[Source: Journal of Antimicrobial Chemotherapy, full page: (LINK). Abstract, edited.]
Detection of the phenicol–oxazolidinone–tetracycline resistance gene poxtA in Enterococcus faecium and Enterococcus faecalis of food-producing animal origin in China
Chang-Wei Lei, Zhuang-Zhuang Kang, Shun-Kang Wu, Yan-Peng Chen, Ling-Han Kong, Hong-Ning Wang
Journal of Antimicrobial Chemotherapy, dkz198, https://doi.org/10.1093/jac/dkz198
Published: 18 May 2019
Issue Section: Research letter
Oxazolidinones, including linezolid and tedizolid, are effective antimicrobial agents for treating infections caused by MDR Gram-positive bacteria, including VRE.1,2Linezolid is the first commercially available oxazolidinone that can inhibit protein synthesis by binding to the peptidyltransferase centre of the bacterial 23S rRNA. After introduction of linezolid, the resistance mechanism that emerged rapidly was related to mutations in genes coding for the 23S rRNA. The transferable oxazolidinone resistance determinants, cfr and optrA, have been reported in enterococci in several regions worldwide.3–6 Very recently, another transferable oxazolidinone resistance gene, poxtA, was reported in an MRSA of clinical origin…
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Keywords: Antibiotics; Drugs Resistance; Linezolid; Enterococcus spp.; Food Safety; China.