#Vector-borne #transmission of #Zika virus in #Europe, southern #France, August 2019 (Euro Surveill., abstract)

[Source: Eurosurveillance, full page: (LINK). Abstract, edited.]

Vector-borne transmission of Zika virus in Europe, southern France, August 2019

Sandra Giron1, Florian Franke1, Anne Decoppet2, Bernard Cadiou3, Thierry Travaglini3, Laurence Thirion4, Guillaume Durand4,5, Charles Jeannin3, Grégory L’Ambert3, Gilda Grard4,5, Harold Noël6, Nelly Fournet6, Michelle Auzet-Caillaud2, Christine Zandotti5, Samer Aboukaïs2, Pascal Chaud1, Saby Guedj7, Lakri Hamouda7, Xavier Naudot8, Anne Ovize8, Clément Lazarus9, Henriette de Valk6, Marie-Claire Paty6, Isabelle Leparc-Goffart4,5

Affiliations: 1 Santé publique France (French National Public Health Agency), Marseille, France; 2 Regional Health Agency of Provence-Alpes-Côtes d’Azur (ARS Paca), Marseille, France; 3 Entente interdépartementale pour la démoustication du littoral méditerranéen (EID Méditerranée), Montpellier, France; 4 Unité des Virus Emergents (UVE: Aix-Marseille Univ – IRD 190 – Inserm 1207 – IHU Méditerranée Infection), Marseille, France; 5 Institut de Recherche Biomédicale des Armées, National Reference Laboratory for Arboviruses, Marseille, France; 6 Santé publique France (French National Public Health Agency), Saint-Maurice, France; 7 Médecin généraliste, Hyères, France; 8 Eurofins Biomnis, Lyon, France; 9 Public Health Emergency Operations Centre, Division of Surveillance and Health Security, Ministry of Health, General Directorate for Health, Health Emergencies Crisis Management Centre, Paris, France

Correspondence:  Harold Noel

Citation style for this article: Giron Sandra, Franke Florian, Decoppet Anne, Cadiou Bernard, Travaglini Thierry, Thirion Laurence, Durand Guillaume, Jeannin Charles, L’Ambert Grégory, Grard Gilda, Noël Harold, Fournet Nelly, Auzet-Caillaud Michelle, Zandotti Christine, Aboukaïs Samer, Chaud Pascal, Guedj Saby, Hamouda Lakri, Naudot Xavier, Ovize Anne, Lazarus Clément, de Valk Henriette, Paty Marie-Claire, Leparc-Goffart Isabelle. Vector-borne transmission of Zika virus in Europe, southern France, August 2019. Euro Surveill. 2019;24(45):pii=1900655. https://doi.org/10.2807/1560-7917.ES.2019.24.45.1900655

Received: 29 Oct 2019;   Accepted: 07 Nov 2019

 

Abstract

On 1 October 2019, a locally-acquired Zika virus disease case was laboratory confirmed in Hyères, Var department. Active case finding identified two additional locally-acquired cases living within 90 m, with symptom onset 8 days before the index case. Extensive patient interviews did not yield information supporting transmission through sexual contact or substances of human origin. Vector-borne transmission by local Aedes albopictus mosquitoes is the most likely mode of transmission. Here we describe the public health response.

©  This work is licensed under a Creative Commons Attribution 4.0 International License.

Keywords: Zika Virus; France.

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#Human #Infection with #Orf Virus and Description of Its Whole #Genome, #France, 2017 (Emerg Infect Dis., abstract)

[Source: US Centers for Disease Control and Prevention (CDC), Emerging Infectious Diseases Journal, full page: (LINK). Abstract, edited.]

Volume 25, Number 12—December 2019 / Research

Human Infection with Orf Virus and Description of Its Whole Genome, France, 2017

Julien Andreani, Jessica Fongue, Jacques Y. Bou Khalil, Laurene David, Saïd Mougari, Marion Le Bideau, Jonatas Abrahão, Philippe Berbis, and Bernard La Scola

Author affiliations: Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France (J. Andreani, J.Y. Bou Khalil, S. Mougari, M. Le Bideau, B. La Scola); Centre Hospitalier Universitaire Hôpital Nord, Marseille (J. Fongue, L. David, P. Berbis); Universidade Federal de Minas Gerais, Belo Horizonte, Brazil (J. Abrahão)

 

Abstract

Zoonotic transmission of parapoxvirus from animals to humans has been reported; clinical manifestations are skin lesions on the fingers and hands after contact with infected animals. We report a human infection clinically suspected as being ecthyma contagiosum. The patient, a 65-year-old woman, had 3 nodules on her hands. She reported contact with a sheep during the Aïd-el-Fitr festival in France during 2017. We isolated the parapoxvirus orf virus from these nodules by using a nonconventional cell and sequenced the orf genome. We identified a novel orf virus genome and compared it with genomes of other orf viruses. More research is needed on the genus Parapoxvirus to understand worldwide distribution of and infection by orf virus, especially transmission between goats and sheep.

Keywords: Parapoxvirus; Orf virus; Human; France.

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#Incidence, characteristics, and #mortality of infective #endocarditis in #France in 2011 (PLOS One, abstract)

[Source: PLOS One, full page: (LINK). Abstract, edited.]

OPEN ACCESS /  PEER-REVIEWED / RESEARCH ARTICLE

Incidence, characteristics, and mortality of infective endocarditis in France in 2011

S. Sunder , L. Grammatico-Guillon  , A. Lemaignen, M. Lacasse, C. Gaborit, D. Boutoille, P. Tattevin, E. Denes, T. Guimard, M. Dupont, L. Fauchier, L. Bernard

___

Published: October 25, 2019 / DOI: https://doi.org/10.1371/journal.pone.0223857

 

Abstract

Objectives

We assessed the determinants of mortality in infective endocarditis (IE), using the national hospital discharge databases (HDD) in 2011.

Methods

IE stays were extracted from the national HDD, with a definition based on IE-related diagnosis codes. This definition has been assessed according to Duke criteria by checking a sample of medical charts of IE giving a predictive positive value of 86.1% (95% confidence interval (CI): 82.7% – 89.5%). The impact of heart valve surgery on survival has been studied if performed during the initial stay, and over the year of follow-up. Risk factors of in-hospital mortality were identified using logistic regression model for the initial stay and Cox Time-dependent model for the 1-year mortality.

Results

The analysis included 6,235 patients. The annual incidence of definite IEs was 63 cases/million residents. Staphylococci and Streptococci were the most common bacteria (44% and 45%, respectively). A valvular surgery was performed in 20% of cases, but substantial variations existed between hospitals. The in-hospital mortality was 21% (ranging 12% to 27% according to the region of patients), associated with age>70, chronic liver disease, renal failure, S. aureus, P. aeruginosa or candida infection and strokes whereas valvular surgery, a native valve IE or intraveinous drug use (right heart IE) were significantly protective for an initial death. The same factors were associated with the one-year mortality, except for valvular surgery which was associated with a 1.4-fold higher risk of death during the year post IE.

Conclusion

We reported a high IE incidence rate. Valvular surgery was considerably less frequent in this study than in the previous published data (near 50%) whereas mortality was similar. Surgery was associated with higher survival if undergone within the initial stay. There were significant regional differences in frequency of surgery but it did not impact mortality.

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Citation: Sunder S, Grammatico-Guillon L, Lemaignen A, Lacasse M, Gaborit C, Boutoille D, et al. (2019) Incidence, characteristics, and mortality of infective endocarditis in France in 2011. PLoS ONE 14(10): e0223857. https://doi.org/10.1371/journal.pone.0223857

Editor: Dafna Yahav, Rabin Medical Center, Beilinson Hospital, ISRAEL

Received: May 23, 2019; Accepted: September 30, 2019; Published: October 25, 2019

Copyright: © 2019 Sunder et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Data Availability: Data cannot be shared publicly because of the restricted access of the national health medico-administrative databases. The Database is only allowed and built according to a protocol agreement (+IRB and ethic statement) and the access is secured on a dedicated web platform of the ATIH (Agence Technique de L’information Médicale). The data are available for the researchers in charge of the study only on the platform; analyzes are done on it and no data could be extracted; only the aggregated results and statistics. However, the data underlying the results presented in the study are available from the ATIH (French agency for the medico-administrative health data) after obtaining the authorization. Hence, researchers who meet the criteria for access to confidential data could apply our algorithm and perform the same analyzes as we did after agreement. Hence, the contact information for a non-author point of contact at the ATIH where interested researchers may request access to the data underlying the results is the following demande_base@atih.sante.fr and the procedure to follow are exposed on their website: https://www.atih.sante.fr/bases-de-donnees/commande-de-bases.

Funding: The author(s) received no specific funding for this work.

Competing interests: The authors have declared that no competing interests exist.

Keywords: Endocarditis; France.

—–

#Oseltamivir #resistance in #severe #influenza A #H1N1pdm09 #pneumonia and #ARDS: a #French multicenter observational cohort study (Clin Infect Dis., abstract)

[Source: Clinical Infectious Diseases Journal, full page: (LINK). Abstract, edited.]

Clin Infect Dis. 2019 Sep 20. pii: ciz904. doi: 10.1093/cid/ciz904. [Epub ahead of print]

Oseltamivir resistance in severe influenza A(H1N1)pdm09 pneumonia and acute respiratory distress syndrome: a French multicenter observational cohort study.

Behillil S1, May F2,3, Fourati S4, Luyt CE5, Chicheportiche T5, Sonneville R6, Tandjaoui-Lambiotte Y7, Roux D8, Guérin L9, Mayaux J10, Maury E11, Ferré A12, Georger JF13, Voiriot G14, Enouf V1, van der Werf S1, Dessap AM2,3, de Prost N2,3.

Author information: 1 Unité de Génétique Moléculaire des Virus à ARN et Centre National de Référence des Virus des Infections Respiratoires (dont la grippe), Institut Pasteur, Université Paris Diderot, Sorbonne Paris Cité, Paris, France. 2 Service de Réanimation Médicale, Hôpitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-Hôpitaux de Paris, Créteil, France. 3 Groupe de Recherche Clinique CARMAS, Université Paris-Est Créteil, IMRB, Créteil,  France. 4 Département de Microbiologie, Hôpitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-Hôpitaux de Paris, Créteil, France. 5 Service de Médecine Intensive Réanimation, Hôpital de La Pitié Salpétrière, Assistance Publique-Hôpitaux de Paris, Paris, France. 6 Service de Médecine Intensive Réanimation, Hôpital Bichat Claude Bernard, Assistance Publique-Hôpitaux de Paris, Paris, France. 7 Service de Réanimation médico-chirurgicale, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris, Bobigny, France. 8 Service de réanimation médico-chirurgicale, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes,  France; IAME, Université Paris Diderot, Paris, France. 9 Service de réanimation médicale, Hôpital Bicètre, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicètre, France. 10 Service de Réanimation Médicale et Pneumologie, Hôpital de La Pitié Salpétrière, Assistance Publique-Hôpitaux de Paris, Paris, France. 11 Service de Réanimation Médicale, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France. 12 Service de Réanimation, Centre hospitalier de Versailles, Le Chesnay, France. 13 Service de Réanimation, Centre hospitalier Intercommunal de Villeneuve Saint-Georges, Villeneuve Saint-Georges, France. 14 Service de Réanimation Médicale, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France.

 

Abstract

In a multicenter cohort study including 22 oseltamivir-treated patients with influenza A(H1N1)pdm09 acute respiratory distress syndrome, prevalence of the H275Y substitution in the neuraminidase, responsible for highly reduced sensitivity to oseltamivir, was 23%. Patients infected with the H275Y mutant virus had higher day-28 mortality than others (80% vs 12%; p=0.011).

© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

KEYWORDS: Influenza A Virus, H1N1 Subtype; Oseltamivir; Pneumonia, Viral; Respiratory Distress Syndrome, Adult

PMID: 31538643 DOI: 10.1093/cid/ciz904

Keywords: Seasonal Influenza; H1N1pdm09; Antivirals; Drugs Resistance; Oseltamivir; Pneumonia; ARDS; France.

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Bidirectional #Human-Swine #Transmission of Seasonal #Influenza A #H1N1pdm09 Virus in #Pig Herd, #France, 2018 (Emerg Infect Dis., abstract)

[Source: US Centers for Disease Control and Prevention (CDC), Emerging Infectious Diseases Journal, full page: (LINK). Abstract, edited.]

Volume 25, Number 10—October 2019 / Dispatch

Bidirectional Human-Swine Transmission of Seasonal Influenza A(H1N1)pdm09 Virus in Pig Herd, France, 2018

Amélie Chastagner1, Vincent Enouf1, David Peroz, Séverine Hervé, Pierrick Lucas, Stéphane Quéguiner, Stéphane Gorin, Véronique Beven, Sylvie Behillil, Philippe Leneveu, Emmanuel Garin, Yannick Blanchard, Sylvie van der Werf, and Gaëlle Simon

Author affiliations: French Agency for Food, Environmental and Occupational Health, and Safety, Ploufragan, France (A. Chastagner, S. Hervé, P. Lucas, S. Quéguiner, S. Gorin, V. Beven, Y. Blanchard, G. Simon); Institut Pasteur, Paris, France (V. Enouf, S. Behillil, S. van der Werf); Atlantic Vétérinaires, Ancenis, France (D. Peroz); CEVA Santé Animale SA, Libourne, France (P. Leneveu); Coop de France, Paris (E. Garin); Plateforme Epidémiosurveillance Santé Animale, Lyon, France (E. Garin)

 

Abstract

In 2018, a veterinarian became sick shortly after swabbing sows exhibiting respiratory syndrome on a farm in France. Epidemiologic data and genetic analyses revealed consecutive human-to-swine and swine-to-human influenza A(H1N1)pdm09 virus transmission, which occurred despite some biosecurity measures. Providing pig industry workers the annual influenza vaccine might reduce transmission risk.

Keywords: Seasonal Influenza; H1N1pdm09; Human; Pigs; France.

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Personalised #mechanical #ventilation tailored to #lung morphology versus low positive end-expiratory pressure for patients with #ARDS in #France (the LIVE study): a multicentre, single-blind, RCT (Lancet Resp Med., abstract)

[Source: Lancet Respiratory Medicine, full page: (LINK). Abstract, edited.]

Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial

Jean-Michel Constantin, MD, Matthieu Jabaudon, MD, Jean-Yves Lefrant, MD, Samir Jaber, MD, Jean-Pierre Quenot, MD, Olivier Langeron, MD, Martine Ferrandière, MD, Fabien Grelon, MD, Philippe Seguin, MD, Carole Ichai, MD, Benoit Veber, MD, Bertrand Souweine, MD, Thomas Uberti, MD, Sigismond Lasocki, MD, François Legay, MD, Marc Leone, MD, Nathanael Eisenmann, MD, Claire Dahyot-Fizelier, MD, Hervé Dupont, MD, Karim Asehnoune, MD, Achille Sossou, MD, Gérald Chanques, MD, Laurent Muller, MD, Jean-Etienne Bazin, MD, Antoine Monsel, MD, Lucile Borao, PhD, Jean-Marc Garcier, MD, Jean-Jacques Rouby, MD, Bruno Pereira, PhD, Emmanuel Futier, MD, for theAZUREA Network †

Published: August 06, 2019 / DOI: https://doi.org/10.1016/S2213-2600(19)30138-9

 

Summary

Background

The effect of personalised mechanical ventilation on clinical outcomes in patients with acute respiratory distress syndrome (ARDS) remains uncertain and needs to be evaluated. We aimed to test whether a mechanical ventilation strategy that was personalised to individual patients’ lung morphology would improve the survival of patients with ARDS when compared with standard of care.

Methods

We designed a multicentre, single-blind, stratified, parallel-group, randomised controlled trial enrolling patients with moderate-to-severe ARDS in 20 university or non-university intensive care units in France. Patients older than 18 years with early ARDS for less than 12 h were randomly assigned (1:1) to either the control group or the personalised group using a minimisation algorithm and stratified according to the study site, lung morphology, and duration of mechanical ventilation. Only the patients were masked to allocation. In the control group, patients received a tidal volume of 6 mL/kg per predicted bodyweight and positive end-expiratory pressure (PEEP) was selected according to a low PEEP and fraction of inspired oxygen table, and early prone position was encouraged. In the personalised group, the treatment approach was based on lung morphology; patients with focal ARDS received a tidal volume of 8 mL/kg, low PEEP, and prone position. Patients with non-focal ARDS received a tidal volume of 6 mL/kg, along with recruitment manoeuvres and high PEEP. The primary outcome was 90-day mortality as established by intention-to-treat analysis. This study is registered online with ClinicalTrials.gov, NCT02149589.

Findings

From June 12, 2014, to Feb 2, 2017, 420 patients were randomly assigned to treatment. 11 patients were excluded in the personalised group and nine patients were excluded in the control group; 196 patients in the personalised group and 204 in the control group were included in the analysis. In a multivariate analysis, there was no difference in 90-day mortality between the group treated with personalised ventilation and the control group in the intention-to-treat analysis (hazard ratio [HR] 1·01; 95% CI 0·61–1·66; p=0·98). However, misclassification of patients as having focal or non-focal ARDS by the investigators was observed in 85 (21%) of 400 patients. We found a significant interaction between misclassification and randomised group allocation with respect to the primary outcome (p<0·001). In the subgroup analysis, the 90-day mortality of the misclassified patients was higher in the personalised group (26 [65%] of 40 patients) than in the control group (18 [32%] of 57 patients; HR 2·8; 95% CI 1·5–5·1; p=0·012.

Interpretation

Personalisation of mechanical ventilation did not decrease mortality in patients with ARDS, possibly because of the misclassification of 21% of patients. A ventilator strategy misaligned with lung morphology substantially increases mortality. Whether improvement in ARDS phenotyping can decrease mortality should be assessed in a future clinical trial.

Funding

French Ministry of Health (Programme Hospitalier de Recherche Clinique InterRégional 2013).

Keywords: ARDS; Intensive Care; France.

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#Clinical #management of respiratory syndrome in #patients hospitalized for suspected #MERS #coronavirus #infection in the #Paris area from 2013 to 2016 (BMC Infect Dis., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

BMC Infect Dis. 2018 Jul 16;18(1):331. doi: 10.1186/s12879-018-3223-5.

Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from 2013 to 2016.

Bleibtreu A1,2,3,4, Jaureguiberry S5, Houhou N6, Boutolleau D7, Guillot H5, Vallois D8, Lucet JC9,10,11, Robert J12,13, Mourvillier B10,11,14, Delemazure J15, Jaspard M5, Lescure FX8,10,11, Rioux C8, Caumes E5, Yazdanapanah Y8,10,11.

Author information: 1 APHP, Hôpital Bichat Claude Bernard, Service des Maladies Infectieuses et Tropicales, Paris Diderot University, Paris, France. alexandre.bleibtreu@aphp.fr. 2 APHP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Service des Maladies Infectieuses et Tropicales, Paris, France. alexandre.bleibtreu@aphp.fr. 3 INSERM, IAME, UMR 1137, Paris, France. alexandre.bleibtreu@aphp.fr. 4 Univ Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, Paris, France. alexandre.bleibtreu@aphp.fr. 5 APHP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Service des Maladies Infectieuses et Tropicales, Paris, France. 6 Virology Department, APHP-Bichat-Claude Bernard Hospital, Paris, France. 7 AP-HP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Service de Virologie, et Sorbonne Universités, UPMC Univ Paris 06, CR7, CIMI, INSERM U1135, Paris, France. 8 APHP, Hôpital Bichat Claude Bernard, Service des Maladies Infectieuses et Tropicales, Paris Diderot University, Paris, France. 9 APHP, Infection control unit, Bichat Claude Bernard hospital, Paris Diderot University, Paris, France. 10 INSERM, IAME, UMR 1137, Paris, France. 11 Univ Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, Paris, France. 12 AP-HP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Bactériologie-Hygiène Hospitalière, Paris, France. 13 Faculté de Médecine P. & M. Curie Paris-6 – Site Pitié, Centre d’Immunologie et des Maladies Infectieuses (CIMI) – E13, Paris, France. 14 APHP- Hôpital Bichat Claude Bernard, Service de Réanimation médicale et Infectieuse, Paris, France. 15 Service de pneumologie et réanimation Département R3S, AP-HP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, unité de Soin de Réadaptation Post Réanimation (SRPR), Paris, France.

 

Abstract

BACKGROUND:

Patients with suspected Middle East respiratory syndrome coronavirus (MERS-CoV) infection should be hospitalized in isolation wards to avoid transmission. This suspicion can also lead to medical confusion and inappropriate management of acute respiratory syndrome due to causes other than MERS-CoV.

METHODS:

We studied the characteristics and outcome of patients hospitalized for suspected MERS-CoV infection in the isolation wards of two referral infectious disease departments in the Paris area between January 2013 and December 2016.

RESULTS:

Of 93 adult patients (49 male (52.6%), median age 63.4 years) hospitalized, 82 out of 93 adult patients had returned from Saudi Arabia, and 74 of them were pilgrims (Hajj). Chest X-ray findings were abnormal in 72 (77%) patients. The 93 patients were negative for MERS-CoV RT-PCR, and 70 (75.2%) patients had documented infection, 47 (50.5%) viral, 22 (23.6%) bacterial and one Plasmodium falciparum malaria. Microbiological analysis identified Rhinovirus (27.9%), Influenza virus (26.8%), Legionella pneumophila (7.5%), Streptococcus pneumoniae (7.5%), and non-MERS-coronavirus (6.4%). Antibiotics were initiated in 81 (87%) cases, with two antibiotics in 63 patients (67.7%). The median duration of hospitalization and isolation was 3 days (1-33) and 24 h (8-92), respectively. Time of isolation decreased over time (P < 0.01). Two patients (2%) died.

CONCLUSION:

The management of patients with possible MERS-CoV infection requires medical facilities with trained personnel, and rapid access to virological results. Empirical treatment with neuraminidase inhibitors and an association of antibiotics effective against S. pneumoniae and L. pneumophila are the cornerstones of the management of patients hospitalized for suspected MERS-CoV infection.

KEYWORDS: Isolation ward; Legionella; Middle East respiratory syndrome coronavirus (MERS-CoV); Pilgrims; Respiratory tract infection; Saudi Arabia

PMID: 30012113 PMCID: PMC6048819 DOI: 10.1186/s12879-018-3223-5 [Indexed for MEDLINE]  Free PMC Article

Keywords: MERS-CoV; France.

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