#Isolation of highly pathogenic #H5N6 #avian #influenza virus in Southern #Vietnam with #genetic similarity to those infecting #humans in #China (Transbound Emerg Dis., abstract)

[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

Transbound Emerg Dis. 2019 Jul 15. doi: 10.1111/tbed.13294. [Epub ahead of print]

Isolation of highly pathogenic H5N6 avian influenza virus in Southern Vietnam with genetic similarity to those infecting humans in China.

Tsunekuni R1,2, Sudo K3, Nguyen PT4, Luu BD4, Phuong TD4, Tan TM4, Tung N5, Mine J1,2, Nakayama M1,2, Tanikawa T1,2, Sharshov K6, Takemae N1,2, Saito T1,2,7.

Author information: 1 Division of Transboundary Animal Disease, National Institute of Animal Health, NARO, Tsukuba, Japan. 2 Thailand-Japan Zoonotic Diseases Collaboration Center, Bangkok, Thailand. 3 National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Japan. 4 Regional Animal Health Office No. 6, Department of Animal Health, Vietnam. 5 Division of International Cooperation and Communications, Department of Animal Health, Hanoi, Vietnam. 6 Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia. 7 United Graduate School of Veterinary Sciences, Gifu University, Japan.



Since 2013, H5N6 highly pathogenic avian influenza viruses (HPAIVs) have been responsible for outbreaks in poultry and wild birds around Asia. H5N6 HPAIV is also a public concern due to sporadic human infections being reported in China. In the current study, we isolated an H5N6 HPAIV strain (A/Muscovy duck/Long An/AI470/2018; AI470) from an outbreak at a Muscovy duck farm in Long An Province in Southern Vietnam in July 2018 and genetically characterized it. Basic Local Alignment Search Tool (BLAST) analysis revealed that the eight genomic segments of AI470 were most closely related (99.6-99.9%) to A/common gull/Saratov/1676/2018 (H5N6), which was isolated in October 2018 in Russia. Furthermore, AI470 also shared 99.4-99.9% homology with A/Guangxi/32797/2018, an H5N6 HPAIV strain that infected humans in China in 2018. Phylogenetic analyses of the entire genome showed that AI470 was directly derived from H5N6 HPAIVs that were in South China from 2015 to 2018 and clustered with four H5N6 HPAIV strains of human origin in South China from 2017 to 2018. This indicated that AI470 was introduced into Vietnam from China. In addition, molecular characteristics related to mammalian adaptation among the recent human H5N6 HPAIV viruses, except PB2 E627K, were shared by AI470. These findings are cause for concern since H5N6 HPAIV strains that possess a risk of human infection have crossed the Chinese border.

This article is protected by copyright. All rights reserved.

KEYWORDS: G1.1; Highly pathogenic avian influenza virus; South China; Vietnam; human infection

PMID: 31309743 DOI: 10.1111/tbed.13294

Keywords: Avian Influenza; H5N6; Poultry; Vietnam.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.