#Micronutrients, #immunological parameters, and #dengue virus #infection in coastal #Ecuador: A nested case-control study in an infectious disease #surveillance program (J Infect Dis., abstract)

[Source: Journal of Infectious Diseases, full page: (LINK). Abstract, edited.]

Micronutrients, immunological parameters, and dengue virus infection in coastal Ecuador: A nested case-control study in an infectious disease surveillance program

Julia L Finkelstein, Susannah Colt, Alexander J Layden, Jesse T Krisher,Anna M Stewart-Ibarra, Mark Polhemus, Efraín Beltrán-Ayala, Julia M Tedesco,Washington B Cárdenas, Timothy Endy, Saurabh Mehta

The Journal of Infectious Diseases, jiz427, https://doi.org/10.1093/infdis/jiz427

Published: 20 August 2019




Micronutrients are known to modulate host immunity and there is limited literature on this association in the context of dengue virus infection (DENV).


Using a nested case-control design in a surveillance program, we measured anthropometry; nutritional biomarkers including serum ferritin, soluble transferrin receptor, retinol-binding protein (RBP), 25-hydroxy vitamin D, folate, and vitamin B12; and a panel of immune response markers and compared these measures across four illness categories: healthy control, non-febrile DENV, other febrile illness (OFI), and apparent DENV using multivariate polytomous logistic regression models.


Among 142 participants, serum ferritin (ng/mL) was associated with apparent DENV compared to healthy controls (OR 2.66; CI 1.53, 4.62; p=0.001), and RBP concentrations (µmol/L) were associated with apparent DENV (OR 0.03; CI 0.00, 0.30; p=0.003) and OFI (OR 0.02; CI 0.00, 0.24; p=0.003). In a subset of 71 participants, IL-15 levels (MFI) were positively associated with apparent DENV (OR 1.09; CI 1.03, 1.14; p=0.001) and negatively associated with non-febrile DENV (OR 0.89; CI 0.80, 0.99; p=0.03) compared to healthy controls.


After adjusting for the acute phase response, serum ferritin and RBP concentrations were associated with apparent DENV and may represent biomarkers of clinical importance in the context of dengue illness.

dengue, micronutrients

Issue Section: Major Article

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Keywords: Dengue fever; Ferritin; Ecuadore.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.