Potential #Maternal and #Infant #Outcomes From (Wuhan) #Coronavirus 2019-nCoV Infecting #Pregnant Women: Lessons From SARS, MERS, and Other HCoV Infections (Viruses, abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Viruses, 12 (2) 2020 Feb 10

Potential Maternal and Infant Outcomes From (Wuhan) Coronavirus 2019-nCoV Infecting Pregnant Women: Lessons From SARS, MERS, and Other Human Coronavirus Infections

David A Schwartz 1, Ashley L Graham 2

Affiliations: 1 Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. 2 Department of Anthropology, University of Connecticut, Storrs, CT 06269, USA.

PMID: 32050635 DOI: 10.3390/v12020194



In early December 2019 a cluster of cases of pneumonia of unknown cause was identified in Wuhan, a city of 11 million persons in the People’s Republic of China. Further investigation revealed these cases to result from infection with a newly identified coronavirus, termed the 2019-nCoV. The infection moved rapidly through China, spread to Thailand and Japan, extended into adjacent countries through infected persons travelling by air, eventually reaching multiple countries and continents. Similar to such other coronaviruses as those causing the Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS), the new coronavirus was reported to spread via natural aerosols from human-to-human. In the early stages of this epidemic the case fatality rate is estimated to be approximately 2%, with the majority of deaths occurring in special populations. Unfortunately, there is limited experience with coronavirus infections during pregnancy, and it now appears certain that pregnant women have become infected during the present 2019-nCoV epidemic. In order to assess the potential of the Wuhan 2019-nCoV to cause maternal, fetal and neonatal morbidity and other poor obstetrical outcomes, this communication reviews the published data addressing the epidemiological and clinical effects of SARS, MERS, and other coronavirus infections on pregnant women and their infants. Recommendations are also made for the consideration of pregnant women in the design, clinical trials, and implementation of future 2019-nCoV vaccines.

Keywords: 2019-nCoV; China; MERS-CoV; Middle East respiratory syndrome; SARS-CoV; Wuhan coronavirus; Wuhan coronavirus outbreak; coronavirus; emerging infection; epidemic; maternal death; maternal morbidity; maternal mortality; pneumonia; pregnancy; pregnancy complications; severe acute respiratory syndrome.

Conflict of interest statement The authors declare no conflict of interest.

Keywords: COVID-19; SARS-CoV-2; Pregnancy; Pediatrics.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.