[Source: Journal of Infectious Diseases, full page: (LINK). Abstract, edited.]
Common human coronaviruses seem at least as severe as influenza in patients hospitalized with acute respiratory infection: results from 8-year hospital-based surveillance in Quebec, Canada
Rodica Gilca, Sara Carazo, Rachid Amini, Hugues Charest, Gaston De Serres
The Journal of Infectious Diseases, jiaa477, https://doi.org/10.1093/infdis/jiaa477
Published: 06 August 2020
Few data exist about the role of common human coronaviruses (HCoV) in patients hospitalized for acute respiratory illness (ARI) and the severity of these infections compared to influenza.
Prospective data on virus etiology of ARI hospitalizations during the peaks of 8 influenza seasons (2011-12 to 2018-19) in Quebec, Canada, was used to compare patients with HCoV to those with influenza infections; generalized estimation equations models were used for multivariate analyses.
We identified 340 HCoV infections which affected 11.6%(n=136) of children and 5.2%(n=204) of adults hospitalized with ARI. The majority of children (75%) with HCoV infections were also coinfected with other respiratory viruses compared to 24% of the adults (p<0.0001). No deaths were recorded in children; 5.8% of adults with HCoV monoinfection compared to 4.2% of those with influenza monoinfection died (p=0.226). The risk of pneumonia was non-significantly lower in children with HCoV than with influenza but similarly high in adults. Markers of severity (length-of-stay, intensive-care admissions and case-fatality ratio) were comparable between these infections in multivariate analyses, both in children and adults.
In children and adults hospitalized with ARI, HCoV infections were less frequent than influenza infections, but HCoV monoinfections were as severe as influenza monoinfections.
common coronaviruses, influenza, respiratory hospitalization, children, adults, severity, case-fatality ratio, coinfections
Topic: influenza – coronavirus – adult – canada – child – inpatients – respiratory tract infections – infections – surveillance, medical – case fatality rate – quebec
Issue Section: Major Article
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Keywords: Coronavirus; Canada; Epidemiology.