#Key #aminoacid residues of #neuraminidase involved in #influenza A virus #entry (Pathog Dis., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Pathog Dis. 2019 Nov 8. pii: ftz063. doi: 10.1093/femspd/ftz063. [Epub ahead of print]

Key amino acid residues of neuraminidase involved in influenza A virus entry.

Chen F1, Liu T1, Xu J1, Huang Y1, Liu S1, Yang J1.

Author information: 1 Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.

 

Abstract

Generally, influenza virus neuraminidase (NA) plays a critical role in the release stage of influenza virus. Recently, it has been found that NA may promote influenza virus to access the target cells. However, the mechanism remain unclear. Here, we reported that peramivir indeed possessed anti-influenza A virus (IAV) activity in the stage of viral entry. Importantly, we verified the critical residues of influenza NA involved in the viral entry. As a result, peramivir as an efficient NA inhibitor could suppress the initiation of IAV infection. Furthermore, mutational analysis showed NA might be associated with viral entry via amino acids residues R118, E119, D151, R152, W178, I222, E227, E276, R292 and R371. Our results demonstrated neuraminidase must contain the key amino acid residues can involve in IAV entry.

© FEMS 2019.

KEYWORDS: Influenza A virus; neuraminidase; neuraminidase active site; peramivir; viral entry

PMID: 31702775 DOI: 10.1093/femspd/ftz063

Keywords: Influenza A; Peramivir; Antivirals; Viral pathogenesis.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.