[Source: Virologica Sinica, full page: (LINK). Abstract, edited.]
Association of Allergic Symptoms with Dengue Infection and Severity: A Systematic Review and Meta-analysis
Authors: Nguyen Dang Kien, Amr Ehab El-Qushayri, Ali Mahmoud Ahmed, Adnan Safi, Sarch Abdel Mageed, Samar Muhammed Mehyar, Mohammad Rashidul Hashan, Sedighe Karimzadeh, Kenji Hirayama, Nguyen Tien Huy
RESEARCH ARTICLE / First Online: 21 October 2019
The relationship between the severity of dengue infection and allergy is still obscure. We conducted an electronic search across 12 databases for relevant articles reporting allergic symptoms, dengue infection, and dengue classification. These studies were categorized according to dengue severity and allergy symptoms, and a meta-analysis was performed by pooling the studies in each category. Among the included 57 articles, pruritus was the most common allergic sign followed by non-specified allergy and asthma (28.6%, 13%, and 6.5%, respectively). Despite the reported significant association of dengue with pruritus and total IgE level (P < 0.05), in comparison with non-dengue cases and healthy controls, there was no association between the different severe dengue group with pruritus, skin allergy, food allergy or asthma. However, removing the largest study revealed a significant association between asthma with dengue hemorrhagic fever (DHF) rather than dengue fever (DF). In comparison with DF, DHF was associated with IgE positivity. Furthermore, specific-IgE level was higher in secondary DF rather than primary DF. There was a possible association between allergy symptoms and dengue severity progression. Further studies are needed to clarify this association.
Keywords: Dengue – Allergy – Severity – IgE – Asthma – Association
Nguyen Dang Kien, Amr Ehab El-Qushayri and Ali Mahmoud Ahmed have contributed equally to this work.
Electronic supplementary material
The online version of this article ( https://doi.org/10.1007/s12250-019-00165-6) contains supplementary material, which is available to authorized users.
We acknowledged the contributions of Nguyen Thi Huyen Trang (Hue University of Medicine and Pharmacy, Hue City, Vietnam), Nguyen Phuoc Long, Le Phi Hung, and Nguyen Thien Luan (University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam), Tran Thi Minh Hue (Hanoi Medical University, Vietnam) Doan Ngoc Dinh (Health Strategy and Policy Institute (HSPI),MoH Vietnam), Tran Dinh Trung (Da Nang University of Medical Technology and Pharmacy, Da Nang City, Vietnam) on the initial work of the study.
NDK, AEE, AMA and NTH designed the experiments. NDK, AEE, AMA, AS, SAM, SMM, SK, MRH and KH collected the documents and summed up the data. NDK, AEE, AMA and NTH analyzed the data. NDK, AEE, AMA and NTH wrote the manuscript. All author read and approved the final manuscript.
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
Animal and Human Rights Statement
This article does not contain any studies with human or animal subjects performed by any of the authors.
Keywords: Dengue fever; Allergy.