#Epidemiological and #Clinical Characteristics of 99 Cases of 2019-Novel #Coronavirus (2019-nCoV) #Pneumonia in #Wuhan, #China (SSRN, abstract)

[Source: SSRN, full page: (LINK). Abstract, edited.]

Epidemiological and Clinical Characteristics of 99 Cases of 2019-Novel Coronavirus (2019-nCoV) Pneumonia in Wuhan, China

26 Pages Posted: 27 Jan 2020

Nanshan Chen, Wuhan Jinyintan Hospital – Department of Tuberculosis and Respiratory; Min Zhou, Shanghai Jiao Tong University (SJTU); Xuan Dong, Wuhan Jinyintan Hospital – Department of Tuberculosis and Respiratory; Jieming Qu, Shanghai Jiao Tong University (SJTU); Fengyun Gong, Wuhan Jinyintan Hospital; Yang Han, Chinese Academy of Sciences (CAS) – State Key Laboratory of Virology; Yang Qiu, Chinese Academy of Sciences (CAS) – State Key Laboratory of Virology; Jingli Wang, Wuhan Jinyintan Hospital; Ying Liu, Wuhan Jinyintan Hospital; Yuan Wei, Wuhan Jinyintan Hospital – Department of Tuberculosis and Respiratory; Jia’an Xia, Wuhan Jinyintan Hospital – Department of Tuberculosis and Respiratory; Ting Yu, Wuhan Jinyintan Hospital – Department of Tuberculosis and Respiratory; Xinxin Zhang, Shanghai Jiao Tong University (SJTU) – Research Laboratory of Clinical Virology; Li Zhang, Wuhan Jinyintan Hospital – Department of Tuberculosis and Respiratory et al.
Abstract

Background:

Since December 2019, a novel coronavirus (2019-nCoV) associated pneumonia has emerged in Wuhan, China. The study aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia.

Methods:

99 cases admitted to Wuhan Jinyintan Hospital during January 1 to 20, 2020 and confirmed by real-time reverse-transcriptase polymerase-chain-reaction (RT-PCR) test were analyzed for epidemiological, demographic, clinical, radiological features, and laboratory data.

Findings:

Of the 99 patients with 2019-nCoV pneumonia, 49 (49%) had a history of exposure to the South China Seafood Wholesale Market. The average age of the patients was 62.85 ± 11.99 years, including 67 males and 32 females. 2019-nCoV was detected in all patients by RT-PCR, and some of them also by serological testing, and metagenomics sequencing analysis. 50 cases (50.51%) had chronic basic diseases. Patients had clinical manifestations of fever (83%), cough (82%), shortness of breath (31%), muscle aches (11%), headache (8%), fuzzy confusion (7%), chest pain (2%), and diarrhea (2%). According to imaging examination, 74 patients showed bilateral pneumonia (74.75%), 25 patients showed multiple mottled and ground-glass opacity, and 1 patient had pneumothorax. Most patients received antiviral, antibiotics, supportive treatments, continuous renal replacement therapy (CRRT) and extracorporeal membrane oxygenation (ECMO), and had good prognosis. 17 patients developed acute Respiratory Distress Syndrome (ARDS) and among them, 2 patients worsened in a short period of time and died of multiple organ failure.

Interpretation:

The infection of the 2019-nCoV can result in severe and even fatal respiratory disease like ARDS. It is very important to actively prevent complications and secondary infections, treat underlying diseases, and provide timely organ function support. Early diagnosis, early isolation, multiple treatment, and intervention of CRRT and ECMO when necessary can effectively reduce mortality caused by severe coronavirus pneumonia.

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Funding: National Key R&D Program of China (No. 2017YFC1309700)

Declaration of Interest: The author reports no conflicts of interest in this work.

Ethical Approval: The study was approved by Jinyintan Hospital Ethics Committee and written informed consent was obtained from all patients involved before enrolment.

Keywords: novel coronavirus; 2019-nCoV pneumonia; diagnosis; treatment

Suggested Citation: Chen, Nanshan and Zhou, Min and Dong, Xuan and Qu, Jieming and Gong, Fengyun and Han, Yang and Qiu, Yang and Wang, Jingli and Liu, Ying and Wei, Yuan and Xia, Jia’an and Yu, Ting and Zhang, Xinxin and Zhang, Li, Epidemiological and Clinical Characteristics of 99 Cases of 2019-Novel Coronavirus (2019-nCoV) Pneumonia in Wuhan, China (1/21/2020). Available at SSRN: https://ssrn.com/abstract=3523861

Keywords: 2019-nCoV; ARDS; ECMO.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.