#WNV #infection in individuals with pre-existing #Usutu virus #immunity, northern #Italy, 2018 (Euro Surveill., abstract)

[Source: Eurosurveillance, full page: (LINK). Abstract, edited.]

West Nile virus infection in individuals with pre-existing Usutu virus immunity, northern Italy, 2018

Alessandro Sinigaglia1, Monia Pacenti2, Thomas Martello1, Silvana Pagni1,2, Elisa Franchin1,2, Luisa Barzon1,2

Affiliations: 1 Department of Molecular Medicine, University of Padova, Padova, Italy; 2 Microbiology and Virology Unit, Padova University Hospital, Padova, Italy

Correspondence:  Luisa Barzon

Citation style for this article: Sinigaglia Alessandro, Pacenti Monia, Martello Thomas, Pagni Silvana, Franchin Elisa, Barzon Luisa. West Nile virus infection in individuals with pre-existing Usutu virus immunity, northern Italy, 2018. Euro Surveill. 2019;24(21):pii=1900261. https://doi.org/10.2807/1560-7917.ES.2019.24.21.1900261

Received: 27 Apr 2019;   Accepted: 22 May 2019

 

Abstract

In 2018, there was a large West Nile virus (WNV) outbreak in northern Italy. We observed five atypical cases of WNV infection that were characterised by the presence of WNV RNA and WNV IgG at the time of diagnosis, but no IgM response during follow-up. Neutralisation assays demonstrated pre-existing Usutu virus immunity in all patients. Besides challenging diagnosis, the immunological crosstalk between the two viruses warrants further investigation on possible cross-protection or infection enhancement effects.

©  This work is licensed under a Creative Commons Attribution 4.0 International License.

Keywords: WNV; Usutu virus; ADE; Italy.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.

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