[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
BMC Res Notes. 2019 Jun 10;12(1):326. doi: 10.1186/s13104-019-4371-4.
Serological evidence of Zika virus infection in febrile patients at Greater Accra Regional Hospital, Accra Ghana.
Ankrah GA1, Bonney JHK2, Agbosu EE3, Pratt D3, Adiku TK1,4.
Author information: 1 Department of Medical Microbiology, College of Health Sciences, University of Ghana, Korle Bu, Accra, Ghana. 2 Virology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P.O. Box LG 581, Legon, Accra, Ghana. Kbonney@noguchi.ug.edu.gh. 3 Virology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P.O. Box LG 581, Legon, Accra, Ghana. 4 Department of Biomedical Sciences, University of Health and Allied Sciences, Ho, Volta Region, Ghana.
Increase in the evidence of global occurrence of Zika viral infection suggests that in Africa the circulation of the virus which causes 80% of asymptomatic infection could be undetected and/or overlooked. We sought to serologically detect Zika virus infection in febrile patients at Greater Accra Regional Hospital, Ghana.
Of the 160 patient serum samples analyzed, 33 were found to have antibodies against Zika virus infection. Among the sero-positives 30 (91%) of the cases were anti-Zika virus IgM with the 21-30-year age group recording the highest number of 8 (26%) and 2 (7%) cases being the least for the 61 years and above age group. All sero-positive febrile patients developed at least one symptom consistent with Zika virus infection: 33 (100%) fever, 25 (76%) muscle pain, 24 (73%) joint pain, and conjunctivitis 2 (6%). Digestive symptoms recorded include 16 (49%) nausea, 12 (36%) vomiting and diarrhea 18 (55%). In addition, 28 (85%) loss of appetite, 14 (75%) rapid respiration and chest pain 15 (42%) were reported by seropositive febrile patients. Our data indicates exposure to Zika virus which suggests the possible circulation of the virus among febrile patients in Ghana with a sero-prevalence rate of 20.6%.
KEYWORDS: Anti-Zika virus immunoglobulins M and G (IgM and IgG) antibodies; Enzyme linked immunosorbent assay (ELISA); Seroprevalence; Zika virus
PMID: 31182146 DOI: 10.1186/s13104-019-4371-4
Keywords: Zika Virus; Serology; Seroprevalence; Ghana.