[Source: Journal of Antimicrobial Chemotherapy, full page: (LINK). Abstract, edited.]
A novel plasmid-mediated polymyxin resistance determinant (mcr-1.8) in Escherichia coli recovered from broiler chickens in Brunei Darussalam
Muhd Haziq F Abdul Momin, Apostolos Liakopoulos, David C Bean, Lynette M Phee,David W Wareham
Journal of Antimicrobial Chemotherapy, dkz352, https://doi.org/10.1093/jac/dkz352
Published: 23 August 2019
Issue Section: Research letter
MDR Gram-negative bacteria are identified as critical pathogens and their effective treatment increasingly relies on the polymyxins (polymyxin B, colistin), either alone or as part of unorthodox combination therapies.1 The rapid emergence of polymyxin resistance due to mutations/insertions in genes involved in LPS modifications (lpxCAD, pmrA/B, mgrB, phoP/Q, ccrAB) has been reported among individuals exposed to or treated with polymyxins.1 Of greater concern are increasing reports of resistance due to the acquisition of phosphoethanolamine (PEtN) transferases, enzymes that catalyse the addition of phosphoethanolamine to lipid A, resulting in lower binding affinity of polymyxins.1
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Keywords: Antibiotics; Drugs Resistance; MCR1; Polymyxins; Poultry; Brunei.