[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
Viruses. 2019 Jun 17;11(6). pii: E561. doi: 10.3390/v11060561.
Influenza A in Bovine Species: A Narrative Literature Review.
Sreenivasan CC1, Thomas M2, Kaushik RS3, Wang D4,5, Li F6,7.
Author information: 1 Department of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA. chithra.sreenivasan@sdstate.edu. 2 Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007, USA. milton.thomas@sdstate.edu. 3 Department of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA. radhey.kaushik@sdstate.edu. 4 Department of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA. dan.wang@sdstate.edu. 5 BioSystems Networks and Translational Research Center (BioSNTR), Brookings, SD 57007, USA. dan.wang@sdstate.edu. 6 Department of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA. feng.li@sdstate.edu. 7 BioSystems Networks and Translational Research Center (BioSNTR), Brookings, SD 57007, USA. feng.li@sdstate.edu.
Abstract
It is quite intriguing that bovines were largely unaffected by influenza A, even though most of the domesticated and wild animals/birds at the human-animal interface succumbed to infection over the past few decades. Influenza A occurs on a very infrequent basis in bovine species and hence bovines were not considered to be susceptible hosts for influenza until the emergence of influenza D. This review describes a multifaceted chronological review of literature on influenza in cattle which comprises mainly of the natural infections/outbreaks, experimental studies, and pathological and seroepidemiological aspects of influenza A that have occurred in the past. The review also sheds light on the bovine models used in vitro and in vivo for influenza-related studies over recent years. Despite a few natural cases in the mid-twentieth century and seroprevalence of human, swine, and avian influenza viruses in bovines, the evolution and host adaptation of influenza A virus (IAV) in this species suffered a serious hindrance until the novel influenza D virus (IDV) emerged recently in cattle across the world. Supposedly, certain bovine host factors, particularly some serum components and secretory proteins, were reported to have anti-influenza properties, which could be an attributing factor for the resilient nature of bovines to IAV. Further studies are needed to identify the host-specific factors contributing to the differential pathogenetic mechanisms and disease progression of IAV in bovines compared to other susceptible mammalian hosts.
KEYWORDS: Influenza A; MDBK cells; bovine; bovine cell cultures; bovine respiratory disease; bronchopneumonia; cattle outbreaks; epizootic cough; host restriction; ruminants; seroprevalence
PMID: 31213032 DOI: 10.3390/v11060561
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Keywords: Influenza A; Influenza D; Bovine.
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