[Source: US Centers for Disease Control and Prevention (CDC), Emerging Infectious Diseases Journal, full page: (LINK). Abstract, edited.]
Volume 25, Number 10—October 2019 / Research
Risk Factors for Carbapenem-Resistant Pseudomonas aeruginosa, Zhejiang Province, China
Yan-Yan Hu, Jun-Min Cao, Qing Yang, Shi Chen, Huo-Yang Lv, Hong-Wei Zhou, Zuowei Wu, and Rong Zhang
Author affiliations: Zhejiang University, Hangzhou, China (Y.-Y. Hu, Q. Yang, H.-W. Zhou, R. Zhang); Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou (J.-M. Cao, H.-Y. Lv); Hangzhou Third People’s Hospital, Hangzhou (S. Chen); Iowa State University, Ames, Iowa, USA (Z. Wu)
Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a public health concern worldwide, but comprehensive analysis of risk factors for CRPA remains limited in China. We conducted a retrospective observational study of carbapenem resistance in 71,880 P. aeruginosa isolates collected in Zhejiang Province during 2015–2017. We analyzed risk factors for CRPA, including the type of clinical specimen; the year, season, and region, in which it was collected; patient information, including age, whether they were an outpatient or inpatient, and whether inpatients were in the intensive care unit or general ward; and the level of hospital submitting isolates. We found CRPA was more prevalent among isolates from patients >60 years of age and in inpatients, especially in intensive care units. In addition, specimen types and seasons in which they were collected were associated with higher rates of CRPA. Our findings can help hospitals reduce the spread of P. aeruginosa and optimize antimicrobial drug use.
Keywords: Antibiotics; Drugs Resistance; Carbapenem; Pseudomonas aeruginosa; Zhejiang; China.