[Source: Journal of Infectious Diseases, full page: (LINK). Abstract, edited.]
Post-exposure administration of a Yersinia pestislive vaccine potentiates second-line antibiotic treatment against pneumonic plague
A Zauberman, D Gur, Y Levy, M Aftalion, Y Vagima, A Tidhar, T Chitlaru, E Mamroud
The Journal of Infectious Diseases, jiz260, https://doi.org/10.1093/infdis/jiz260
Published: 16 May 2019
Pneumonic plague, caused by Yersinia pestis, is a rapidly progressing contagious disease. In the plague mouse model, a single immunization with the EV76 live attenuated Y. pestis strain rapidly induced the expression of hemopexin and haptoglobin in the lung and serum, both of which are important in iron sequestration. Immunization against a concomitant lethal Y. pestis respiratory challenge was correlated with temporary inhibition of disease progression. Combining EV76-immunization and second-line antibiotic treatment, which are individually insufficient, led to a synergistic protective effect that represents a proof of concept for efficient combinational therapy in cases of infection with antibiotic-resistant strains.
Y. pestis, plague, antibiotic therapy, EV76, vaccine, ceftriaxone, infection
Issue Section: Brief Report
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Keywords: Antibiotics; Drugs Resistance; Yersinia pestis; Vaccines.