Emergence of an #Eurasian #avian-like #swine #influenza A (#H1N1) virus from #mink in #China (Vet Microbiol., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Vet Microbiol. 2020 Jan;240:108509. doi: 10.1016/j.vetmic.2019.108509. Epub 2019 Nov 22.

Emergence of an Eurasian avian-like swine influenza A (H1N1) virus from mink in China.

Liu J1, Li Z1, Cui Y1, Yang H1, Shan H1, Zhang C2.

Author information: 1 College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China. 2 College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China. Electronic address: zhangchuanmei100@163.com.

 

Abstract

We evaluated the phenotype and genotype of a fatal influenza/canine distemper virus coinfection found in farmed mink in China. We identified a novel subtype H1N1 influenza virus strain from the lungs of infected mink designated A/Mink/Shandong/1121/2017 (H1N1). The results of phylogenetic analysis of 8 gene fragments of the H1N1 strain showed the virus was a swine origin triple-reassortant H1N1 influenza virus: with the 2009 pandemic H1N1 segments (PB2, PB1, PA, NP and M), Eurasian avian-like H1N1 swine segments (HA and NA) and classical swine (NS) lineages. The EID50/0.2 mL of this strain was 10-6.2 and pathogenicity tests were 100 % lethal in a mouse model of infection. We found that while not lethal and lacking any overt signs of infection in mink, the virus could proliferate in the upper respiratory tracts and the animals were converted to seropositive for the HA protein.

Copyright © 2019 Elsevier B.V. All rights reserved.

KEYWORDS: Eurasian avian-like swine influenza virus; H1N1; Mink influenza virus; Phylogenetic analysis; Reassortment

PMID: 31902506 DOI: 10.1016/j.vetmic.2019.108509

Keywords: Avian Influenza; Swine Influenza; H1N1pdm09; H1N1; Reassortant strain; Wildlife; China.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.