#Bibliometric analysis of #global #Lassa fever #research (1970-2017): a 47 – year study (BMC Infect Dis., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

BMC Infect Dis. 2018 Dec 10;18(1):639. doi: 10.1186/s12879-018-3526-6.

Bibliometric analysis of global Lassa fever research (1970-2017): a 47 – year study.

Okoroiwu HU1, López-Muñoz F2,3,4,5, Povedano-Montero FJ2,6.

Author information: 1 Haematology Unit, Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria. okoroiwuhenshaw@gmail.com. 2 Faculty of Health Sciences, University Camilo José Cela, Madrid, Spain. 3 Neuropsychopharmacology Unit, Hospital 12 de Octubre Research Institute (i+12), Madrid, Spain. 4 Portucalense Institute of Neuropsychology and Cognitive and Behavioural Neurosciences (INPP), Portucalense University, Porto, Portugal. 5 Thematic Network for Cooperative Health Research (RETICS), Addictive Disorders Network, Health Institute Carlos III, MICINN and FEDER, Madrid, Spain. 6 Faculty of Biomedical Sciences and Health, European University of Madrid, Madrid, Spain.




Lassa fever has been a public health concern in the West African sub-region where it is endemic and a latent threat to the world at large. We investigated the trend in Lassa fever research using bibliometric approach.


We used the SCOPUS database employing “Lassa fever” as search descriptor. The most common bibliometric indicators were applied for the selected publications.


The number of scientific research articles retrieved for Lassa fever research from 1970 to 2017 was 1101. The growth of publications was more linear (r = 0.67) than exponential (r = 0.53). The duplication time of the scientific articles was 9.19 years. Small number of authors were responsible for bulk of the article production (transience index of 78.89%). The collaboration index was 4.59 per paper. The Bradford core consisted of 19 journals in which Journal of Virology was at the top (4.6%). Majority of the output were from USA government agencies. United States was the most productive country. Joseph B. McCormick was the most productive author, while New England Journal of Medicine published the two most cited articles.


The growth of scientific Literature on Lassa fever was of linear pattern with high transient authors indicating low productivity and non-specialized authors from other related areas publishing sporadically. This study provides a helpful reference for medical virologists, epidemiologist, policy decision makers, academics and Lassa fever researchers.

KEYWORDS: Bibliometric analysis; Lassa; Lassa fever; Lassa research

PMID: 30526510 PMCID: PMC6288929 DOI: 10.1186/s12879-018-3526-6 Free PMC Article

Keywords: Lassa fever.



#Child #Influenza #Vaccination and #Adult #Work Loss: Reduced Sick Leave Use Only in Adults With Paid Sick Leave (Am J Prev Med., abstract)

[Source: American Journal of Preventive Medicine, full page: (LINK). Abstract, edited.]

Child Influenza Vaccination and Adult Work Loss: Reduced Sick Leave Use Only in Adults With Paid Sick Leave

William K. Bleser, PhD, MSPH, , Patricia Y. Miranda, PhD, MPH, Daniel A. Salmon, PhD, MPH

DOI: https://doi.org/10.1016/j.amepre.2018.09.013

Published online: December 17, 2018




Children are a population of interest for influenza. They are at increased risk for severe influenza, comprise a substantial portion of influenza morbidity, and significantly contribute to its transmission in the household and subsequent parental work loss. The association between influenza vaccination and work loss prevention, however, has rarely been studied, and the sparse existing literature has very limited generalizability to U.S. adults, thus requiring better characterization.


Using pooled National Health Interview Survey data (2013–2015, analyses conducted in 2018) nationally representative of working U.S. adults with household children (n=23,014), zero-inflated negative binomial regression examined the association of child influenza vaccination (exposure) with sick days (outcome) stratified by paid sick leave (no: n=10,741, yes: n=12,273).


Child influenza vaccination was associated with significantly lower sick day usage, but only among adults with paid sick leave (prevalence rate ratio=0.79, 95% CI=0.67, 0.93), equating to average annual sick days of 4.07 vs 3.29 in adults with unvaccinated versus vaccinated household children (difference=0.78 fewer days annually).


Influenza vaccination of children is associated with reduced sick leave in household adults, helping to keep the workforce healthy and reduce influenza’s costly annual economic burden. This only occurred among adults with paid sick leave, however, which is distributed inequitably by income, education, gender, occupation, and race/ethnicity. Health in All Policies considers downstream health effects of social and economic policy; the failure of federal policy to ensure paid sick leave likely contributes to propagating influenza and health inequities.

© 2018 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

Keywords: Seasonal Influenza; USA; Vaccines; Society; Poverty; Public Health.


Sleep and His Half Brother Death, John William Waterhouse (1874)



Sleep and His Half Brother Death
John William Waterhouse
Date: 1874
Style: Romanticism
Genre: mythological painting
Media: oil, canvas
Tag: Greek-and-Roman-Mythology, gods-and-goddesses, Hypnos, Thanatos,angels-and-archangels
Location: Private Collection
Dimensions: 69.85 x 90.81 cm


Permissions: Public domain.

Source: WikiArt, full page: https://www.wikiart.org/en/john-william-waterhouse/sleep-and-his-half-brother-death-1874


#Evidence of H1N1pdm09 #influenza exposure in #dogs and #cats, #Thailand: A serological survey (Zoonoses Public Health, abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Zoonoses Public Health. 2018 Dec 14. doi: 10.1111/zph.12551. [Epub ahead of print]

Evidence of pandemic H1N1 influenza exposure in dogs and cats, Thailand: A serological survey.

Tangwangvivat R1,2, Chanvatik S1,2, Charoenkul K1,2, Chaiyawong S1,2, Janethanakit T1,2, Tuanudom R1,3, Prakairungnamthip D1,3, Boonyapisitsopa S1,2, Bunpapong N1,2, Amonsin A1,2.

Author information: 1 Center of Excellences for Emerging and Re-emerging Infectious Diseases in Animals, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand. 2 Department of Veterinary Public Health, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand. 3 Department of Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.



Influenza A virus causes respiratory disease in both humans and animals. In this study, a survey of influenza A antibodies in domestic dogs and cats was conducted in 47 animal shelters in 19 provinces of Thailand from September 2011 to September 2014. One thousand and eleven serum samples were collected from 932 dogs and 79 cats. Serum samples were tested for influenza A antibodies using a multi-species competitive NP-ELISA and haemagglutination inhibition (HI) assay. The NP-ELISA results showed that 0.97% (9/932) of dogs were positive, but all cat samples were negative. The HI test against pandemic H1N1, human H3N2 and canine H3N2 showed that 0.64% (6/932) and 1.20% (1/79) of dogs and cats were positive, respectively. It is noted that all six serum samples (5 dogs and 1 cat) had antibodies against pandemic H1N1. In summary, a serological survey revealed the evidence of pandemic H1N1 influenza exposure in both dogs and cats in the shelters in Thailand.

KEYWORDS: Thailand; canine; influenza; serology

PMID: 30552750 DOI: 10.1111/zph.12551

Keywords: Influenza A; H1N1pdm09; Seroprevalence; Dogs; Cats; Thailand.


Consecutive #influenza #surveillance of #neuraminidase #mutations and neuraminidase inhibitor #resistance in #Japan (Influenza Other Respir Viruses, abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Influenza Other Respir Viruses. 2018 Dec 11. doi: 10.1111/irv.12624. [Epub ahead of print]

Consecutive influenza surveillance of neuraminidase mutations and neuraminidase inhibitor resistance in Japan.

Chong Y1, Matsumoto S2, Kang D2,3, Ikematsu H4.

Author information: 1 Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. 2 Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, Fukuoka, Japan. 3 Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 4 Japan Physicians Association, Influenza Study Group, Tokyo, Japan.




The large consumption of neuraminidase (NA) inhibitors (NAIs) for the treatment of influenza virus infections places Japan at risk of becoming the epicenter of the global spread of NAI-resistant viruses.


To clarify NA amino acid mutations of epidemic influenza viruses in Japan and their related NAI resistance METHODS: A total of 1791 samples, including 396 A/H1N1pdm09, 1117 A/H3N2, and 278 B isolates, were collected to determine of their 50% inhibitory concentration (IC50 ) values by NAIs (oseltamivir, zanamivir, peramivir, and laninamivir) during the Japanese seasons from 2011-12 to 2016-17. Then, 380 samples including 49 A/H1N1pdm09, 251 A/H3N2, and 80 B isolates, were sequenced for the entire NA genes.


NAI-resistant A/H1N1pdm09 viruses were detected at a frequency of 1.3% (5/396 isolates) in the epidemic seasons. None of the A/H3N2 and B viruses developed resistance to any of the four NAIs during the six seasons. Only five and 13 AA mutations were detected in the NA catalytic sites of A/H1N1pdm09 and A/H3N2 viruses, respectively. No mutations were observed in the catalytic sites of B viruses. Four of the five mutations in the catalytic sites of A/H1N1pdm09 consisted of H275Y, which was related to high resistance to oseltamivir and peramivir. Most (10/13) of the catalytic site mutations in A/H3N2 were associated with MDCK-passaged induction (D151G/N). Finally, no mutations related to substantial NAI resistance were detected in the A/H3N2 and B viruses examined.


These findings suggest that the NA catalytic sites of influenza viruses are well preserved. Even in Japan, no spread of NAI-resistant viruses has been observed, and A/H1N1pdm09 viruses carrying H275Y remain limited.

This article is protected by copyright. All rights reserved.

KEYWORDS: Influenza; mutation; neuraminidase; neuraminidase inhibitor; resistance

PMID: 30548432 DOI: 10.1111/irv.12624

Keywords: Antivirals; Drugs Resistance; Oseltamivir; Zanamivir; Peramivir; Laninamivir; H1N1pdm09; H3N2; Seasonal Influenza.


#Asymptomatic Middle East Respiratory Syndrome #Coronavirus (#MERS-CoV) #infection: Extent and implications for infection control: A systematic review (Travel Med Infect Dis., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Travel Med Infect Dis. 2018 Dec 11. pii: S1477-8939(18)30343-0. doi: 10.1016/j.tmaid.2018.12.003. [Epub ahead of print]

Asymptomatic Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: Extent and implications for infection control: A systematic review.

Al-Tawfiq JA1, Gautret P2.

Author information: 1 Specialty Internal Medicine, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Indiana University School of Medicine, Indianapolis, IN, USA; Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: jaffar.tawfiq@jhah.com. 2 Aix Marseille Univ, Institut de Recherche pour le Développement (IRD), Assistance Publique-Hôpitaux de Marseille (AP-HM), Service de Santé des Armées (SSA), Microbes Vecteurs Infections Tropicales et Méditerranéennes (VITROME), Institut Hospitalo-Universitaire-Méditerranée Infection (IHU-Méditerranée Infection), Marseille, France.




The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) emerged in 2012 and attracted an international attention as the virus caused multiple healthcare associated outbreaks. There are reports of the role of asymptomatic individuals play in the transmission of MERS-CoV, however, the exact role is now known.


The MEDLINE/PubMed and Scopus databases were searched for relevant papers published till August 2018 describing asymptomatic MERS-CoV infection.


A total of 10 papers were retrieved and included in the final analysis and review. The extent of asymptomatic MERS infection had increased with change in the policy of testing asymptomatic contacts. In early cases in April 2012-October 2013, 12.5% were asymptomatic among 144 PCR laboratory-confirmed MERS-CoV cases while in 2014 the proportion rose to 25.1% among 255 confirmed cases. The proportion of asymptomatic cases reported among pediatric confirmed MERS-CoV cases were higher (41.9%-81.8%). Overall, the detection rate of MERS cases among asymptomatic contacts when screened was less than 1% in the available studies included in this review. Asymptomatic individuals were less likely to have underlying condition compared to fatal cases. Of particular interest is that most of the identified pediatric cases were asymptomatic with no clear explanation.


The proportion of asymptomatic MERS cases were detected with increasing frequency as the disease progressed overtime. Those patients were less likely to have comorbid disease and contributed to the transmission of the virus.

Copyright © 2018. Published by Elsevier Ltd.

KEYWORDS: Healthcare associated outbreaks; MERS; Middle East Respiratory Syndrome Coronavirus

PMID: 30550839 DOI: 10.1016/j.tmaid.2018.12.003

Keywords: MERS-CoV.


The Triumph of Death, Pieter Bruegel the Elder (c.1562 – c.1563)



The Triumph of Death
Pieter Bruegel the Elder
Original Title: De Triomf van de Dood
Date: c.1562 – c.1563
Style: Northern Renaissance
Period: Brussels Period (1563-1569)
Series: Boschian series
Genre: religious painting
Media: oil, panel
Tag: Christianity, Hell, birth-and-death
Location: Museo del Prado, Madrid, Spain


Permissions: Public domain.

Source: WikiArt, full page: https://www.wikiart.org/en/pieter-bruegel-the-elder/the-triumph-of-death-1562-1