#Human-to-Human #Transmission of #Influenza A(H3N2#) Virus with Reduced Susceptibility to #Baloxavir, #Japan, February 2019 (Emerg Infect Dis., abstract)

[Source: US Centers for Disease Control and Prevention (CDC), Emerging Infectious Diseases Journal, full page: (LINK). Abstract, edited.]

Volume 25, Number 11—November 2019 / Dispatch

Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019

Emi Takashita  , Masataka Ichikawa, Hiroko Morita, Rie Ogawa, Seiichiro Fujisaki, Masayuki Shirakura, Hideka Miura, Kazuya Nakamura, Noriko Kishida, Tomoko Kuwahara, Hiromi Sugawara, Aya Sato, Miki Akimoto, Keiko Mitamura, Takashi Abe, Masahiko Yamazaki, Shinji Watanabe, Hideki Hasegawa, and Takato Odagiri

Author affiliations: National Institute of Infectious Diseases, Tokyo, Japan (E. Takashita, H. Morita, R. Ogawa, S. Fujisaki, M. Shirakura, H. Miura, K. Nakamura, N. Kishida, T. Kuwahara, H. Sugawara, A. Sato, M. Akimoto, S. Watanabe, H. Hasegawa, T. Odagiri); Ichikawa Children’s Clinic, Kanagawa, Japan (M. Ichikawa); Eiju General Hospital, Tokyo (K. Mitamura); Abe Children’s Clinic, Kanagawa (T. Abe); Zama Children’s Clinic, Kanagawa (M. Yamazaki)



In 2019, influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic gene, which confers reduced susceptibility to baloxavir, were detected in Japan in an infant without baloxavir exposure and a baloxavir-treated sibling. These viruses’ whole-genome sequences were identical, indicating human-to-human transmission. Influenza virus isolates should be monitored for baloxavir susceptibility.

Keywords: Influenza A; H3N2; Seasonal Influenza; Antivirals; Drugs resistance; Baloxavir; Japan.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.