[Source: The Journal of Infectious Diseases, full page: (LINK). Summary, edited.]
Preparing for the Next Influenza Pandemic: The Development of a Universal Influenza Vaccine
Michelle C. Crank, John R. Mascola, Barney S. Graham*
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
*Correspondence: Barney S. Graham, MD, PhD; 40 Convent Dr. Bethesda, MD, 20892, Phone: 301 594-8468, Fax: 301-480-2771, Email: email@example.com
Funding Statement: This work was supported by intramural funding from the National Institute of Allergy and Infectious Diseases.
Conflict of Interest Statement: JRM and BSG are listed as inventors on patents related to influenza vaccines including E-094-2014 & E-060-2015 (BSG), E-061-2016 (JRM), and E-066-2014 & E-228-2016 (both).
Keywords: Influenza, Vaccine, Pandemic
Word count: 1723 (including references) / Accepted Manuscript
Published by Oxford University Press for the Infectious Diseases Society of America 2019. This work is written by (a) US Government employee(s) and is in the public domain in the US.
At the centenary of the 1918 influenza pandemic that took upwards of 100 million lives within one year, the world remains unprepared to prevent a similar catastrophic event from occurring. In addition, seasonal epidemic influenza continues to cause worldwide morbidity and mortality on a yearly basis, and current vaccines offer suboptimal protective immunity. In this collection of articlesb, we review the scientific opportunities for developing influenza vaccines with broad coverage, commonly referred to as “universal” influenza vaccines, that would better protect us against the global burden of seasonal epidemics and offer the potential to protect us from a 1918-like pandemic event.
Keywords: Influenza A; Pandemic Influenza; Spanish Flu; Vaccines.