[Source: F1000 Research, full page: (LINK). Abstract, edited.]
Contrast-associated acute kidney injury: does it really exist, and if so, what to do about it? [version 1; peer review: 2 approved]
Wim Vandenberghe 1, Eric Hoste 1,2
Author details: 1 Department of Intensive Care Medicine, University Hospital Ghent, Ghent University, C. Heymanslaan 10, 9000 Ghent, Belgium; 2 Research Foundation-Flanders (FWO), Egmontstraat 5, 1000 Brussels, Belgium
For decades, when contrast agents are administrated, physicians have been concerned because of the risk of inducing acute kidney injury (AKI). Recent literature questions the existence of AKI induced by contrast, but animal studies clearly showed harmful effects. The occurrence of contrast-associated AKI was likely overestimated in the past because of confounders for AKI. Several strategies have been investigated to reduce contrast-associated AKI but even for the most important one, hydration, there are conflicting data. Even if the occurrence rate of contrast-associated AKI is low, AKI is related to worse outcomes. Therefore, besides limiting contrast agent usage, general AKI preventive measurements should be applied in at-risk patients.
Keywords: Acute kidney injury, Contrast media, Coronary angiography, Angiography, Tomography X-Ray Computed, Intensive Care Unit
Corresponding author: Wim Vandenberghe
Competing interests: No competing interests were disclosed.
Grant information: The author(s) declared that no grants were involved in supporting this work.
Copyright: © 2019 Vandenberghe W and Hoste E. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
How to cite: Vandenberghe W and Hoste E. Contrast-associated acute kidney injury: does it really exist, and if so, what to do about it? [version 1; peer review: 2 approved]. F1000Research 2019, 8(F1000 Faculty Rev):753 (https://doi.org/10.12688/f1000research.16347.1)
First published: 29 May 2019, 8(F1000 Faculty Rev):753 (https://doi.org/10.12688/f1000research.16347.1)
Latest published: 29 May 2019, 8(F1000 Faculty Rev):753 (https://doi.org/10.12688/f1000research.16347.1)
Keywords: Drugs safety; Diagnostic imaging; Acute kidney injury.