[Source: Journal of Infectious Diseases, full page: (LINK). Abstract, edited.]
What is the Value of Different Zika Vaccination Strategies to Prevent and Mitigate Zika Outbreaks
Sarah M Bartsch, MPH, Lindsey Asti, MPH, Sarah Cox, MSPH, David P Durham, PhD, Samuel Randall, Peter J Hotez, MD, PhD, Alison P Galvani, PhD, Bruce Y Lee, MD, MBA
The Journal of Infectious Diseases, jiy688, https://doi.org/10.1093/infdis/jiy688
Published: 13 December 2018
While the 2015–2016 Zika epidemics prompted accelerated vaccine development, decision makers need to know the potential economic value of vaccination strategies.
We developed models of Honduras, Brazil, and Puerto Rico, simulated targeting different populations for Zika vaccination (women of childbearing age, school-aged children, young adults, and everyone) and then introduced various Zika outbreaks. Sensitivity analyses varied vaccine characteristics.
With a 2% attack rate ($5 vaccination), compared to no vaccination, vaccinating women of childbearing age cost $314–1664 per case averted ($790–4,221/DALY averted) in Honduras, and saved $847–1,644/case averted in Brazil, and $3,648–4,177/case averted in Puerto Rico, varying with vaccination coverage and efficacy (societal perspective). Vaccinating school-aged children cost $718–1,849/case averted ($5,002/DALY averted) in Honduras, saved $819–1,609/case averted in Brazil, and saved $3,823–4,360/case averted in Puerto Rico. Vaccinating young adults cost $310–1,666/case averted ($731–4,017/DALY averted) in Honduras, saved $953–1,703/case averted in Brazil, and saved $3,857–4,372/case averted in Puerto Rico. Vaccinating everyone averted more cases but cost more, decreasing cost-savings per case averted. Vaccination resulted in more cost-savings and better outcomes at higher attack rates.
When considering transmission, while vaccinating everyone naturally averted the most cases, specifically targeting women of childbearing age or young adults was the most cost-effective.
firstname.lastname@example.org, Zika, Cost-Effectiveness, Vaccine
Topic: – cost effectiveness – brazil – cost savings – disease outbreaks – honduras – puerto rico – vaccination – vaccines – disability-adjusted life-year – attack rate – young adult – school-age child – zika virus – zika virus disease – zika vaccine
Issue Section: Major Article
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: email@example.com.
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
Keywords: Zika Virus; Vaccines.