#EVD68 #outbreak #detection through a syndromic disease #epidemiology #network (J Clin Virol., abstract)

[Source: Journal of Clinical Virology, full page: (LINK). Abstract, edited.]

Journal of Clinical Virology / Available online 16 January 2020, 104262 / In Press, Journal Pre-proof

Enterovirus D68 outbreak detection through a syndromic disease epidemiology network

Authors: Lindsay Meyers a, Jennifer Dien Bard bc, Ben Galvin a, Jeff Nawrocki a, Hubert G.M. Niesters d, Kathleen A. Stellrecht e, Kirsten St. George f, Judy A. Daly gh, Anne J. Blaschke i, Christine Robinson j, Huanyu Wang k, Camille V. Cook a, Ferdaus Hassan l, Sam R. Dominguez j, Kristin Pretty j, Samia Naccache b, Katherine E. Olin a, Benjamin M. Althousem n, Jay D. Jones a, Christine C. Ginocchioao p, Mark A. Poritz q2, Amy Leber k1, Rangaraj Selvarangan l1

{a} BioFire Diagnostics, Salt Lake City, UT, 84103, United States; {b} Department of Pathology and Laboratory Medicine, Children’s Hospital of Los Angeles, Los Angeles, CA 90027, United States; {c} Keck School of Medicine, University of Southern California, Los Angeles, CA 90039, United States; {d} The University of Groningen, University Medical Center Groningen, Department of Medical Microbiology, Division of Clinical Virology, Groningen, The Netherlands; {e} Department of Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY 12208, United States; {f} New York State Department of Health, Albany, NY, 12202, United States; {g} Department of Pathology, University of Utah, Salt Lake City, UT 84132, United States; {h} Division of Inpatient Medicine, Primary Children’s Hospital, Salt Lake City, UT 84132, United States; {i} Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84132, United States; {j} Department of Pathology and Laboratory Medicine, Children’s Colorado, Aurora, CO 80045, United States; {k} Department of Laboratory Medicine, Nationwide Children’s Hospital, Columbus, OH 43205, United States; {l} Department of Pathology and Laboratory Medicine, Children’s Mercy Hospital, Kansas City, MO 64108, United States; {m} Information School, University of Washington, Seattle, WA, 98105, United States; {n} Department of Biology, New Mexico State University, Las Cruces, NM, 88003, United States; {o} Global Medical Affairs, bioMérieux, Durham, NC 27712, United States; {p}
Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, United States; {q} BioFire Defense, Salt Lake City, UT 84107, United States

Received 3 June 2019, Revised 8 January 2020, Accepted 14 January 2020, Available online 16 January 2020. DOI: https://doi.org/10.1016/j.jcv.2020.104262



  • An algorithm to predict the presence enterovirus D68 among hinovirus/Enterovirus results obtained from a commercial respiratory disease diagnostic test was developed
  • The algorithm was used in conjunction with test results exported to a cloud-based epidemiology network for use in real-time monitoring and historical outbreak prediction
  • Historical outbreak predictions coincide with known periods of high EV-D68 circulation in 2014 and 2016
  • The algorithm alerted participating clinical laboratories of the potential circulation of EV-D68 in 2018, prompting clinical testing for EV-D68 at one site

Keywords: EV-D68; USA.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.