#Sofosbuvir Can Inhibit the Newly Emerged #Coronavirus (2019-nCoV) in Wuhan, #China (SSRN, abstract)

[Source: SSRN, full page: (LINK). Abstract, edited.]

Sofosbuvir Can Inhibit the Newly Emerged Coronavirus (2019-nCoV) in Wuhan, China

19 Pages Posted: 28 Jan 2020

Abdo Elfiky, Cairo University – Biophysics Department; Al Jouf University – College of Applied Medical Sciences

 

Abstract

A newly emerged Human Coronavirus (HCoV) is reported last month in Wuhan, China (2019-nCoV). Until today three deaths and more than 200 confirmed cases reported in China, Thailand, and Japan. HCoVs are zoonotic viruses that transmit from animals to humans through direct contact. Six different strains of HCoV were reported, during the last century, which has a different pathogenic burden and spread potentials. The two most famous strains of HCoVs that have significant health complications are the Severe Acute Respiratory Syndrome coronavirus (SARS CoV) and the Middle East Respiratory Syndrome coronavirus (MERS CoV). Based on the World Health Organization (WHO) reports, SARS HCoV is responsible for more than 8000 cases with confirmed 774 deaths. Additionally, MERS HCoV is responsible for 858 deaths out of about 2500 reported cases. In this study, the newly emerged Wuhan HCoV is targeted by anti-polymerase drugs including the approved Sofosbuvir and Ribavirin. Sequence analysis, modeling and docking are used to build a model for Wuhan 2019-nCoV RNA dependent RNA polymerase (RdRp). The results suggest the effectiveness of Sofosbuvir, IDX-184 and Ribavirin as a potent drug against the newly emerged HCoV disease.

Funding: None.

Declaration of Interest: All the authors declare that there is no competing interest in this work.

Keywords: Wuhan coronavirus; 2019-nCoV; RdRp; docking; structural bioinformatics; Sofosbuvir; nucleotide inhibitors

Suggested Citation: Elfiky, Abdo, Sofosbuvir Can Inhibit the Newly Emerged Coronavirus (2019-nCoV) in Wuhan, China (1/20/2020). Available at SSRN: https://ssrn.com/abstract=3523869

Keywords: Antivirals; Sofosbuvir; 2019-nCoV.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.