[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
Acta Trop. 2019 Jun 17:105064. doi: 10.1016/j.actatropica.2019.105064. [Epub ahead of print]
Guillain-Barre Syndrome and its correlation with dengue, Zika and chikungunya viruses infection based on a literature review of reported cases in Brazil.
de Sousa Lima ME1, Rodrigues Bachur TP2, Frota Aragão G3.
Author information: 1 Curso de Medicina, Universidade Estadual do Ceará, Campus Itaperi, Av. Dr. Silas Munguba, 1700 – Itaperi, Fortaleza, CE, CEP 60.714-903, Brazil. Electronic address: email@example.com. 2 Curso de Medicina, Universidade Estadual do Ceará, Campus Itaperi, Av. Dr. Silas Munguba, 1700 – Itaperi, Fortaleza, CE, CEP 60.714-903, Brazil. Electronic address: firstname.lastname@example.org. 3 Curso de Medicina, Universidade Estadual do Ceará, Campus Itaperi, Av. Dr. Silas Munguba, 1700 – Itaperi, Fortaleza, CE, CEP 60.714-903, Brazil; Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Faculdade de Medicina, Universidade Federal do Ceará, Campus do Porangabuçu, Rua Cel. Nunes de Melo, 1000 – Rodolfo Teófilo, Fortaleza, CE, CEP 60.430-275, Brazil. Electronic address: email@example.com.
Guillain-Barre syndrome (GBS) is one of the main neurologic manifestations of arboviruses, especially Zika virus infection. As known, the prevalence of these diseases is high, so the risk of having an increase on GBS is relevant. The study purposes making a comparative survey between the involvement of dengue, Zika and chikungunya infections in the development of the GBS in Brazil, as well as search in literature resemblances and distinctions between beforehand reported cases. It was performed an electronic search in online databases, with articles published between the years of 2004 to 2018. A total of 729 articles about the proposed search were found, and 10 were selected according to inclusion and exclusion criteria. The medium age found in Brazilian studies was 42,9. The time lapse for the neurological symptoms manifest was 6,5 to 11 days. Facial palsy, paresthesia and member weakness were the main symptoms related. Pediatric cases are rare. There are many studies that implicated the association of GBS and arboviruses and point it to one of the main neurological manifestation of these infections. More research and consistent data are needed to clarify unanswered questions and guide public health measures.
Copyright © 2019. Published by Elsevier B.V.
KEYWORDS: Guillain-Barre syndrome; Zika virus; chikungunya; dengue fever
PMID: 31220435 DOI: 10.1016/j.actatropica.2019.105064
Keywords: Arbovirus; GBS; Chikungunya fever, Zika Virus, Dengue fever, Brazil.