[Source: The New England Journal of Medicine, full page: (LINK). Summary, edited.]
Neurodevelopment in Infants Exposed to Zika Virus In Utero
December 13, 2018 / N Engl J Med 2018; 379:2377-2379 / DOI: 10.1056/NEJMc1800098
To the Editor:
During the Zika virus (ZIKV) epidemic in Rio de Janeiro from September 2015 through June 2016, a prospective cohort study involving symptomatic pregnant women who had ZIKV infection confirmed by reverse-transcriptase–polymerase-chain-reaction assay was established.1 The study was approved by the institutional review boards at Fundação Oswaldo Cruz in Rio de Janeiro and the University of California, Los Angeles, and all the women provided written informed consent for themselves and their children.
M. Elisabeth Lopes Moreira, M.D., Karin Nielsen-Saines, M.D., Patricia Brasil, M.D., Tara Kerin, Ph.D., Luana Damasceno, M.S., Marcos Pone, M.D., Liege M.A. Carvalho, M.D., Sheila M. Pone, M.D., Zilton Vasconcelos, Ph.D., Ieda P. Ribeiro, Ph.D., Andrea A. Zin, M.D., Irena Tsui, M.D., Kristina Adachi, M.D., Stephanie L. Gaw, M.D., Umme-Aiman Halai, M.D., Tania S. Salles, M.D., Denise C. da Cunha, M.D., Myrna C. Bonaldo, Ph.D., Claudia Raja Gabaglia, M.D., Leticia Guida, Ph.D., Jociele Malacarne, Ph.D., Roozemerie P. Costa, B.S., S. Clair Gomes, Jr., Ph.D., A. Beatriz Reis, M.S., Fernanda V.M. Soares, Ph.D., Renata H. Hasue, Ph.D., Carolina Y.P. Aizawa, M.S., Fernanda F. Genovesi, M.S., Mitsue Aibe, M.D., Christa Einspieler, Ph.D., Peter B. Marschik, Ph.D., J. Paulo Pereira, Jr., M.D., Elyzabeth A. Portari, M.D., Carla Janzen, M.D., James D. Cherry, M.D.
Supported by grants from the Departamento de Ciência e Tecnologia (DECIT) do Ministério da Saúde do Brasil (25000.072811/2016-17); Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) (88887.116627/2016-01); Brazilian National Council for Scientific and Technological Development (CNPq) (441098/2016-9); Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) (E_18/2015TXB); ZIKAlliance; the Thrasher Research Fund (20164370); the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) (AI28697 and AI1259534-01); the National Eye Institute of the NIH (AI129847-01); the Wellcome Trust and the United Kingdom Department for International Development (205377-Z16-Z); and the European Union Horizon 2020 research and innovation program (ZikaPLAN grant agreement no. 734584).
Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org.
Keywords: Zika Virus; Zika Congenital Syndrome.