Broad and Efficient Control of #Klebsiella #Pathogens by #Peptidoglycan-Degrading and Pore-Forming #Bacteriocins #Klebicins (Sci Rep., abstract)

[Source: Scientific Reports, full page: (LINK). Abstract, edited.]

Broad and Efficient Control of Klebsiella Pathogens by Peptidoglycan-Degrading and Pore-Forming Bacteriocins Klebicins

Erna Denkovskienė, Šarūnas Paškevičius, Audrius Misiūnas, Benita Stočkūnaitė, Urtė Starkevič, Astra Vitkauskienė, Simone Hahn-Löbmann, Steve Schulz, Anatoli Giritch, Yuri Gleba & Aušra Ražanskienė

Scientific Reports, volume 9, Article number: 15422 (2019)

 

Abstract

Gram-negative bacteria belonging to the genus Klebsiella are important nosocomial pathogens, readily acquiring resistance to all known antibiotics. Bacteriocins, non-antibiotic antibacterial proteins, have been earlier proposed as potential therapeutic agents for control of other Gram-negative species such as Escherichia, Pseudomonas and Salmonella. This study is the first report describing pore-forming and peptidoglycan-degrading bacteriocins klebicins from Klebsiella. We have identified, cloned, expressed in plants and characterized nine pore-forming and peptidoglycan-degrading bacteriocins from different Klebsiella species. We demonstrate that klebicins can be used for broad and efficient control of 101 of the 107 clinical isolates representing five Klebsiella species, including multi-drug resistant pathovars and pathovars resistant to carbapenem antibiotics.

Keywords: Antibiotics; Drugs Resistance; Klebsiella pneumoniae; Carbapenem; Bacteriocins.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.