guangdong – ETIDIoH

#Factors associated with #clinical #outcomes in patients with #Coronavirus Disease 2019 in #Guangzhou, #China (J Clin Virol., abstract)

[Source: Journal of Clinical Virology, full page: (LINK). Abstract, edited.]

Journal of Clinical Virology | Available online 14 October 2020, 104661 | In Press, Journal Pre-proof

Factors associated with clinical outcomes in patients with Coronavirus Disease 2019 in Guangzhou, China

Chunliang Lei 1, Weiyin Lin 1, Xilong Deng 1, Fengyu Hu 1, Fengjuan Chen, Weiping Cai, Yueping Li, Chunyan Wen, Yujuan Guan, JianWang, Xiaoting Chen, Yi Cao, Feng Li, Xiaoping Tang, Linghua Li, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510060, China

Received 19 August 2020, Accepted 10 October 2020, Available online 14 October 2020.

DOI: https://doi.org/10.1016/j.jcv.2020.104661

Highlights

We retrospectively included 297 hospitalized patients with COVID-19, and explore virological and immunological factors associated with clinical outcomes.
23.0 % (62/270) of COVID-19 patients were detectable for SARS-CoV-2 RNA in annal swabs and/or blood samples, higher in severe/critical cases than in mild/moderate cases (52.0 % vs. 16.4 %, P < 0.001). The CD4/CD8 ratio was higher in severe/critical cases than in mild/moderate cases (1.84 vs. 1.50, P = 0.022).
During a median follow-up period of 17 days, 36 (12.1 %) patients were admitted to intensive care unit (ICU), 16 (5.4 %) patients developed respiratory failure and underwent mechanical ventilation, four (1.3 %) patients needed extracorporeal membrane oxygenation (ECMO), one (0.34 %) patients died of multiple organ failure.
Detectable viral RNA in anal swabs and/or blood samples and higher CD4/CD8 ratio were independent risk factors of respiratory failure and ICU admission. Screening the extrapulmonary virus, close monitoring of lymphocyte subsets among COVID-19 patients are needed.

Abstract

Background

Coronavirus Disease 2019 (COVID-19) is threatening billions of people. We described the clinical characteristics and explore virological and immunological factors associated with clinical outcomes.

Methods

297 COVID-19 patients hospitalized in Guangzhou Eighth People’s Hospital between January 20 and February 20, 2020 were included. Epidemiological, clinical and laboratory data were collected and analyzed. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA in respiratory tract, blood samples and digestive tract was detected and lymphocyte subsets were tested periodically.

Result

Among the 297 patients (median age of 48 years), 154 (51.9 %) were female, 245 (82.5 %) mild/moderate cases, and 52 (17.5 %) severe/critical cases. 270 patients were detected for SARS-CoV-2 RNA in anal swabs and/or blood samples, and the overall positive rate was 23.0 % (62/270), higher in severe/critical cases than in mild/moderate cases (52.0 % vs. 16.4 %, P < 0.001). The CD4/CD8 ratio on admission was significantly higher in severe/critical cases than in mild/moderate cases (1.84 vs. 1.50, P = 0.022). During a median follow-up period of 17 days, 36 (12.1 %) patients were admitted to intensive care unit (ICU), 16 (5.4 %) patients developed respiratory failure and underwent mechanical ventilation, four (1.3 %) patients needed extracorporeal membrane oxygenation (ECMO), only one (0.34 %) patients died of multiple organ failure. Detectable SARS-CoV-2 RNA in anal swabs and/or blood samples, as well as higher CD4/CD8 ratio were independent risk factors of respiratory failure and ICU admission.

Conclusions

Most of COVID-19 patients in Guangzhou are mild/moderate, and presence of extrapulmonary virus and higher CD4/CD8 ratio are associated with higher risk of worse outcomes.

–

Keywords: SARS-CoV-2; COVID-19; Guangdong; China.

——

#Sewage as a Possible #Transmission #Vehicle During a #Coronavirus Disease 2019 #Outbreak in a Densely populated Community: #Guangzhou, #China, April 2020 (Clin Infect Dis., abstract)

[Source: Clinical Infectious Diseases, full page: (LINK). Abstract, edited.]

Sewage as a Possible Transmission Vehicle During a Coronavirus Disease 2019 Outbreak in a Densely populated Community: Guangzhou, China, April 2020

Jun Yuan, MD, Zongqiu Chen, MD, Chenghua Gong, B.Sc, Hui Liu, M.Sc, Baisheng Li, MD, Kuibiao Li, M.Sc, Xi Chen, MPH, Conghui Xu, B.Sc, Qinlong Jing, MD, Guocong Liu, B.Sc, Pengzhe Qin, B.Sc, Yufei Liu, B.Sc, Yi Zhong, B.Sc, Lijuan Huang, B.Sc, Bao-Ping Zhu, MD, PhD, Zhicong Yang, MD

Clinical Infectious Diseases, ciaa1494, https://doi.org/10.1093/cid/ciaa1494

Published: 12 October 2020

Abstract

Background

SARS-CoV-2 has been identified in the fecal matter of COVID-19 patients. However, sewage transmission has never been shown. In April 2020, a COVID-19 outbreak occurred in a densely populated community in Guangzhou, China. We investigated this outbreak to identify the mode of transmission.

Method

A home quarantined order was issued in the community. We collected throat swab samples from the residents and environmental samples from the surfaces inside and around the houses, and conducted RT-PCR testing and genome sequencing. We defined a case as a resident in this community with a positive RT-PCR test, with or without symptoms. We conducted a retrospective cohort study of all residents living in the same buildings as the cases to identify exposure risk factors.

Result

We found eight cases (four couples) in this community of 2888 residents (attack rate=2.8/1000), with onset during April 5–21, 2020. During their incubation periods, Cases 1-2 frequented market T with an ongoing outbreak. Cases 3-8 never visited market T during incubation period, lived in separate buildings from, and never interacted with, Cases 1-2. Retrospective cohort study showed that working as cleaners or waste picker (RR=13, 95% CIexact: 2.3-180), not changing to clean shoes after returning home (RR=7.4, 95% CIexact: 1.8-34), collating and cleaning dirty shoes after returning home (RR=6.3, 95% CIexact: 1.4-30) were significant exposure risk factors. Of 63 samples collected from street-sewage puddles and sewage-pipe surfaces, 19% tested positive for SARS-CoV-2. Of 50 environmental samples taken from cases’ apartments, 24% tested positive. Viral genome sequencing showed that the viruses identified from the squat toilet and shoe-bottom dirt inside the apartment of Cases 1-2 were homologous with those from Cases 3-8 and those identified from sewage samples. The sewage pipe leading from the apartment of Cases 1-2 to the drainage had a large hole above ground. Rainfalls after the onset of Cases 1-2 flooded the streets.

Conclusion

Our investigation has for the first time pointed to the possibility that SARS-CoV-2 might spread by sewage. This finding highlighted the importance of sewage management, especially in densely-populated places with poor hygiene and sanitation measures, such as urban slums and other low-income communities in developing countries.

COVID-19, SARS-CoV-2, disease outbreak, infectious disease transmission, epidemiology, risk factor, sewage management

Issue Section: Major Article

This content is only available as a PDF.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

–

Keywords: SARS-CoV-2; COVID-19; Environmental contamination; Guangdong; China.

——

Low #prevalence of #antibodies against #SARS‐CoV‐2 among voluntary #blood #donors in #Guangzhou, #China (J Med Virol., abstract)

[Source: Journal of Medical Virology, full page: (LINK). Abstract, edited.]

Low prevalence of antibodies against SARS‐CoV‐2 among voluntary blood donors in Guangzhou, China

Ru Xu, Jieting Huang, Chaohui Duan, Qiao Liao, Zhengang Shan, Min Wang, Xia Rong, Chengyao Li, Yongshui Fu, Hao Wang

First published: 19 August 2020 | DOI: https://doi.org/10.1002/jmv.26445

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/jmv.26445

ABSTRACT

Since the first case of COVID‐19 reported in late December of 2019 in Wuhan, China, the SARS‐CoV‐2 virus has caused approximately 20 million infections and 732 thousand deaths around the world by 11 August, 2020. Although the pathogen generally infects respiratory system, whether it is present in the bloodstream and whether it poses a threat to the blood supply during the period of outbreak is a serious public concern. In this study, we used ELISA to screen total antibodies against SARS‐CoV‐2 in 2,199 blood donors who had donated blood at the Guangzhou Blood Center during the epidemic. The Ig‐reactive samples were further characterized for IgA, IgG and IgM subtypes by ELISA and viral nucleic acid by real‐time PCR. Among the 2,199 plasma samples, seven were reactive under total antibodies screening. Further testing revealed that none of them had detectable viral nucleic acid or IgM antibody, but two samples contained IgA and IgG. The IgG antibody titers of both positive samples were 1:16 and 1:4, respectively. Our results indicated a low prevalence of past SARS‐CoV‐2 infection in our blood donors, as none of the tests were positive for viral nucleic acid and only 2/2,199 (0.09%) of samples were positive for IgG and IgA. There would be limited necessity of implementation of such testing in blood screening in COVID‐19 low‐risk area.

–

Keywords: SARS-CoV-2; COVID-19; Serology; Seroprevalence; Guangdong; China.

—–

The #evidence of #indirect #transmission of #SARS-CoV-2 reported in #Guangzhou, #China (BMC Pub Health, abstract)

[Source: BMC Public Health, full page: (LINK). Abstract, edited.]

The evidence of indirect transmission of SARS-CoV-2 reported in Guangzhou, China

Chaojun Xie, Hongjun Zhao, Kuibiao Li, Zhoubin Zhang, Xiaoxiao Lu, Huide Peng, Dahu Wang, Jin Chen, Xiao Zhang, Di Wu, Yuzhou Gu, Jun Yuan, Lin Zhang & Jiachun Lu

BMC Public Health volume 20, Article number: 1202 (2020)

Abstract

Background

More than 2 months have passed since the novel coronavirus disease 2019 (COVID-19) first emerged in Wuhan, China. With the migration of people, the epidemic has rapidly spread within China and throughout the world. Due to the severity of the epidemic, undiscovered transmission of COVID-19 deserves further investigation. The aim of our study hypothesized possible modes of SARS-CoV-2 transmission and how the virus may have spread between two family clusters within a residential building in Guangzhou, China.

Methods

In a cross-sectional study, we monitored and traced confirmed patients and their close contacts from January 11 to February 5, 2020 in Guangzhou, China, including 2 family cluster cases and 61 residents within one residential building. The environmental samples of the building and the throat swabs from the patients and from their related individuals were collected for SARS-CoV-2 and tested with real-time reverse transcriptase polymerase chain reaction (RT-PCR). The relevant information was collected and reported using big data tools.

Results

There were two notable family cluster cases in Guangzhou, which included 3 confirmed patients (family No.1: patient A, B, C) and 2 confirmed patients (family No.2: patient D, E), respectively. None of patients had contact with other confirmed patients before the onset of symptoms, and only patient A and patient B made a short stop in Wuhan by train. Home environment inspection results showed that the door handle of family No.1 was positive of SARS-CoV-2. The close contacts of the 5 patients all tested negative of SARS-CoV-2 and in good health, and therefore were released after the official medical observation period of 14-days. Finally, according to the traceability investigation through applying big data analysis, we found an epidemiological association between family No.1 and family No.2, in which patient D (family No.2) was infected through touching an elevator button contaminated by snot with virus from patient A (family No.1) on the same day.

Conclusions

Contaminants with virus from confirmed patients can pollute the environment of public places, and the virus can survive on the surface of objects for a short period of time. Therefore, in addition to the conventional droplet transmission, there is also indirect contact transmission such as snot-oral transmission that plays a crucial role in community spread of the virus.

–

Keywords: SARS-CoV-2; COVID-19; Guangdong; China; Epidemiology.

——

#Contact #Settings and #Risk for #Transmission in 3410 Close Contacts of Patients With #COVID19 in #Guangzhou, #China (Ann Intern Med., abstract)

[Source: Annals of Internal Medicine, full page: (LINK). Abstract, edited.]

Contact Settings and Risk for Transmission in 3410 Close Contacts of Patients With COVID-19 in Guangzhou, China – A Prospective Cohort Study

Lei Luo, PhD, Dan Liu, PhD, Xinlong Liao, MSc, Xianbo Wu, PhD, Qinlong Jing, PhD, Jiazhen Zheng, MSc, Fanghua Liu, PhD, Shigui Yang, PhD, Hua Bi, BSc, Zhihao Li, PhD, Jianping Liu, BSc, Weiqi Song, MSc, Wei Zhu, PhD, Zhenghe Wang, PhD, Xiru Zhang, PhD, Qingmei Huang, MSc, Peiliang Chen, PhD, Huamin Liu, PhD, Xin Cheng, MSc, Miaochun Cai, MSc, Pei Yang, MSc, Xingfen Yang, PhD, Zhigang Han, MSc, Jinling Tang, PhD, Yu Ma, MSc, Chen Mao, PhD

DOI: https://doi.org/10.7326/M20-2671

Abstract

Background:

Risk for transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to close contacts of infected persons has not been well estimated.

Objective:

To evaluate the risk for transmission of SARS-CoV-2 to close contacts in different settings.

Design:

Prospective cohort study.

Setting:

Close contacts of persons infected with SARS-CoV-2 in Guangzhou, China.

Participants:

3410 close contacts of 391 index cases were traced between 13 January and 6 March 2020. Data on the setting of the exposure, reverse transcriptase polymerase chain reaction testing, and clinical characteristics of index and secondary cases were collected.

Measurement:

Coronavirus disease 2019 (COVID-19) cases were confirmed by guidelines issued by China. Secondary attack rates in different settings were calculated.

Results:

Among 3410 close contacts, 127 (3.7% [95% CI, 3.1% to 4.4%]) were secondarily infected. Of these 127 persons, 8 (6.3% [CI, 2.1% to 10.5%]) were asymptomatic. Of the 119 symptomatic cases, 20 (16.8%) were defined as mild, 87 (73.1%) as moderate, and 12 (10.1%) as severe or critical. Compared with the household setting (10.3%), the secondary attack rate was lower for exposures in healthcare settings (1.0%; odds ratio [OR], 0.09 [CI, 0.04 to 0.20]) and on public transportation (0.1%; OR, 0.01 [CI, 0.00 to 0.08]). The secondary attack rate increased with the severity of index cases, from 0.3% (CI, 0.0 to 1.0%) for asymptomatic to 3.3% (CI, 1.8% to 4.8%) for mild, 5.6% (CI, 4.4% to 6.8%) for moderate, and 6.2% (CI, 3.2% to 9.1%) for severe or critical cases. Index cases with expectoration were associated with higher risk for secondary infection (13.6% vs. 3.0% for index cases without expectoration; OR, 4.81 [CI, 3.35 to 6.93]).

Limitation:

There was potential recall bias regarding symptom onset among patients with COVID-19, and the symptoms and severity of index cases were not assessed at the time of exposure to contacts.

Conclusion:

Household contact was the main setting for transmission of SARS-CoV-2, and the risk for transmission of SARS-CoV-2 among close contacts increased with the severity of index cases.

Primary Funding Source:

Guangdong Province Higher Vocational Colleges and Schools Pearl River Scholar Funded Scheme.

–

Keywords: SARS-CoV-2; COVID-19; Guangdong; China; Epidemiology.

——

A Confirmed Case of #SARS-CoV-2 Pneumonia with Routine RT – #PCR Negative and Virus #Variation in #Guangzhou, #China (Clin Infect Dis., abstract)

[Source: Clinical Infectious Diseases, full page: (LINK). Abstract, edited.]

A Confirmed Case of SARS-CoV-2 Pneumonia with Routine RT-PCR Negative and Virus Variation in Guangzhou, China

Zhengtu Li, Yinhu Li, Lingdan Chen, Shaoqiang Li, Le Yu, Airu Zhu, Feng Yang, Qian Jiang, Liyan Chen, Jincun Zhao, Wenju Lu, Nanshan Zhong, Feng Ye

Clinical Infectious Diseases, ciaa941, https://doi.org/10.1093/cid/ciaa941

Published: 09 July 2020

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia is a newly recognized disease, and its diagnosis is primarily confirmed by routine RT-PCR detection of SARS-CoV-2. However, we report a confirmed case of SARS-CoV-2 pneumonia with routine RT-PCR negative. This case has been finally diagnosed by Nanopore sequencing combined with antibody of SARS-CoV-2. Simultaneously, the ORF and NP gene variation of SARS-CoV-2 were found. This case has highlighted that false negative results could be present in the routine RT-PCR diagnosis, especially with virus variation. At the moment, Nanopore pathogen sequencing and antibody detection have been found effective in clinical diagnosis.

SARS-CoV-2, Pneumonia, Routine RT-PCR, Virus variation, Nanopore sequencing

Issue Section: Major Article

This content is only available as a PDF.

–

Keywords: SARS-CoV-2; COVID-19; Diagnostic tests.

——

#Household secondary #attack #rate of #COVID19 and associated #determinants in #Guangzhou, #China: a retrospective cohort study (Lancet Infect Dis., abstract)

[Source: Lancet Infectious Diseases, full page: (LINK). Abstract, edited.]

Household secondary attack rate of COVID-19 and associated determinants in Guangzhou, China: a retrospective cohort study

Qin-Long Jing, PhD †, Ming-Jin Liu, BS †, Zhou-Bin Zhang, MPH †, Li-Qun Fang, PhD †, Jun Yuan, MD †, An-Ran Zhang, BS, Natalie E Dean, BS, Lei Luo, PhD, Meng-Meng Ma, MD, Ira Longini, PhD, Eben Kenah, ScD, Ying Lu, MD, Yu Ma, MD, Neda Jalali, MS, Zhi-Cong Yang, MD, Yang Yang, PhD

Published: June 17, 2020 | DOI: https://doi.org/10.1016/S1473-3099(20)30471-0

Summary

Background

As of June 8, 2020, the global reported number of COVID-19 cases had reached more than 7 million with over 400 000 deaths. The household transmissibility of the causative pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains unclear. We aimed to estimate the secondary attack rate of SARS-CoV-2 among household and non-household close contacts in Guangzhou, China, using a statistical transmission model.

Methods

In this retrospective cohort study, we used a comprehensive contact tracing dataset from the Guangzhou Center for Disease Control and Prevention to estimate the secondary attack rate of COVID-19 (defined as the probability that an infected individual will transmit the disease to a susceptible individual) among household and non-household contacts, using a statistical transmission model. We considered two alternative definitions of household contacts in the analysis: individuals who were either family members or close relatives, such as parents and parents-in-law, regardless of residential address, and individuals living at the same address regardless of relationship. We assessed the demographic determinants of transmissibility and the infectivity of COVID-19 cases during their incubation period.

Findings

Between Jan 7, 2020, and Feb 18, 2020, we traced 195 unrelated close contact groups (215 primary cases, 134 secondary or tertiary cases, and 1964 uninfected close contacts). By identifying households from these groups, assuming a mean incubation period of 5 days, a maximum infectious period of 13 days, and no case isolation, the estimated secondary attack rate among household contacts was 12·4% (95% CI 9·8–15·4) when household contacts were defined on the basis of close relatives and 17·1% (13·3–21·8) when household contacts were defined on the basis of residential address. Compared with the oldest age group (≥60 years), the risk of household infection was lower in the youngest age group (<20 years; odds ratio [OR] 0·23 [95% CI 0·11–0·46]) and among adults aged 20–59 years (OR 0·64 [95% CI 0·43–0·97]). Our results suggest greater infectivity during the incubation period than during the symptomatic period, although differences were not statistically significant (OR 0·61 [95% CI 0·27–1·38]). The estimated local reproductive number (R) based on observed contact frequencies of primary cases was 0·5 (95% CI 0·41–0·62) in Guangzhou. The projected local R, had there been no isolation of cases or quarantine of their contacts, was 0·6 (95% CI 0·49–0·74) when household was defined on the basis of close relatives.

Interpretation

SARS-CoV-2 is more transmissible in households than SARS-CoV and Middle East respiratory syndrome coronavirus. Older individuals (aged ≥60 years) are the most susceptible to household transmission of SARS-CoV-2. In addition to case finding and isolation, timely tracing and quarantine of close contacts should be implemented to prevent onward transmission during the viral incubation period.

Funding

US National Institutes of Health, Science and Technology Plan Project of Guangzhou, Project for Key Medicine Discipline Construction of Guangzhou Municipality, Key Research and Development Program of China.

–

Keywords: SARS-CoV-2; COVID-19; Guangdong; China.

——

#Clinical characteristics of patients infected with the novel 2019 #coronavirus (#SARS-Cov-2) in #Guangzhou, #China (Open Forum Infect Dis., abstract)

[Source: Open Forum Infectious Diseases, full page: (LINK). Abstract, edited.]

Clinical characteristics of patients infected with the novel 2019 coronavirus (SARS-Cov-2) in Guangzhou, China

Yaping Wang, Baolin Liao, Yan Guo, Feng Li, Chunliang Lei, Fuchun Zhang, Weiping Cai, Wenxin Hong, Yu Zeng, Shuang Qiu, Jian Wang, Yueping Li, Xilong Deng, Jianping Li, Guangming Xiao, Fengxia Guo, Xunxi Lai, Zhiwei Liang, Xueliang Wen, Pinghong Li, Qian Jiao, Fangfei Xiang, Yong Wang, Chenghui Ma, Zhiwei Xie, Weiyin Lin, Yanrong Wu, Xiaoping Tang, Linghua Li, Yujuan Guan

Open Forum Infectious Diseases, ofaa187, https://doi.org/10.1093/ofid/ofaa187

Published: 19 May 2020

Abstract

Background

The clinical manifestations and factors associated with the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections outside of Wuhan are not clearly understood.

Methods

All laboratory-confirmed cases with SARS-Cov-2 infection hospitalized and monitored in Guangzhou Eighth People’s Hospital were recruited from 10 Jan to 20 Feb.

Results

A total of 275 patients were included in this study. The median patient age was 49 years, and 63.6% of them had exposure to Wuhan. The median virus incubation period was 6 days. Fever (70.5%) and dry cough (56.0%) were the most common symptoms. A decreased albumin level was found in 51.3% of patients, lymphopenia in 33.5%, and pneumonia based on chest computed tomography CT in 86%. Approximately 16% of patients (n = 45) had severe disease, and there were no deaths. Compared with patients with non-severe disease, those with severe disease were older, had a higher frequency of coexisting conditions and pneumonia, and had a shorter incubation period (all, P < 0.05). There were no differences between patients who likely contracted the virus in Wuhan, and those that had no exposure to Wuhan. Multivariate logistic regression analysis indicated that older age, male sex, and decreased albumin level were independently associated with disease severity.

Conclusions

The frequency of patients with a severe SARS-CoV-2 infection in Guangzhou, China, was lower than in Wuhan, China. Early diagnosis and treatment is important for controlling SARS-CoV-2 infections.

SARS-CoV-2, epidemiology, clinical characteristics, risk factors, viral load

Issue Section: Major Article

This content is only available as a PDF.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

–

Keywords: SARS-CoV-2; COVID-19; Guangdong; China.

——

Comments

Prolonged #Persistence of #SARS-CoV-2 #RNA in #Body #Fluids (Emerg Infect Dis., abstract)

[Source: US Centers for Disease Control and Prevention (CDC), Emerging Infectious Diseases Journal, full page: (LINK). Abstract, edited.]

Volume 26, Number 8—August 2020 | Dispatch

Prolonged Persistence of SARS-CoV-2 RNA in Body Fluids

Jiufeng Sun1, Jianpeng Xiao1, Ruilin Sun1, Xi Tang1, Chumin Liang, Huifang Lin, Lilian Zeng, Jianxiong Hu, Rinyu Yuan, Pingping Zhou, Jinju Peng, Qianlin Xiong, Fengfu Cui, Zhe Liu, Jing Lu, Junzhang Tian , Wenjun Ma, and Changwen Ke

Author affiliations: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China (J. Sun, J. Xiao, C. Liang, H. Lin, L. Zeng, J. Hu, R. Yuan, P. Zhou, J. Peng, Q. Xiong, F. Cui, Z. Liu, J. Lu, W. Ma, C. Ke); Guangdong Second Provincial General Hospital, Guangzhou (R. Sun, J. Tian); First People’s Hospital of Foshan, Foshan, China (X. Tang)

Abstract

We prospectively assessed 49 coronavirus disease cases in Guangdong, China, to estimate the frequency and duration of detectable severe acute respiratory syndrome coronavirus 2 RNA in human body fluids. The prolonged persistence of virus RNA in various body fluids may guide the clinical diagnosis and prevention of onward virus transmission.

–

Keywords: SARS-CoV-2; COVID-19; Guangdong; China.

——

#Shenzhen’ #experience on containing 2019 novel #coronavirus-infected pneumonia #transmission (QJM Int J Med., summary)

[Source: QJM International Journal of Medicine, full page: (LINK). Summary, edited.]

Shenzhen’ experience on containing 2019 novel coronavirus-infected pneumonia transmission

Y Fang, S Zhang, Zhijian Yu, H Wang, Q Deng

QJM: An International Journal of Medicine, hcaa112, https://doi.org/10.1093/qjmed/hcaa112

Published: 03 May 2020

Issue Section: Commentary

___

The first novel coronavirus (SARS-CoV-2)-infected pneumonia (NCIP) patient outside Hubei Province was found in Shenzhen on 16 January 2020. It was an imported case from Wuhan city.1 As the largest migrant city in China, there are 1 030 000 migrants from Hubei Province, with 110 000 from Wuhan.2 At present, the number of infected cases (416 cases) in Shenzhen ranks top three in China outside Hubei. However, before the outbreak of NCIP, Shenzhen municipal government and hospitals had proactively taken forceful measures, which prevented the disease transmission in a powerful way at an early stage. As of 20 February, Shenzhen has not seen locally newly confirmed cases. Our hospital—Huazhong University of Science and Technology Union Shenzhen Hospital has not received newly confirmed cases for 30 days till 11 March. Meantime, till now, no medical workers have been infected. However, when the epidemic in under control and the number of newly added patients is dropping dramatically in China, the number of affected countries has tripled. There are 118 000 cases in 114 countries and 4291 people have lost their lives. Many medical workers have been infected and died. WHO made the assessment that COVID-19 can be characterized as a pandemic on 11 March 2020. We think that the epidemic prevention and control in Shenzhen are encouraging is partly because we acted ahead of time and have done a lot of work as below, so we hope to share our experience and help countries to combat the epidemic.

(…)

–

Keywords: SARS-CoV-2; COVID-19; China.

—–

Share this:

Share this:

Share this:

Share this:

Share this:

Share this:

Share this:

Share this:

Share this:

Share this: