[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
Int J Infect Dis. 2019 Feb 11. pii: S1201-9712(19)30060-8. doi: 10.1016/j.ijid.2019.01.047. [Epub ahead of print]
Postmortem evidence of disseminated Zika virus infection in an adult patient.
Rajahram GS1, Hale G2, Bhatnagar J2, Hiu J3, Thayan R4, William T5, Wong KT6, Tambyah PA7, Yeo TW8.
Author information: 1 Infectious Diseases Unit, Department of Medicine, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia; Clinical Research Centre, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia. 2 Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. 3 Department of Forensic Medicine, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia. 4 Virology Unit, Infectious Disease Research Centre, Institute of Medical Research, Kuala Lumpur, Malaysia. 5 Jesselton Medical Centre, Kota Kinabalu, Sabah Malaysia. 6 Department of Pathology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia. 7 Department of Medicine, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore. 8 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore.
Zika virus infections in immunocompetent adults typically are asymptomatic or cause mild symptoms, but have also been associated with neurological complications including Guillain-Barre Syndrome. Zika virusassociated non-neurological fatalities in adults are rare. Herein, we describe a decedent with multiple commodities who developed an acute febrile illness with rash days prior to death. A post-mortem evaluation detected molecular evidence of disseminated Zika virus. Further testing by Zika virus in-situ hybridization identified genomic and replicative Zika viral RNA in renal tubular epithelial cells, and cardiomyocytes, providing insights into organ-specific viral reservoirs.
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
KEYWORDS: Zika Virus Post-Mortem Myocarditis Renal Tubule In-situ hybridisation
PMID: 30763620 DOI: 10.1016/j.ijid.2019.01.047
Keywords: Zika Virus.