[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
J Med Virol. 2019 Dec 12. doi: 10.1002/jmv.25654. [Epub ahead of print]
A preliminary survey of ZIKA virus infection by nucleic acid test in the volunteer blood donor samples in Shenzhen China.
Zheng X1, Zeng J1, Xu X1, Liu Y2, Heng L1, Wen X1, Li S3, Xu M3, Wu S3, Chen Y3, Chen L3,4.
Author information: 1 Shenzhen Blood Center, Shenzhen, Guangdong, China, 518035. 2 Shenzhen Baoan District Central Blood Station, Shenzhen, Guangdong, China. 3 Provincial Key Laboratory for Transfusion-transmitted Infectious Diseases, Institute of Blood Transfusion, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Chengdu, Sichuan, China, 610052. 4 Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, M5G1L6, Canada.
Although ZIKA virus infection is mainly transmitted through mosquito bite, it can also be transmitted through blood transfusion. More than 500,000 cases of ZIKA virus infection were reported in the Americas from 2015 to 2016. Up till now, over ten cases of imported zika virus infection have been reported due to frequent international exchanges in Shenzhen city of Guangdong Province, China. Unfortunately, there were no data on ZIKA virus infection in Chinese blood donors because it has not been included in routine screening for volunteer blood donors. As such, we performed a preliminary survey of the prevalence of ZIKA virus infection among volunteer blood donors in Shenzhen, China to assess the potential risk of ZIKA virus infection through transfusion.
STUDY DESIGN AND METHODS:
A total of 9,626 blood donor samples were collected and ZIKA RNA was detected by TMA nucleic acid amplification method with the Panther nucleic acid automatic analysis system of Spain GRIFOLS including Procleix ZIKA Virus Assay reagent. All experiments in this study were conducted in accordance with the standard operating procedure (SOP) of the blood center.
Of the 9626 donor blood samples tested, None of these samples was ZIKV RNA reactive. There was no positive case from ZIKA Virus RNA screening in this preliminary survey.
There was no ZIKA virus presence in blood donors in Shenzhen, China from this preliminary survey. The potential risk of ZIKA virus infection by transfusion is low in Shenzhen at this moment. Therefore there is no need to add ZIKA virus nucleic acid test as a routine screening for blood donors.
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KEYWORDS: Blood < Epidemiology; Endemic infection < Epidemiology; Yellow fever virus < Virus classification
PMID: 31829444 DOI: 10.1002/jmv.25654
Keywords: Zika Virus; Diagnostic tests; Blood safety; China.