[Source: Antimicrobial Agents and Chemotherapy, full page: (LINK). Abstract, edited.]
Efficacy of a multimechanistic monoclonal antibody combination against Staphylococcus aureus surgical site infections in mice
Roger V. Ortines, Yu Wang, Haiyun Liu, Dustin A. Dikeman, Bret L. Pinsker, Robert J. Miller, Sophia E. Kim, Nicole E. Ackerman, Joe F. Rizkallah, LeeAnn T. Marcello, Taylor S. Cohen,Christine Tkaczyk, Bret R. Sellman, Lloyd S. Miller
Surgical site infections (SSI) are commonly caused by Staphylococcus aureus. Here, we report that a combination of three monoclonal antibodies (MEDI6389) that neutralize S. aureus α-toxin, clumping factor A and four leukocidins (LukSF, LukED, HlgAB and HlgCB) plus vancomycin had enhanced efficacy than control antibody plus vancomycin in two mouse models of S. aureus SSI. Therefore, mAb-based neutralization of multiple S. aureus virulence factors could provide an adjunctive perioperative approach to combat S. aureus SSI.
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Keywords: Antibiotics; Drugs Resistance; Staphylococcus aureus; Monoclonal antibodies; Animal models.