[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
Am J Trop Med Hyg. 2019 Oct 7. doi: 10.4269/ajtmh.19-0357. [Epub ahead of print]
Isolation of Mayaro Virus from a Venezuelan Patient with Febrile Illness, Arthralgias, and Rash: Further Evidence of Regional Strain Circulation and Possible Long-Term Endemicity.
Blohm GM1,2,3, Márquez-Colmenarez MC4,1, Lednicky JA2,3, Bonny TS5, Mavian C6,2, Salemi M6,2, Delgado-Noguera L1, Morris JG6,7,2, Paniz-Mondolfi AE8,9,1.
Author information: 1 Venezuelan Science Research Incubator, Zoonoses and Emerging Pathogens Collaborative Network, Barquisimeto, Venezuela. 2 Emerging Pathogens Institute, University of Florida, Gainesville, Florida. 3 Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, Florida. 4 Department of Medicine, Universidad Centroccidental Lisandro Alvarado, Barquisimeto, Venezuela. 5 Department of Pathology, School of Medicine, The Johns Hopkins University, Baltimore, Maryland. 6 Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida. 7 Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida. 8 Laboratory of Cellular Signaling and Parasite Biochemistry, Instituto de Estudios Avanzados (IDEA), Caracas, Venezuela. 9 Instituto Diagnóstico Barquisimeto (IDB), Barquisimeto, Venezuela.
Fifty-two febrile patients living in Barquisimeto, Venezuela, were screened for arbovirus infection by virus culture during an outbreak of what was thought to be Zika virus infection. We report identification of Mayaro virus (MAYV) on culture of plasma from one patient, an 18-year-old woman with acute febrile illness, arthralgias, and psoriasiform rash. The strain was sequenced and was found to be most closely related to a 1999 strain from French Guiana, which, in turn, was related to two 2014 strains from Haiti. By contrast, previously reported outbreak-related MAYV strains from a sylvatic area 80 miles from where the case patient lived were most closely related to Peruvian isolates. The two strain groups show evidence of having diverged genetically approximately 100 years ago.
PMID: 31595869 DOI: 10.4269/ajtmh.19-0357
Keywords: Mayaro Virus; Venezuela.