[Source: F1000 Research, full page: (LINK). Abstract, edited.]
Recent advances in marburgvirus research [version 1; peer review: 3 approved]
Judith Olejnik 1,2, Elke Mühlberger 1,2, Adam J. Hume 1,2
Author details: 1 Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, 02118, USA; 2 National Emerging Infectious Diseases Laboratories, Boston University, Boston, Massachusetts, 02118, USA
Marburgviruses are closely related to ebolaviruses and cause a devastating disease in humans. In 2012, we published a comprehensive review of the first 45 years of research on marburgviruses and the disease they cause, ranging from molecular biology to ecology. Spurred in part by the deadly Ebola virus outbreak in West Africa in 2013–2016, research on all filoviruses has intensified. Not meant as an introduction to marburgviruses, this article instead provides a synopsis of recent progress in marburgvirus research with a particular focus on molecular biology, advances in animal modeling, and the use of Egyptian fruit bats in infection experiments.
Keywords: Marburg virus, marburgviruses, filovirus, filoviruses, Egyptian rousette, viral proteins
Corresponding author: Adam J. Hume
Competing interests: No competing interests were disclosed.
Grant information: This work was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under award numbers R01-AI133486 and R21-AI135912.
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Copyright: © 2019 Olejnik J et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
How to cite: Olejnik J, Mühlberger E and Hume AJ. Recent advances in marburgvirus research [version 1; peer review: 3 approved]. F1000Research 2019, 8(F1000 Faculty Rev):704 (https://doi.org/10.12688/f1000research.17573.1)
First published: 21 May 2019, 8(F1000 Faculty Rev):704 (https://doi.org/10.12688/f1000research.17573.1)
Latest published: 21 May 2019, 8(F1000 Faculty Rev):704 (https://doi.org/10.12688/f1000research.17573.1)
Keywords: Filovirus; Marburg virus.