Successful #treatment of #Pseudomonas aeruginosa infective #endocarditis via #haemodialysis outpatient parenteral antimicrobial therapy: case report (J Antimicrob Chemother., abstract)

[Source: Journal of Antimicrobial Chemotherapy, full page: (LINK). Abstract, edited.]

Successful treatment of Pseudomonas aeruginosainfective endocarditis via haemodialysis outpatient parenteral antimicrobial therapy: case report

Hector Maxwell-Scott, Rajeni Thangarajah, Amber Arnold, Paul Wade, John L Klein

Journal of Antimicrobial Chemotherapy, dkz096, https://doi.org/10.1093/jac/dkz096

Published: 04 March 2019

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Sir,

Pseudomonas aeruginosa infective endocarditis (IE) is rare and difficult to treat, often requiring long hospital admissions for intravenous antibiotics. Outpatient parenteral antimicrobial therapy (OPAT) is one option for the management of infection allowing for shorter inpatient stays. Certain antibiotics can be dosed for administration on haemodialysis, allowing for haemodialysis OPAT (HD-OPAT), but less is known about their pharmacokinetics and pharmacodynamics in this setting. Here we present a case of P. aeruginosa IE successfully treated with HD-OPAT using ceftazidime and oral ciprofloxacin.

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Keywords: Antibiotics; Pseudomonas aeruginosa; Endocarditis; Ceftazidime; Azithromycin.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.