[Source: PLoS One, full page: (LINK). Abstract, edited.]
OPEN ACCESS / PEER-REVIEWED / RESEARCH ARTICLE
Seroprevalence of human T-lymphotropic virus HTLV and its associated factors in donors of a blood bank of Medellín-Colombia, 2014-2018
Jaiberth Antonio Cardona-Arias, Carolina Vélez-Quintero , Olga Victoria Calle-González , Jennifer Florez-Duque, Juan Carlos Zapata
Published: August 12, 2019 / DOI: https://doi.org/10.1371/journal.pone.0221060
Research on HTLV in Colombia is limited; despite being an endemic country there are few studies on the magnitude of this infection. The aim of this study was to determine the seroprevalence of HTLV I/II and its associated factors in donors to a blood bank of Medellín Colombia, 2014–2018.
This is a cross-sectional study of 52,159 donors with a secondary information source. Seroprevalence of HTLV I/II was determined with its confidence interval and the population characteristics were described by frequency and summary measures. To explore the associated factors, Pearson’s Chi square test, Mann-Whitney U test, crude odds ratios were used and they were adjusted by logistic regression in SPSS 25.0.
88% of the population lived in the metropolitan area, 68.5% belonged to the University. 76.2% were altruistic donors (unpaid donors who did not donate to a specific patient). 24.5% were repetitive (paid) donors. 75% of the donors were under 41 years old. The seroprevalence of HTLV I/II was 0.176% (95% CI = 0.139% -0.213%), being statistically lower in repetitive donors and men.
The seroprevalence of HTLV I/II infection in the studied blood bank is lower than that reported in other blood banks at the departmental and national levels. In Medellín, it was associated with the frequency of donation and gender, which is useful information for the hemovigilance programs of the city.
Citation: Cardona-Arias JA, Vélez-Quintero C, Calle-González OV, Florez-Duque J, Zapata JC (2019) Seroprevalence of human T-lymphotropic virus HTLV and its associated factors in donors of a blood bank of Medellín-Colombia, 2014-2018. PLoS ONE 14(8): e0221060. https://doi.org/10.1371/journal.pone.0221060
Editor: Jason Blackard, University of Cincinnati College of Medicine, UNITED STATES
Received: April 11, 2019; Accepted: July 29, 2019; Published: August 12, 2019
Copyright: © 2019 Cardona-Arias et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: All relevant data are within the manuscript and its Supporting Information files.
Funding: This research relies upon salary support for the authors. JAC-A was supported by University of Antioquia and Cooperative University of Colombia. CV-Q, OVC-G, and JF-D were supported, as students, by the University of Antioquia. JCZ salary was supported by the Institute of Human Virology (IHV), University of Maryland School of Medicine. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Keywords: HTLV-I/II; Seroprevalence; Blood safety; Colombia.