[Source: US Centers for Disease Control and Prevention (CDC), Emerging Infectious Diseases Journal, full page: (LINK). Abstract, edited.]
Volume 25, Number 12—December 2019 / Research
Avian Influenza A Viruses among Occupationally Exposed Populations, China, 2014–2016
Chuansong Quan1, Qianli Wang1, Jie Zhang, Min Zhao, Qigang Dai, Ting Huang, Zewu Zhang, Shenghua Mao, Yifei Nie, Jun Liu, Yun Xie, Baorong Zhang, Yuhai Bi, Weifeng Shi, Peipei Liu, Dayan Wang, Luzhao Feng, Hongjie Yu, William J. Liu , and George F. Gao
Author affiliations: Chinese Center for Disease Control and Prevention, Beijing, China (C. Quan, J. Zhang, P. Liu, D. Wang, L. Feng, W.J. Liu, G.F. Gao); Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China (C. Quan, W. Shi); Fudan University, Shanghai, China (Q. Wang, H. Yu); Chinese Academy of Sciences, Beijing (M. Zhao, Y. Bi, G.F. Gao); Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China (Q. Dai); Sichuan Provincial Center for Disease Prevention and Control, Chengdu, China (T. Huang); Dongguan Municipal Center for Disease Control and Prevention, Dongguan, China (Z. Zhang); Shanghai Municipal Center for Disease Control and Prevention, Shanghai (S. Mao); Henan Provincial Center for Disease Control and Prevention, Zhengzhou, China (Y. Nie); Zaozhuang Center for Disease Control and Prevention, Zaozhuang, China (J. Liu); Jiangxi Provincial Center for Disease Control and Prevention, Nanchang, China (Y. Xie); Aviation General Hospital, Beijing (B. Zhang)
To determine the seroprevalence and seroconversion of avian influenza virus (AIV) antibodies in poultry workers, we conducted a seroepidemiologic study in 7 areas of China during December 2014–April 2016. We used viral isolation and reverse transcription PCR to detect AIVs in specimens from live poultry markets. We analyzed 2,124 serum samples obtained from 1,407 poultry workers by using hemagglutination inhibition and microneutralization assays. We noted seroprevalence of AIV antibodies for subtypes H9N2, H7N9, H6N1, H5N1-SC29, H5N6, H5N1-SH199, and H6N6. In serum from participants with longitudinal samples, we noted seroconversion, with >4-fold rise in titers, for H9N2, H7N9, H6N1, H5N1-SC29, H6N6, H5N6, and H5N1-SH199 subtypes. We found no evidence of H10N8 subtype. The distribution of AIV antibodies provided evidence of asymptomatic infection. We correlated AIV antibody prevalence in live poultry markets with increased risk for H7N9 and H9N2 infection among poultry workers.
Keywords: Avian Influenza; Human; China; Serology; Seroprevalence; H5N1; H5N6; H6N1; H6N6; H7N9; H9N2; Live poultry Markets.