#Neisseria meningitidis isolated from #patients in #MSMs (Rev Argent Microbiol., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Rev Argent Microbiol. 2019 Oct 15. pii: S0325-7541(19)30079-3. doi: 10.1016/j.ram.2019.03.009. [Epub ahead of print]

[Neisseria meningitidis isolated from patients in men who have sex with men].

[Article in Spanish]

García SD1, Sorhuet-Pereira C2, Perazzi BE3, Losada ME3, Cabellos Astorga G3, Casco RH4, Vay CA3, Mollerach ME5, Famiglietti ÁMR3.

Author information: 1 Cátedra de Microbiología Clínica, Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina. Electronic address: biosgarcia@yahoo.com.ar. 2 Cátedra de Microbiología, Departamento de Microbiología, Inmunología y Genética, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina. 3 Cátedra de Microbiología Clínica, Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina. 4 Programa de ETS, Hospital de Clínicas, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina. 5 Cátedra de Microbiología, Departamento de Microbiología, Inmunología y Genética, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina; CONICET, Buenos Aires, Argentina.

 

Abstract

During the periods 2000-2004 and 2014-2015, Neisseria meningitidis was investigated in men who have sex with men, 1143 and 544 respectively, who consulted in the sexually-transmitted disease program. Prevalence, serogroup distribution and susceptibility to antibiotics were determined. Pharyngeal, rectal and urethral swabs were cultivated on selective Thayer-Martin modified medium. The identification was performed by biochemical tests and mass spectrometry by MALDI-TOF. Serogroups B, C, W and Y were investigated by PCR in 85 isolates recovered from the pharynx belonging to the second period. MICs of penicillin, ceftriaxone, rifampicin, azithromycin and ciprofloxacin were determined for 66 and 102 isolates from periods 1 and 2 respectively, according to CLSI. The prevalence of N. meningitidis was 17.8% and 28.1%, in periods 1 and 2 respectively; the isolates were mainly recovered from the pharynx. The distribution of serogroups was B 31.5%; Y 7.6%; W 3.3% and 9.8% non-capsulated and the rest would belong to other serogroups. Isolates classified as intermediate to penicillin were 34.8% and 63.7% (first and second periods, respectively); moreover, 11.8% of the isolates from the second period were resistant. All isolates were susceptible to ceftriaxone, to ciprofloxacin (except 3 isolates with MIC values between 0.25 and 0.5μg/ml), 3% were resistant to rifampicin and 2% were not susceptible to azithromicin. The prevalence of N. meningitidis carriage in men who have sex with men was high with a high rate of penicillin non-susceptible isolates. B was the prevalent serogroup.

Copyright © 2019 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.

KEYWORDS: Neisseria meningitidis; Resistance; Resistencia; Serogroup; Serogrupo

PMID: 31628000 DOI: 10.1016/j.ram.2019.03.009

Keywords: Antibiotics; Drugs Resistance; Penicillin; Neisseria meningitidis; Argentina.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.