[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
Virology. 2019 Aug 22;537:172-185. doi: 10.1016/j.virol.2019.08.020. [Epub ahead of print]
Pathogenicity and genomic changes of a 2016 European H5N8 highly pathogenic avian influenza virus (clade 126.96.36.199) in experimentally infected mallards and chickens.
Leyson C1, Youk SS1, Smith D1, Dimitrov K1, Lee DH2, Larsen LE3, Swayne DE1, Pantin-Jackwood MJ4.
Author information: 1 Exotic and Emerging Avian Viral Diseases Unit, Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, Athens, GA, USA. 2 Department of Pathobiology & Veterinary Science, University of Connecticut, Storrs, Mansfield, CT, USA. 3 University of Copenhagen, Faculty of Health and Medical Sciences, Frederiksberg C, Denmark. 4 Exotic and Emerging Avian Viral Diseases Unit, Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, Athens, GA, USA. Electronic address: firstname.lastname@example.org.
Highly pathogenic avian influenza H5N8 clade 188.8.131.52 virus caused outbreaks in poultry and unusually high mortality in wild birds in 2016-2017. The pathobiology of one of these viruses was examined in mallards and chickens. High mortality and transmission to direct contacts were observed in mallards inoculated with medium and high doses of the virus. However, in chickens, high mortality occurred only when birds are given the high virus dose and no transmission was observed, indicating that the virus was better adapted to mallards. In comparison with the virus inoculum, viral sequences obtained from the chickens had a higher number of nucleotide changes but lower intra-host genomic diversity than viral sequences obtained from the mallards. These observations are consistent with population bottlenecks occurring when viruses infect and replicate in a host that it is not well adapted to. Whether these observations apply to influenza viruses in general remains to be determined.
Published by Elsevier Inc.
KEYWORDS: Adaptation; Chickens; Clade 184.108.40.206; Full genome sequencing; H5N8; Highly pathogenic avian influenza; Infectivity; Mallards; Pathogenicity; Transmission
PMID: 31493656 DOI: 10.1016/j.virol.2019.08.020
Keywords: Avian Influenza; H5N8; Animal models.