ana Abecasis, João Pinto

First published: 20 June 2019 / DOI:  https://doi.org/10.1111/eva.12834

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/eva.12834



Aedes‐borne arboviruses have spread globally with outbreaks of vast impact on human populations and health systems. The West African archipelago of Cape Verde had its first outbreak of Dengue in 2009, at the time the largest recorded in Africa, and was one of the few African countries affected by the Zika virus epidemic. Aedes aegypti was the mosquito vector involved in both outbreaks. We performed a phylogeographic and population genetics study of A. aegypti in Cape Verde in order to infer the geographic origin and evolutionary history of this mosquito. These results are discussed with respect to the implications for vector control and prevention of future outbreaks. Mosquitoes captured before and after the Dengue outbreak on the islands of Santiago, Brava and Fogo were analyzed with two mitochondrial genes COI and ND4, 14 microsatellite loci and five kdr mutations. Genetic variability was comparable to other African populations. Our results suggest that A. aegypti invaded Cape Verde at the beginning of the Holocene from West Africa. Given the historic importance of Cape Verde in the transatlantic trade of the 16th –17th centuries, a possible contribution to the genetic pool of the founding populations in the New World cannot be fully discarded. However, contemporary gene flow with the Americas is likely to be infrequent. No kdr mutations associated with pyrethroid resistance were detected. The implications for vector control and prevention of future outbreaks are discussed.

This article is protected by copyright. All rights reserved.

Keywords: Mosquitoes: Arbovirus; Zika virus; Dengue Fever; Cape Verde; Evolution; Aedes aegypti.


#Dengue Virus in #Bats from Córdoba and Sucre, #Colombia (Vector Borne Zoo Dis., abstract)

[Source: Vector Borne and Zoonotic Diseases, full page: (LINK). Abstract, edited.]

Dengue Virus in Bats from Córdoba and Sucre, Colombia

Alfonso Calderón, Camilo Guzmán, Salim Mattar, Virginia Rodriguez, Caty Martínez, Lina Violet, Jairo Martínez, and Luiz Tadeu Moraes Figueiredo

Published Online: 18 Jun 2019 / DOI: https://doi.org/10.1089/vbz.2018.2324



Natural infection of dengue virus (DENV) in bats is an unexplored field in Colombia. To detect the presence of DENV in bats, a descriptive prospective study using a nonprobabilistic sampling was carried out; 286 bats in 12 sites were caught. Sample tissues of different animals were obtained; the RNA was obtained from tissues and a nested-RT-PCR was carried out and detected amplicons of 143 fragment of the NS5 gene were sequenced by the Sanger method. In nonhematophagous bats Carollia perspicillata and Phyllostomus discolor captured in Ayapel and San Carlos (Córdoba), respectively, an amplicon corresponding to NS5 was detected. The amplicons showed a high similarity with serotype-2 dengue virus (DENV-2). This is the first evidence of the DENV-2 genome in bats in from the Colombian Caribbean.

Keywords: Dengue fever; Bats; Colombia.


#Kidney Diseases Associated With #Parvovirus B19, #Hanta, #Ebola, and #Dengue Virus #Infection: A Brief #Review (Adv Chronic Kidney Dis., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Adv Chronic Kidney Dis. 2019 May;26(3):207-219. doi: 10.1053/j.ackd.2019.01.006.

Kidney Diseases Associated With Parvovirus B19, Hanta, Ebola, and Dengue Virus Infection: A Brief Review.

Prasad N1, Novak JE2, Patel MR3.

Author information: 1 Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. Electronic address: narayan.nephro@gmail.com. 2 Division of Nephrology, Henry Ford Hospital, Detroit, MI. 3 Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.



Viral infection-associated kidney diseases are an emerging public health issue in both developing and developed countries. Many new viruses have emerged with new paradigms of kidney injury, either directly through their cytopathic effect or indirectly through immune-mediated glomerulopathy, tubulointerstitial disease, and acute kidney injury as part of multiorgan failure. Herein, we will discuss Parvovirus, which causes glomerulopathy, and Hanta, Ebola, and Dengue viruses, which cause viral hemorrhagic fever and acute kidney injury. Clinical manifestations also depend on extrarenal organ systems involved. Diagnosis of these viral infections is mainly based on a high index of suspicion, serologic testing, and isolation of viral DNA/RNA. Management is largely conservative, as specific antiviral agents are unavailable.

Copyright © 2019 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

KEYWORDS: Acute kidney injury; Glomerular disease; Viral hemorrhagic fever; Virus-associated kidney disease

PMID: 31202393 DOI: 10.1053/j.ackd.2019.01.006

Keywords: Acute kidney injury; Hantavirus; Parvovirus; Dengue Fever; Ebola.


First report of collapsing variant of focal segmental #glomerulosclerosis triggered by #arbovirus: #dengue and #Zika virus #infection (Clin Kidney J., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Clin Kidney J. 2018 Nov 19;12(3):355-361. doi: 10.1093/ckj/sfy104. eCollection 2019 Jun.

First report of collapsing variant of focal segmental glomerulosclerosis triggered by arbovirus: dengue and Zika virus infection.

Araújo SA1,2, Cordeiro TME2, Belisário AR2, Araújo RFA1,2, Marinho PES3, Kroon EG3, de Oliveira DB4, Teixeira MM2,5, Simões E Silva AC2.

Author information: 1 Instituto de Nefro Patologia, Belo Horizonte, Brazil. 2 Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Brazil. 3 Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. 4 Faculdade de Medicina de Diamantina, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil. 5 National Institute of Science and Technology in Dengue, Laboratory of Immunopharmacology, Institute of Biological Sciences, UFMG, Brazil.




The collapsing variant of focal segmental glomerulosclerosis (FSGS) is the most aggressive form of FSGS and is characterized by at least one glomerulus with segmental or global collapse and overlying podocyte hypertrophy and hyperplasia. Viruses can act as aetiological agents of secondary FSGS. This study aims to establish an aetiological link between dengue virus (DENV) infection and the collapsing variant of FSGS and to analyse possible influences of the apolipoprotein 1 (APOL1) gene risk alleles on the disease.


Biopsies and medical records were gathered from 700 patients of the Instituto de Nefropatologia, Belo Horizonte, Brazil. Screening for the collapsing variant of FSGS was performed and serological, immunohistochemical, tissue polymerase chain reaction (PCR) and genetic analysis were conducted.


Eight patients were identified with positive DENV serology and negative serological and/or tissue markers for hepatitis B virus, hepatitis C virus, Epstein-Barr virus, human immunodeficiency virus, cytomegalovirus and parvovirus B19. In PCR analysis, six patients had positive markers for DENV strain genetic material, one patient had positive markers for co-infection of Zika virus (ZIKV) and DENV and one patient had positive markers only for ZIKV infection. Six of the eight patients did not show risk alleles of the APOL1 gene. One patient had only one risk allele (G1) and the sample from another did not contain enough DNA for genetic analysis to be performed.


This study provided strong evidence that DENV can infect renal tissue and possibly functions as a second hit to the development of the collapsing variant of FSGS. Nonetheless, this study also highlights the possible implication of ZIKV infection in FSGS and supports the argument that risk alleles of the APOL1 gene may not be implicated in the susceptibility to FSGS in these patients.

KEYWORDS: arbovirus; chronic kidney disease; dengue infection; focal segmental glomerulosclerosis; renal histopahology

PMID: 31198534 PMCID: PMC6543975 DOI: 10.1093/ckj/sfy104

Keywords: Arbovirus; Flavivirus; Dengue fever; Zika Virus; Brazil.


#Asymptomatic #Dengue Virus Infections, #Cambodia, 2012–2013 (Emerg Infect Dis., abstract)

[Source: US Centers for Disease Control and Prevention (CDC), Emerging Infectious Diseases Journal, full page: (LINK). Abstract, edited.]

Volume 25, Number 7—July 2019 / Research

Asymptomatic Dengue Virus Infections, Cambodia, 2012–2013

Sowath Ly1, Camille Fortas1, Veasna Duong, Tarik Benmarhnia, Anavaj Sakuntabhai, Richard Paul, Rekol Huy, Sopheak Sorn, Kunthy Nguon, Siam Chan, Souv Kimsan, Sivuth Ong, Kim Srorn Kim, Sowathy Buoy, Lim Voeung, Philippe Dussart, Philippe Buchy1, and Arnaud Tarantola1

Author affiliations: Institut Pasteur du Cambodge, Phnom Penh, Cambodia (S. Ly, C. Fortas, V. Duong, S. Sorn, K. Nguon, S. Chan, S. Kimsan, S. Ong, P. Dussart, P. Bucky, A. Tarantola); University of California, San Diego, California, USA (T. Benmarhnia); Institut Pasteur, Paris, France (A. Sakuntabhai, R. Paul); Malaria National Center, Phnom Penh (R. Huy); Kampong Cham Provincial Hospital, Kampong Cham, Cambodia (K.S. Kim); Prey Chhor District Referral Hospital, Kampong Cham (S. Buoy); Tboung Khmum District Referral Hospital, Thoung Khmum, Cambodia (L. Voeung); GlaxoSmithKline Vaccines Research and Design, Singapore (P. Buchy)



We investigated dengue virus (DENV) and asymptomatic DENV infections in rural villages of Kampong Cham Province, Cambodia, during 2012 and 2013. We conducted perifocal investigations in and around households for 149 DENV index cases identified through hospital and village surveillance. We tested participants from 0.5–30 years of age by using nonstructural 1 rapid tests and confirmed DENV infections using quantitative reverse transcription PCR or nonstructural 1–capture ELISA. We used multivariable Poisson regressions to explore links between participants’ DENV infection status and household characteristics. Of 7,960 study participants, 346 (4.4%) were infected with DENV, among whom 302 (87.3%) were <15 years of age and 225 (65.0%) were <9 years of age. We identified 26 (7.5%) participants with asymptomatic DENV infection at diagnosis and during follow-up. We linked symptomatic DENV infection status to familial relationships with index cases. During the 2-year study, we saw fewer asymptomatic DENV infections than expected based on the literature.

Keywords: Dengue fever; Cambodia.


Co-circulation of #dengue, #chikungunya, and #Zika viruses in #Colombia from 2008 to 2018 (Rev Panam Salud Publica, abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Rev Panam Salud Publica. 2019 Jun 7;43:e49. doi: 10.26633/RPSP.2019.49. eCollection 2019.

Co-circulation of dengue, chikungunya, and Zika viruses in Colombia from 2008 to 2018.

Rico-Mendoza A1, Alexandra PR1, Chang A2, Encinales L3, Lynch R4.

Author information: 1 Grupo de Medicina Comunitaria y Salud Colectiva Grupo de Medicina Comunitaria y Salud Colectiva Universidad El Bosque Bogotá Colombia Grupo de Medicina Comunitaria y Salud Colectiva, Universidad El Bosque, Bogotá, Colombia. 2 Department of Medicine, the George Washington University Department of Medicine, the George Washington University WashingtonD.C United States of America Department of Medicine, the George Washington University, Washington, D.C., United States of America. 3 Allied Research Society Allied Research Society BarranquillaAtlántico Colombia Allied Research Society, Barranquilla, Atlántico, Colombia. 4 Department of Microbiology, Immunology, and Tropical Medicine, the George Washington University Department of Microbiology, Immunology, and Tropical Medicine, the George Washington University WashingtonD.C United States of America Department of Microbiology, Immunology, and Tropical Medicine, the George Washington University, Washington, D.C., United States of America.

Abstract in English, Portuguese, Spanish


This study aimed to identify the co-circulation patterns of three viruses (dengue, Zika, and -chikungunya) in Colombia from 2008 to 2018 by using notification reports provided to the national surveillance system.


This cross-sectional study was conducted through a review of data for 2008 through 2018 from Colombia’s Public Health Surveillance System (SIVIGILA).


In 2015, when chikungunya was first detected, it had a higher incidence (1 359.0 cases per 100 000 persons) than did the two other diseases. In 2016, when the circulation of Zika virus was first found, the incidence was 296.4 cases per 100 000 persons; that incidence declined dramatically in the next two years. Between 2015 and 2018, there was a substantial decrease in the frequency of dengue circulation, with it going from 334.1 cases per 100 000 persons in 2015 to 90.7 cases per 100 000 in 2017 and 173.1 cases per 100 000 in 2018.


The decrease in the number of dengue cases after co-circulation of the three viruses could indicate possible cross-protection. This finding should be further analyzed.

KEYWORDS: Colombia; Zika virus; chikungunya virus; coinfection; dengue virus

PMID: 31171921 PMCID: PMC6548069 DOI: 10.26633/RPSP.2019.49

Keywords: Chikungunya fever; Zika Virus; Dengue Fever; Colombia.