[Source: Eurosurveillance, full page: (LINK). Abstract, edited.]
West Nile virus infection in individuals with pre-existing Usutu virus immunity, northern Italy, 2018
Alessandro Sinigaglia1, Monia Pacenti2, Thomas Martello1, Silvana Pagni1,2, Elisa Franchin1,2, Luisa Barzon1,2
Affiliations: 1 Department of Molecular Medicine, University of Padova, Padova, Italy; 2 Microbiology and Virology Unit, Padova University Hospital, Padova, Italy
Correspondence: Luisa Barzon
Citation style for this article: Sinigaglia Alessandro, Pacenti Monia, Martello Thomas, Pagni Silvana, Franchin Elisa, Barzon Luisa. West Nile virus infection in individuals with pre-existing Usutu virus immunity, northern Italy, 2018. Euro Surveill. 2019;24(21):pii=1900261. https://doi.org/10.2807/1560-7917.ES.2019.24.21.1900261
Received: 27 Apr 2019; Accepted: 22 May 2019
In 2018, there was a large West Nile virus (WNV) outbreak in northern Italy. We observed five atypical cases of WNV infection that were characterised by the presence of WNV RNA and WNV IgG at the time of diagnosis, but no IgM response during follow-up. Neutralisation assays demonstrated pre-existing Usutu virus immunity in all patients. Besides challenging diagnosis, the immunological crosstalk between the two viruses warrants further investigation on possible cross-protection or infection enhancement effects.
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Keywords: WNV; Usutu virus; ADE; Italy.