[Source: Journal of Infectious Diseases, full page: (LINK). Abstract, edited.]
Micronutrients, immunological parameters, and dengue virus infection in coastal Ecuador: A nested case-control study in an infectious disease surveillance program
Julia L Finkelstein, Susannah Colt, Alexander J Layden, Jesse T Krisher,Anna M Stewart-Ibarra, Mark Polhemus, Efraín Beltrán-Ayala, Julia M Tedesco,Washington B Cárdenas, Timothy Endy, Saurabh Mehta
The Journal of Infectious Diseases, jiz427, https://doi.org/10.1093/infdis/jiz427
Published: 20 August 2019
Micronutrients are known to modulate host immunity and there is limited literature on this association in the context of dengue virus infection (DENV).
Using a nested case-control design in a surveillance program, we measured anthropometry; nutritional biomarkers including serum ferritin, soluble transferrin receptor, retinol-binding protein (RBP), 25-hydroxy vitamin D, folate, and vitamin B12; and a panel of immune response markers and compared these measures across four illness categories: healthy control, non-febrile DENV, other febrile illness (OFI), and apparent DENV using multivariate polytomous logistic regression models.
Among 142 participants, serum ferritin (ng/mL) was associated with apparent DENV compared to healthy controls (OR 2.66; CI 1.53, 4.62; p=0.001), and RBP concentrations (µmol/L) were associated with apparent DENV (OR 0.03; CI 0.00, 0.30; p=0.003) and OFI (OR 0.02; CI 0.00, 0.24; p=0.003). In a subset of 71 participants, IL-15 levels (MFI) were positively associated with apparent DENV (OR 1.09; CI 1.03, 1.14; p=0.001) and negatively associated with non-febrile DENV (OR 0.89; CI 0.80, 0.99; p=0.03) compared to healthy controls.
After adjusting for the acute phase response, serum ferritin and RBP concentrations were associated with apparent DENV and may represent biomarkers of clinical importance in the context of dengue illness.
Issue Section: Major Article
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Keywords: Dengue fever; Ferritin; Ecuadore.