[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
Front Neurol. 2019 Apr 30;10:435. doi: 10.3389/fneur.2019.00435. eCollection 2019.
Guillain-Barré Syndrome Associated With Zika Virus Infection: A Prospective Case Series From Mexico.
Soto-Hernández JL1, Ponce de León Rosales S2, Vargas Cañas ES3, Cárdenas G1, Carrillo Loza K4, Díaz-Quiñonez JA5,6, López-Martínez I5, Jiménez-Corona ME7, Ruiz-Matus C7, Kuri Morales P6.
Author information: 1 Department of Infectious Diseases National Institute of Neurology and Neurosurgery Manuel Velasco Suárez, Mexico City, Mexico. 2 Programa Universitario de Investigación en Salud UNAM, Mexico City, Mexico. 3 Neuromuscular Clinic, Department of Neurology, National Institute of Neurology and Neurosurgery Manuel Velasco Suárez, Mexico City, Mexico. 4 Department of Neurology, National Institute of Neurology and Neurosurgery Manuel Velasco Suárez, Mexico City, Mexico. 5 Instituto de Diagnóstico y Referencia Epidemiológicos “Dr. Manuel Martínez Báez”, Mexico City, Mexico. 6 División de Estudios de Postgrado, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico. 7 Dirección General de Epidemiología, Mexico City, Mexico.
On May 2016, anticipating the rainy season from June to October in Mexico, we expected an increase in cases of Zika virus (ZIKV) infections. With the goal of identifying cases of GBS associated with ZIKV infection, a prospective joint study was conducted by a reference center for neurological patients and the Secretary of Health in Mexico City from July 2016 to November 2016.
Serum, cerebrospinal fluid, urine, and saliva were tested by RT-PCR for ZIKV, dengue virus, and chikungunya virus in patients referred from states with reported transmissions of ZIKV infection, and with clinical symptoms of GBS according to the Brighton Collaboration criteria. Clinical, electrophysiological, and long-term disability data were collected.
In the year 2016 twenty-eight patients with GBS were diagnosed at our institute. In five hospitalized patients with GBS, RT-PCR was positive to ZIKV in any collected specimen. Dengue and chikungunya RT-PCR results were negative. All five patients had areflexic flaccid weakness, and cranial nerves affected in three. Electrophysiological patterns were demyelinating in two patients and axonal in three. Three patients were discharged improved in 10 days or less, and two patients required intensive care unit admission, and completely recovered during follow-up.
Our results are similar to those reported from the state of Veracruz, Mexico, in which out of 33 samples of urine of patients with GBS two had a positive RT-PCR for ZIKV. Simultaneous processing of serum, CSF, urine, and saliva by RT-PCR may increase the success of diagnosis of GBS associated to ZIKV.
KEYWORDS: Guillain–Barré Syndrome; RT-PCR; Zika virus; cranial neuropathies multiple; flavivirus infection
PMID: 31114537 PMCID: PMC6502985 DOI: 10.3389/fneur.2019.00435
Keywords: Zika Virus; GBS; Neurology; Mexico.