Efficacy of a multimechanistic #monoclonal #antibody combination against #Staphylococcus aureus #surgical site #infections in mice (Antimicrob Agents Chemother., abstract)

[Source: Antimicrobial Agents and Chemotherapy, full page: (LINK). Abstract, edited.]

Efficacy of a multimechanistic monoclonal antibody combination against Staphylococcus aureus surgical site infections in mice

Roger V. Ortines, Yu Wang, Haiyun Liu, Dustin A. Dikeman, Bret L. Pinsker, Robert J. Miller, Sophia E. Kim, Nicole E. Ackerman, Joe F. Rizkallah, LeeAnn T. Marcello, Taylor S. Cohen,Christine Tkaczyk, Bret R. Sellman, Lloyd S. Miller

DOI: 10.1128/AAC.00346-19

 

ABSTRACT

Surgical site infections (SSI) are commonly caused by Staphylococcus aureus. Here, we report that a combination of three monoclonal antibodies (MEDI6389) that neutralize S. aureus α-toxin, clumping factor A and four leukocidins (LukSF, LukED, HlgAB and HlgCB) plus vancomycin had enhanced efficacy than control antibody plus vancomycin in two mouse models of S. aureus SSI. Therefore, mAb-based neutralization of multiple S. aureus virulence factors could provide an adjunctive perioperative approach to combat S. aureus SSI.

Copyright © 2019 American Society for Microbiology. All Rights Reserved.

Keywords: Antibiotics; Drugs Resistance; Staphylococcus aureus; Monoclonal antibodies; Animal models.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.

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