[Source: Antimicrobial Agents and Chemotherapy, full page: (LINK). Abstract, edited.]
Impact of Candida auris infection in a neutropenic murine model
Steven R. Torres, Amber Pichowicz, Fernando Torres-Velez, Renjie Song, Navjot Singh, Erica Lasek-Nesselquist, Magdia De Jesus
Candida auris has become a global public health threat due to its multidrug resistance and persistence. Currently, there are limited murine models to study C. auris infection. These models use a combination of cyclophosphamide and cortisone acetate that suppress both innate and adaptive immunity. Here we compare C. auris infection in two neutrophil depleted (ND) murine models, where innate immunity is targeted using the monoclonal antibodies 1A8 and RB6-8C5.
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Keywords: Antibiotics; Drugs Resistance; Candida auris; Animal models.