[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
Int J Infect Dis. 2019 Dec 19. pii: S1201-9712(19)30495-3. doi: 10.1016/j.ijid.2019.12.022. [Epub ahead of print]
Delayed-onset paraparesis in Lassa fever: A case report.
Duvignaud A1, Doutchi M2, Abejegah C3, Etafo I4, Jaspard M5, Serra B6, Tricaud E7, Levy-Marchal C8, Anglaret X9, Ahmed LA10, Adedosu AN11, Malvy D12, Ayodeji OO13.
Author information: 1 Inserm U1219, University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, France; Department of Infectious Diseases and Tropical Medicine, Division of Tropical Medicine and Clinical International Health, CHU de Bordeaux, Hôpital Pellegrin, Place Amélie Raba Léon, 33076 Bordeaux, France; Programme PAC-CI/ANRS Research Site, CHU de Treichville, 18 BP 1954 Abidjan 18, Abidjan, Côte d’Ivoire. Electronic address: alex.duvignaud@gmail.com. 2 The Alliance for International Medical Action, Route de l’Aéroport, Rue NG 96 BP: 15530, Dakar, Senegal; Department of Infectious Diseases, Centre Hospitalier National de Zinder, Zinder, Niger. Electronic address: m.doutchi@yahoo.fr. 3 Infection Control and Research Centre, Community Health Department, Federal Medical Centre Owo, Michael Adekun Ajasin Road, PMB 1053, Owo, Ondo State, Nigeria. Electronic address: cabejegah2007@gmail.com. 4 Infection Control and Research Centre, Community Health Department, Federal Medical Centre Owo, Michael Adekun Ajasin Road, PMB 1053, Owo, Ondo State, Nigeria. Electronic address: eziunorijeoma2014@yahoo.com. 5 Inserm U1219, University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, France; Programme PAC-CI/ANRS Research Site, CHU de Treichville, 18 BP 1954 Abidjan 18, Abidjan, Côte d’Ivoire; The Alliance for International Medical Action, Route de l’Aéroport, Rue NG 96 BP: 15530, Dakar, Senegal. Electronic address: marie.jaspard@coral.alima.ngo. 6 Inserm U1219, University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, France; Programme PAC-CI/ANRS Research Site, CHU de Treichville, 18 BP 1954 Abidjan 18, Abidjan, Côte d’Ivoire; The Alliance for International Medical Action, Route de l’Aéroport, Rue NG 96 BP: 15530, Dakar, Senegal. Electronic address: beatrice.serra33@gmail.com. 7 Imagerie médicale du 109, Rue de Messei, Flers, France. Electronic address: elise.tricaud@gmail.com. 8 The Alliance for International Medical Action, Route de l’Aéroport, Rue NG 96 BP: 15530, Dakar, Senegal. Electronic address: claire.levy-marchal@coral.alima.ngo. 9 Inserm U1219, University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, France; Programme PAC-CI/ANRS Research Site, CHU de Treichville, 18 BP 1954 Abidjan 18, Abidjan, Côte d’Ivoire. Electronic address: Xavier.Anglaret@u-bordeaux.fr. 10 Department of Family Medicine, Federal Medical Centre Owo, Michael Adekun Ajasin Road, PMB 1053, Owo, Ondo State, Nigeria. Electronic address: akahmed2@yahoo.co.uk. 11 Viral Hemorrhagic Fever Laboratory, Federal Medical Centre Owo, Michael Adekun Ajasin Road, PMB 1053, Owo, Ondo State, Nigeria. Electronic address: nelsonadedosu@gmail.com. 12 Inserm U1219, University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, France; Department of Infectious Diseases and Tropical Medicine, Division of Tropical Medicine and Clinical International Health, CHU de Bordeaux, Hôpital Pellegrin, Place Amélie Raba Léon, 33076 Bordeaux, France; Programme PAC-CI/ANRS Research Site, CHU de Treichville, 18 BP 1954 Abidjan 18, Abidjan, Côte d’Ivoire. Electronic address: denis.malvy@chu-bordeaux.fr. 13 Infection Control and Research Centre, Community Health Department, Federal Medical Centre Owo, Michael Adekun Ajasin Road, PMB 1053, Owo, Ondo State, Nigeria. Electronic address: femiayodeji@yahoo.com.
Abstract
Lassa fever (LF) is an endemic viral hemorrhagic fever in West Africa. Among the serious complications of the disease are neurological manifestations whose spectrum is incompletely known. Here we report the case of a 61-year-old man who developed a delayed-onset paraparesis a few weeks after getting infected with Lassa virus thereby suggesting a possible association between LF and spinal cord disorders.
Copyright © 2019. Published by Elsevier Ltd.
KEYWORDS: Acute Kidney Injury; Central Nervous System; Lassa fever; Myelitis; Nigeria; Paraparesis
PMID: 31866549 DOI: 10.1016/j.ijid.2019.12.022
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Keywords: Lassa fever; Paraparesis; Neurology.
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