Post-exposure administration of a #Yersinia pestis live #vaccine potentiates second-line #antibiotic #treatment against #pneumonic #plague (J Infect Dis., abstract)

[Source: Journal of Infectious Diseases, full page: (LINK). Abstract, edited.]

Post-exposure administration of a Yersinia pestislive vaccine potentiates second-line antibiotic treatment against pneumonic plague

A Zauberman, D Gur, Y Levy, M Aftalion, Y Vagima, A Tidhar, T Chitlaru, E Mamroud

The Journal of Infectious Diseases, jiz260, https://doi.org/10.1093/infdis/jiz260

Published: 16 May 2019

 

Abstract

Pneumonic plague, caused by Yersinia pestis, is a rapidly progressing contagious disease. In the plague mouse model, a single immunization with the EV76 live attenuated Y. pestis strain rapidly induced the expression of hemopexin and haptoglobin in the lung and serum, both of which are important in iron sequestration. Immunization against a concomitant lethal Y. pestis respiratory challenge was correlated with temporary inhibition of disease progression. Combining EV76-immunization and second-line antibiotic treatment, which are individually insufficient, led to a synergistic protective effect that represents a proof of concept for efficient combinational therapy in cases of infection with antibiotic-resistant strains.

Y. pestis, plague, antibiotic therapy, EV76, vaccine, ceftriaxone, infection

Issue Section: Brief Report

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Keywords: Antibiotics; Drugs Resistance; Yersinia pestis; Vaccines.

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Giuseppe Michieli

I am an Italian blogger, active since 2005 with main focus on emerging infectious diseases such as avian influenza, SARS, antibiotics resistance, and many other global Health issues. Other fields of interest are: climate change, global warming, geological and biological sciences. My activity consists mainly in collection and analysis of news, public services updates, confronting sources and making decision about what are the 'signals' of an impending crisis (an outbreak, for example). When a signal is detected, I follow traces during the entire course of an event. I started in 2005 my blog ''A TIME'S MEMORY'', now with more than 40,000 posts and 3 millions of web interactions. Subsequently I added an Italian Language blog, then discontinued because of very low traffic and interest. I contributed for seven years to a public forum (FluTrackers.com) in the midst of the Ebola epidemic in West Africa in 2014, I left the site to continue alone my data tracking job.