[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
Antiviral Res, 104742 2020 Feb 10 [Online ahead of print]
The Spike Glycoprotein of the New Coronavirus 2019-nCoV Contains a Furin-Like Cleavage Site Absent in CoV of the Same Clade
B Coutard 1, C Valle 2, X de Lamballerie 1, B Canard 2, N G Seidah 3, E Decroly 4
Affiliations: 1 Unité des Virus Émergents (UVE: Aix-Marseille Univ – IRD 190 – Inserm 1207 – IHU Méditerranée Infection), Marseille, France. 2 Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France. 3 Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM, Affiliated to the University of Montreal), 110 Pine Ave West, Montreal, QC, H2W1R7, Canada. 4 Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France. Electronic address: email@example.com.
PMID: 32057769 DOI: 10.1016/j.antiviral.2020.104742
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
Keywords: 2019-nCoV; Antivirals; Furin; Maturation protease; SARS-CoV; Spike protein.
Copyright © 2020. Published by Elsevier B.V.
Keywords: SARS-CoV-2; COVID-19.