[Source: JAMA, full page: (LINK). Summary, edited.]
February 15, 2019
Enterovirus D68–Associated Acute Flaccid MyelitisRising to the Clinical and Research Challenges
Kevin Messacar, MD1,2; Kenneth L. Tyler, MD3,4
Author Affiliations: 1 Hospital Medicine and Pediatric Infectious Disease Sections, Department of Pediatrics, University of Colorado, Aurora; 2 Children’s Hospital Colorado, Aurora; 3 Neuroinfectious Disease Section, Department of Neurology, University of Colorado, Aurora; 4 Departments of Medicine and Immunology-Microbiology, University of Colorado, Aurora
JAMA. Published online February 15, 2019. doi:10.1001/jama.2019.1016
In the summer of 2014, the emergence of an upsurge in cases of a poliomyelitis-like paralytic syndrome in the United States, designated acute flaccid myelitis (AFM), generated substantial concern among the medical community and the public. There were 120 confirmed AFM cases in 34 states in the summer and fall of 2014. In 2016, this increased to 149 cases in 39 states, and in 2018 there were at least 210 confirmed cases from 40 states (as of February 10, 2019).1 These numbers compare to a likely baseline incidence of 22 to 35 cases per year scattered throughout the intervening years of 2015 and 2017.1
Corresponding Author: Kenneth L. Tyler, MD, University of Colorado Denver Health Sciences Center, 12700 E 19th Ave, Aurora, CO 80045 (firstname.lastname@example.org).
Published Online: February 15, 2019. doi:10.1001/jama.2019.1016
Conflict of Interest Disclosures: Dr Messacar reported receiving grants from NIAID during the conduct of the study and is a member of the CDC Acute Flaccid Myelitis Task Force. Dr Tyler reported receiving grants from NINDS and from Taiga Biotechnologies during the conduct of the study; personal fees from DNAtrix, grants from the Department of Veterans Affairs, and grants from NIH outside the submitted work. Dr Tyler is also a member of the CDC Acute Flaccid Myelitis Task Force.
Funding/Support: The authors acknowledge support from NIH grants 1K23AI128069 (Dr Messacar) and 1R01NS101208 (Dr Tyler).
Role of the Funder/Sponsor: Funding agencies had no role in the preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: This Viewpoint is not intended to represent the views of the CDC or CDC Task Force.
Additional Contributions: We thank Mark J. Abzug, MD, and Samuel R. Dominguez, MD (Infectious Diseases Section, Department of Pediatrics, University of Colorado School of Medicine and Children’s Hospital Colorado), for their suggestions and critical review of the manuscript.
Keywords: Enterovirus; AFM; AFP; EV-D68.