#Contrast-associated acute #kidney #injury: does it really exist, and if so, what to do about it? (F1000Res., abstract)

[Source: F1000 Research, full page: (LINK). Abstract, edited.]

Contrast-associated acute kidney injury: does it really exist, and if so, what to do about it? [version 1; peer review: 2 approved]

Wim Vandenberghe 1, Eric Hoste 1,2

Author details: 1 Department of Intensive Care Medicine, University Hospital Ghent, Ghent University, C. Heymanslaan 10, 9000 Ghent, Belgium; 2 Research Foundation-Flanders (FWO), Egmontstraat 5, 1000 Brussels, Belgium



For decades, when contrast agents are administrated, physicians have been concerned because of the risk of inducing acute kidney injury (AKI). Recent literature questions the existence of AKI induced by contrast, but animal studies clearly showed harmful effects. The occurrence of contrast-associated AKI was likely overestimated in the past because of confounders for AKI. Several strategies have been investigated to reduce contrast-associated AKI but even for the most important one, hydration, there are conflicting data. Even if the occurrence rate of contrast-associated AKI is low, AKI is related to worse outcomes. Therefore, besides limiting contrast agent usage, general AKI preventive measurements should be applied in at-risk patients.

Keywords: Acute kidney injury, Contrast media, Coronary angiography, Angiography, Tomography X-Ray Computed, Intensive Care Unit

Corresponding author: Wim Vandenberghe

Competing interests: No competing interests were disclosed.

Grant information: The author(s) declared that no grants were involved in supporting this work.

Copyright:  © 2019 Vandenberghe W and Hoste E. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

How to cite: Vandenberghe W and Hoste E. Contrast-associated acute kidney injury: does it really exist, and if so, what to do about it? [version 1; peer review: 2 approved]. F1000Research 2019, 8(F1000 Faculty Rev):753 (https://doi.org/10.12688/f1000research.16347.1)

First published: 29 May 2019, 8(F1000 Faculty Rev):753 (https://doi.org/10.12688/f1000research.16347.1)

Latest published: 29 May 2019, 8(F1000 Faculty Rev):753 (https://doi.org/10.12688/f1000research.16347.1)

Keywords: Drugs safety; Diagnostic imaging; Acute kidney injury.


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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.