New #influenza A(#H7N7) viruses detected in live #poultry #markets in #China (Virology, abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Virology. 2016 Sep 20;499:165-169. doi: 10.1016/j.virol.2016.06.015. [Epub ahead of print]

New influenza A(H7N7) viruses detected in live poultry markets in China.

Cui P1, Deng G2, Shi J3, Kong H3, Liu L3, Guan Y3, Suzuki Y4, Chen H5.

Author information: 1College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China. 2State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China. Electronic address: dengguohua@caas.cn. 3State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
4College of Life and Health Sciences, Chubu University, Aichi, Japan. 5College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China. Electronic address: chenhualan@caas.cn.

 

Abstract

H7N7 avian influenza viruses have been widely detected in wild birds and domestic poultry since they were first detected in chickens in Italy in 1902. They can occasionally transmit to humans. Here, we isolated six H7N7 viruses in live poultry markets during routine surveillance from 2010 to 2013. Sequences analysis revealed that these viruses are reassortants bearing genes of H3N8, H7N3, H7N7, and H10N7 influenza viruses detected in wild birds and ducks, and can be categorized into three genotypes (A, B, and C). All six viruses bound to both human-type and avian-type receptors. The viruses in genotype B and C could replicate efficiently in the lungs and nasal turbinates of mice without prior adaptation, and the genotype C virus also replicated in the brain of two of three mice tested. It is important to continue to monitor the evolution of H7N7 viruses and to evaluate their potential to cause human infections.

Copyright © 2016 Elsevier Inc. All rights reserved.

KEYWORDS: Avian influenza virus; H7N7; Live poultry market

PMID: 27661735 DOI: 10.1016/j.virol.2016.06.015

[PubMed – as supplied by publisher]

Keywords: Research; Abstracts; China; Poultry; Avian Influenza; H7N7; Reassortant Strain; H3N8; H7N3; H10N7.

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Co-circulation of #H5N6, #H3N2, #H3N8, and Emergence of Novel #Reassortant #H3N6 in a Local #Community in #Hunan Province in #China (Sci Rep., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Sci Rep. 2016 May 6;6:25549. doi: 10.1038/srep25549.

Co-circulation of H5N6, H3N2, H3N8, and Emergence of Novel Reassortant H3N6 in a Local Community in Hunan Province in China.

Li X1, Yang J1, Liu B1, Jia Y1, Guo J1, Gao X1, Weng S1, Yang M1, Wang L1, Wang LF2, Cui J3,2, Chen H4, Zhu Q1.

Author information: 1State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, CAAS, 1 Xujiaping, Lanzhou 730046, China. 2Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857. 3Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China. 4State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, 427 Maduan Street, Harbin 150001, China.

 

Abstract

Multiple infections of avian influenza viruses (AIVs) in poultry or wild birds contribute to the continued evolution of H5 subtype viruses in nature and provide potential recombination of AIVs of different origins. In this study, we carried out surveillance of AIVs in ducks, geese and the environment of a community in Hunan province, China, from 2014-2015. We isolated multiple co-circulated AIVs including H3N2, H3N8, and H5N6, and, most importantly, a novel reassortant: H3N6. Phylogenetic analyses suggest that H3N6 is highly likely derived from H5N6, which has recently been shown to have zoonotic potential with human infections. Studies with mammalian cell lines and a mouse model indicate that four selected AIVs of duck or goose origin can infect MDCK and A549 cells but have low pathogenicity in mice. We propose that a potential co-circulation of multiple subtypes including H5N6 in local area may result in the production of novel subtypes such as H3N6 by gene reassortment.

PMID: 27151540 [PubMed – in process]

Keywords: Research; Abstracts; Avian Influenza; H3N2; H3N8; H5N6; H3N6.

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New England harbor #seal #H3N8 #influenza #virus retains #avian-like #receptor specificity (Sci Rep., abstract)

[Source: Scientific Reports, full page: (LINK). Abstract, edited.]

Article | Open

New England harbor seal H3N8 influenza virus retains avian-like receptor specificity [      ]

Islam T. M. Hussein, Florian Krammer, Eric Ma, Michael Estrin, Karthik Viswanathan, Nathan W. Stebbins, Devin S. Quinlan, Ram Sasisekharan […] & Jonathan Runstadler

Scientific Reports 6, Article number: 21428 (2016) / doi:10.1038/srep21428

Received: 30 May 2015 – Accepted: 25 January 2016 – Published online: 18 February 2016

 

Abstract

An influenza H3N8 virus, carrying mammalian adaptation mutations, was isolated from New England harbor seals in 2011. We sought to assess the risk of its human transmissibility using two complementary approaches. First, we tested the binding of recombinant hemagglutinin (HA) proteins of seal H3N8 and human-adapted H3N2 viruses to respiratory tissues of humans and ferrets. For human tissues, we observed strong tendency of the seal H3 to bind to lung alveoli, which was in direct contrast to the human-adapted H3 that bound mainly to the trachea. This staining pattern was also consistent in ferrets, the primary animal model for human influenza pathogenesis. Second, we compared the binding of the recombinant HAs to a library of 610 glycans. In contrast to the human H3, which bound almost exclusively to α-2,6 sialylated glycans, the seal H3 bound preferentially to α-2,3 sialylated glycans. Additionally, the seal H3N8 virus replicated in human lung carcinoma cells. Our data suggest that the seal H3N8 virus has retained its avian-like receptor binding specificity, but could potentially establish infection in human lungs.

Keywords: Research; Abstracts; Avian Influenza; H3N8.

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#USA, #Canine #Flu Has #Dog Owners Wondering if Fido Needs a #Vaccine (NYT, Dec. 12 ‘15)

[Source: The New York Times, full page: (LINK).]

Canine Flu Has Dog Owners Wondering if Fido Needs a Vaccine [      ]

by JAN HOFFMAN 

A vaccine is conditionally approved for H3N2, which showed up in 25 states. But veterinarians are not recommending the vaccine for every dog.

(…)

Keywords: USA; Dogs; Canine Avian Influenza; A/H3N2; A/H3N8.

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